PMID- 28100011
OWN - NLM
STAT- MEDLINE
DCOM- 20180130
LR  - 20181202
IS  - 1365-294X (Electronic)
IS  - 0962-1083 (Linking)
VI  - 26
IP  - 5
DP  - 2017 Mar
TI  - Association mapping of morphological traits in wild and captive zebra finches: 
      reliable within, but not between populations.
PG  - 1285-1305
LID - 10.1111/mec.14009 [doi]
AB  - Identifying causal genetic variants underlying heritable phenotypic variation is 
      a long-standing goal in evolutionary genetics. We previously identified several 
      quantitative trait loci (QTL) for five morphological traits in a captive 
      population of zebra finches (Taeniopygia guttata) by whole-genome linkage 
      mapping. We here follow up on these studies with the aim to narrow down on the 
      quantitative trait variants (QTN) in one wild and three captive populations. 
      First, we performed an association study using 672 single nucleotide 
      polymorphisms (SNPs) within candidate genes located in the previously identified 
      QTL regions in a sample of 939 wild-caught zebra finches. Then, we validated the 
      most promising SNP-phenotype associations (n = 25 SNPs) in 5228 birds from four 
      populations. Genotype-phenotype associations were generally weak in the wild 
      population, where linkage disequilibrium (LD) spans only short genomic distances. 
      In contrast, in captive populations, where LD blocks are large, apparent SNP 
      effects on morphological traits (i.e. associations) were highly repeatable with 
      independent data from the same population. Most of those SNPs also showed 
      significant associations with the same trait in other captive populations, but 
      the direction and magnitude of these effects varied among populations. This 
      suggests that the tested SNPs are not the causal QTN but rather physically linked 
      to them, and that LD between SNPs and causal variants differs between populations 
      due to founder effects. While the identification of QTN remains challenging in 
      nonmodel organisms, we illustrate that it is indeed possible to confirm the 
      location and magnitude of QTL in a population with stable linkage between markers 
      and causal variants.
CI  - (c) 2017 John Wiley & Sons Ltd.
FAU - Knief, Ulrich
AU  - Knief U
AUID- ORCID: 0000-0001-6959-3033
AD  - Department of Behavioural Ecology and Evolutionary Genetics, Max Planck Institute 
      for Ornithology, 82319, Seewiesen, Germany.
FAU - Schielzeth, Holger
AU  - Schielzeth H
AD  - Department of Population Ecology, Friedrich Schiller University Jena, 07743, 
      Jena, Germany.
FAU - Backstrom, Niclas
AU  - Backstrom N
AD  - Department of Ecology and Genetics, Uppsala University, 752 36, Uppsala, Sweden.
FAU - Hemmrich-Stanisak, Georg
AU  - Hemmrich-Stanisak G
AD  - Institute of Clinical Molecular Biology, Christian-Albrechts-University, 24105, 
      Kiel, Germany.
FAU - Wittig, Michael
AU  - Wittig M
AD  - Institute of Clinical Molecular Biology, Christian-Albrechts-University, 24105, 
      Kiel, Germany.
FAU - Franke, Andre
AU  - Franke A
AD  - Institute of Clinical Molecular Biology, Christian-Albrechts-University, 24105, 
      Kiel, Germany.
FAU - Griffith, Simon C
AU  - Griffith SC
AD  - Department of Biological Sciences, Macquarie University, Sydney, NSW, 2109, 
      Australia.
AD  - School of Biological, Earth & Environmental Sciences, University of New South 
      Wales, Sydney, NSW, 2057, Australia.
FAU - Ellegren, Hans
AU  - Ellegren H
AD  - Department of Ecology and Genetics, Uppsala University, 752 36, Uppsala, Sweden.
FAU - Kempenaers, Bart
AU  - Kempenaers B
AD  - Department of Behavioural Ecology and Evolutionary Genetics, Max Planck Institute 
      for Ornithology, 82319, Seewiesen, Germany.
FAU - Forstmeier, Wolfgang
AU  - Forstmeier W
AD  - Department of Behavioural Ecology and Evolutionary Genetics, Max Planck Institute 
      for Ornithology, 82319, Seewiesen, Germany.
LA  - eng
PT  - Journal Article
DEP - 20170206
PL  - England
TA  - Mol Ecol
JT  - Molecular ecology
JID - 9214478
SB  - IM
MH  - Animals
MH  - Chromosome Mapping
MH  - Finches/anatomy & histology/*genetics
MH  - *Genetics, Population
MH  - Genotype
MH  - *Linkage Disequilibrium
MH  - Phenotype
MH  - Polymorphism, Single Nucleotide
MH  - *Quantitative Trait Loci
OTO - NOTNLM
OT  - association study
OT  - genotype-phenotype maps
OT  - linkage mapping
OT  - morphology
OT  - quantitative trait locus
OT  - standing genetic variation
EDAT- 2017/01/19 06:00
MHDA- 2018/01/31 06:00
CRDT- 2017/01/19 06:00
PHST- 2016/04/20 00:00 [received]
PHST- 2016/12/05 00:00 [revised]
PHST- 2016/12/21 00:00 [accepted]
PHST- 2017/01/19 06:00 [pubmed]
PHST- 2018/01/31 06:00 [medline]
PHST- 2017/01/19 06:00 [entrez]
AID - 10.1111/mec.14009 [doi]
PST - ppublish
SO  - Mol Ecol. 2017 Mar;26(5):1285-1305. doi: 10.1111/mec.14009. Epub 2017 Feb 6.