PMID- 28101318
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20201001
IS  - 2045-1253 (Print)
IS  - 2045-1261 (Electronic)
IS  - 2045-1253 (Linking)
VI  - 7
IP  - 1
DP  - 2017 Jan
TI  - Prevalence and correlates of antipsychotic polypharmacy among outpatients with 
      schizophrenia attending a tertiary psychiatric facility in Nigeria.
PG  - 3-10
LID - 10.1177/2045125316672134 [doi]
AB  - BACKGROUND: The study aimed to determine the prevalence, pattern and correlates 
      of antipsychotic polypharmacy (APP) among outpatients with schizophrenia 
      attending a tertiary psychiatric facility in Nigeria. METHOD: A cross-sectional 
      study of 250 patients with schizophrenia attending the outpatient clinic of a 
      regional tertiary psychiatric facility in Nigeria was undertaken. They were 
      administered a sociodemographic questionnaire, the Positive and Negative Syndrome 
      Scale (PANSS), the Global Assessment of Functioning (GAF) scale and the Liverpool 
      University Side Effects Rating Scale (LUNSERS). RESULTS: Of the 250 subjects 
      interviewed, 176 (70.4%) were on APP. APP was significantly associated with 
      higher prescribed chlorpromazine equivalent doses of antipsychotics (p < 0.001), 
      increased frequency of dosing (p < 0.001), negative symptoms (p < 0.01), poorer 
      functioning (p = 0.04) and greater side-effect burden (p = 0.04). CONCLUSION: The 
      APP rate reported from this study is high. Clinicians should be mindful of its 
      impact on dosage and side-effect profiles as APP use is associated with negative 
      symptoms and poor psychosocial functioning.
FAU - Igbinomwanhia, Nosa Godwin
AU  - Igbinomwanhia NG
AD  - Department of Clinical Services, Federal Neuro-Psychiatric Hospital, P.M.B 1108, 
      Benin City, Nigeria.
FAU - Olotu, Sunday Osasu
AU  - Olotu SO
AD  - Department of Clinical Services, Federal Neuro-Psychiatric Hospital, Benin City, 
      Nigeria.
FAU - James, Bawo Onesirosan
AU  - James BO
AD  - Department of Clinical Services, Federal Neuro-Psychiatric Hospital, Benin City, 
      Nigeria.
LA  - eng
PT  - Journal Article
DEP - 20161013
PL  - England
TA  - Ther Adv Psychopharmacol
JT  - Therapeutic advances in psychopharmacology
JID - 101555693
PMC - PMC5228713
OTO - NOTNLM
OT  - Nigeria
OT  - antipsychotic
OT  - correlates
OT  - polypharmacy
OT  - prevalence
OT  - schizophrenia
COIS- The authors declare that there is no conflict of interest.
EDAT- 2017/01/20 06:00
MHDA- 2017/01/20 06:01
PMCR- 2017/01/01
CRDT- 2017/01/20 06:00
PHST- 2017/01/20 06:00 [entrez]
PHST- 2017/01/20 06:00 [pubmed]
PHST- 2017/01/20 06:01 [medline]
PHST- 2017/01/01 00:00 [pmc-release]
AID - 10.1177_2045125316672134 [pii]
AID - 10.1177/2045125316672134 [doi]
PST - ppublish
SO  - Ther Adv Psychopharmacol. 2017 Jan;7(1):3-10. doi: 10.1177/2045125316672134. Epub 
      2016 Oct 13.