PMID- 28100709
OWN - NLM
STAT- MEDLINE
DCOM- 20180116
LR  - 20220408
IS  - 1532-298X (Electronic)
IS  - 1040-4651 (Print)
IS  - 1040-4651 (Linking)
VI  - 29
IP  - 2
DP  - 2017 Feb
TI  - The Arabidopsis RING-Type E3 Ligase TEAR1 Controls Leaf Development by Targeting 
      the TIE1 Transcriptional Repressor for Degradation.
PG  - 243-259
LID - 10.1105/tpc.16.00771 [doi]
AB  - The developmental plasticity of leaf size and shape is important for leaf 
      function and plant survival. However, the mechanisms by which plants form diverse 
      leaves in response to environmental conditions are not well understood. Here, we 
      identified TIE1-ASSOCIATED RING-TYPE E3 LIGASE1 (TEAR1) and found that it 
      regulates leaf development by promoting the degradation of TCP 
      INTERACTOR-CONTAINING EAR MOTIF PROTEIN1 (TIE1), an important repressor of 
      CINCINNATA (CIN)-like TEOSINTE BRANCHED1/CYCLOIDEA/PCF (TCP) transcription 
      factors, which are key for leaf development. TEAR1 contains a typical C3H2C3-type 
      RING domain and has E3 ligase activity. We show that TEAR1 interacts with the TCP 
      repressor TIE1, which is ubiquitinated in vivo and degraded by the 26S proteasome 
      system. We demonstrate that TEAR1 is colocalized with TIE1 in nuclei and 
      negatively regulates TIE1 protein levels. Overexpression of TEAR1 rescued leaf 
      defects caused by TIE1 overexpression, whereas disruption of TEAR1 resulted in 
      leaf phenotypes resembling those caused by TIE1 overexpression or TCP 
      dysfunction. Deficiency in TEAR partially rescued the leaf defects of TCP4 
      overexpression line and enhanced the wavy leaf phenotypes of jaw-5D We propose 
      that TEAR1 positively regulates CIN-like TCP activity to promote leaf development 
      by mediating the degradation of the TCP repressor TIE1.
CI  - (c) 2017 American Society of Plant Biologists. All rights reserved.
FAU - Zhang, Jinzhe
AU  - Zhang J
AD  - State Key Laboratory of Protein and Plant Gene Research, College of Life 
      Sciences, Peking University, Beijing 100871, People's Republic of China.
FAU - Wei, Baoye
AU  - Wei B
AD  - State Key Laboratory of Protein and Plant Gene Research, College of Life 
      Sciences, Peking University, Beijing 100871, People's Republic of China.
FAU - Yuan, Rongrong
AU  - Yuan R
AD  - State Key Laboratory of Protein and Plant Gene Research, College of Life 
      Sciences, Peking University, Beijing 100871, People's Republic of China.
FAU - Wang, Jianhui
AU  - Wang J
AUID- ORCID: 0000-0003-1532-0448
AD  - State Key Laboratory of Protein and Plant Gene Research, College of Life 
      Sciences, Peking University, Beijing 100871, People's Republic of China.
FAU - Ding, Mingxin
AU  - Ding M
AUID- ORCID: 0000-0002-4296-5033
AD  - State Key Laboratory of Protein and Plant Gene Research, College of Life 
      Sciences, Peking University, Beijing 100871, People's Republic of China.
FAU - Chen, Zhuoyao
AU  - Chen Z
AUID- ORCID: 0000-0003-4201-4649
AD  - State Key Laboratory of Protein and Plant Gene Research, College of Life 
      Sciences, Peking University, Beijing 100871, People's Republic of China.
FAU - Yu, Hao
AU  - Yu H
AD  - State Key Laboratory of Protein and Plant Gene Research, College of Life 
      Sciences, Peking University, Beijing 100871, People's Republic of China.
FAU - Qin, Genji
AU  - Qin G
AUID- ORCID: 0000-0002-6995-5126
AD  - State Key Laboratory of Protein and Plant Gene Research, College of Life 
      Sciences, Peking University, Beijing 100871, People's Republic of China 
      qingenji@pku.edu.cn.
AD  - School of Advanced Agricultural Sciences, Peking University, Beijing 100871, 
      People's Republic of China.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20170118
PL  - England
TA  - Plant Cell
JT  - The Plant cell
JID - 9208688
RN  - 0 (Arabidopsis Proteins)
RN  - 0 (Repressor Proteins)
RN  - 0 (TIE1 protein, Arabidopsis)
RN  - EC 2.3.2.27 (TEAR1 protein, Arabidopsis)
RN  - EC 2.3.2.27 (Ubiquitin-Protein Ligases)
SB  - IM
MH  - Arabidopsis/genetics/*growth & development/metabolism
MH  - Arabidopsis Proteins/genetics/metabolism/*physiology
MH  - Cloning, Molecular
MH  - Gene Expression Regulation, Plant
MH  - Meristem/metabolism
MH  - Models, Genetic
MH  - Plant Leaves/genetics/growth & development/metabolism
MH  - Repressor Proteins/*genetics/metabolism
MH  - Ubiquitin-Protein Ligases/genetics/metabolism/*physiology
PMC - PMC5354194
EDAT- 2017/01/20 06:00
MHDA- 2018/01/18 06:00
PMCR- 2017/01/18
CRDT- 2017/01/20 06:00
PHST- 2016/10/04 00:00 [received]
PHST- 2017/01/03 00:00 [revised]
PHST- 2017/01/17 00:00 [accepted]
PHST- 2017/01/20 06:00 [pubmed]
PHST- 2018/01/18 06:00 [medline]
PHST- 2017/01/20 06:00 [entrez]
PHST- 2017/01/18 00:00 [pmc-release]
AID - tpc.16.00771 [pii]
AID - TPC201600771RAR2 [pii]
AID - 10.1105/tpc.16.00771 [doi]
PST - ppublish
SO  - Plant Cell. 2017 Feb;29(2):243-259. doi: 10.1105/tpc.16.00771. Epub 2017 Jan 18.