PMID- 28100903
OWN - NLM
STAT- MEDLINE
DCOM- 20170309
LR  - 20190609
IS  - 1941-5923 (Electronic)
IS  - 1941-5923 (Linking)
VI  - 18
DP  - 2017 Jan 19
TI  - Rhodoccocus Equi Pneumonia and Paradoxical Immune Reconstitution Inflammatory 
      Syndrome in a Patient with Acquired Immune Deficiency Syndrome (AIDS).
PG  - 67-71
AB  - BACKGROUND Pulmonary infections are a major cause of mortality and morbidity in 
      patients infected with human immunodeficiency virus (HIV) and can progress 
      rapidly to respiratory failure and death without appropriate therapy. Herein, we 
      present a rare case of an advanced HIV infection and Rhodoccocus equi (R. equi) 
      pneumonia in a young male who had severe paradoxical immune reconstitution 
      inflammatory syndrome (IRIS). CASE REPORT A 47-year-old nonsmoking Hispanic man 
      with advanced HIV infection presented with severe acute necrotizing pneumonia 
      secondary to R. equi. Although his initial response to antimicrobial therapy was 
      optimal, he became symptomatic again in spite of continuation of antibiotics as 
      he developed severe paradoxical IRIS 3 weeks after starting a new highly active 
      anti-retroviral therapy (HAART). CONCLUSIONS The diagnosis of IRIS remains 
      challenging because of the wide variations in the clinical presentation and 
      etiologies. In spite of its rarity as an opportunistic pathogen, we recommend 
      that R. equi, an intracellular pathogen, be included in the differential list of 
      pathogens associated with IRIS.
FAU - Zijoo, Ritika
AU  - Zijoo R
AD  - Department of Internal Medicine, Saint Francis Medical Center, Seton Hall 
      University, Trenton, NJ, USA.
FAU - Dirweesh, Ahmed
AU  - Dirweesh A
AD  - Department of Internal Medicine, Saint Francis Medical Center, Seton Hall 
      University, Trenton, NJ, USA.
FAU - Karabulut, Nigahus
AU  - Karabulut N
AD  - Department of Infectious Diseases, Saint Francis Medical Center, Trenton, NJ, 
      USA.
LA  - eng
PT  - Case Reports
PT  - Journal Article
DEP - 20170119
PL  - United States
TA  - Am J Case Rep
JT  - The American journal of case reports
JID - 101489566
SB  - IM
MH  - Acquired Immunodeficiency Syndrome/*complications
MH  - Biopsy
MH  - *HIV
MH  - Humans
MH  - Immune Reconstitution Inflammatory Syndrome/diagnosis/*etiology
MH  - Male
MH  - Middle Aged
MH  - Pneumonia/diagnosis/*etiology
MH  - Tomography, X-Ray Computed
PMC - PMC5267618
COIS- Conflicts of Interest: None declared Conflicts of interest None.
EDAT- 2017/01/20 06:00
MHDA- 2017/03/10 06:00
PMCR- 2017/01/19
CRDT- 2017/01/20 06:00
PHST- 2017/01/20 06:00 [entrez]
PHST- 2017/01/20 06:00 [pubmed]
PHST- 2017/03/10 06:00 [medline]
PHST- 2017/01/19 00:00 [pmc-release]
AID - 900901 [pii]
AID - 10.12659/ajcr.900901 [doi]
PST - epublish
SO  - Am J Case Rep. 2017 Jan 19;18:67-71. doi: 10.12659/ajcr.900901.