PMID- 28101856 OWN - NLM STAT- MEDLINE DCOM- 20170814 LR - 20181113 IS - 2190-3883 (Electronic) IS - 1234-1983 (Linking) VI - 58 IP - 3 DP - 2017 Aug TI - Relationship of long-term prognosis to MMP and TIMP polymorphisms in patients after ST elevation myocardial infarction. PG - 331-341 LID - 10.1007/s13353-016-0388-8 [doi] AB - The influence of polymorphisms in the large group of MMP and TIMP genes on clinical outcomes in patients after ST elevation myocardial infarction (STEMI) treated with primary PCI was analysed. In total, 550 consecutive Caucasian patients with STEMI were included in the present study, with a median of 32 months. We analysed 19 polymorphisms in the genes coding MMP and TIMP genes. The MMP-1 -519A/G and -422A/T polymorphisms are associated with combined endpoint after myocardial infarction. The hazard ratio for AT variant of MMP-1 -422A/T was 1.75 (p < 0.001); the variants with at least one A allele of MMP-1 -519A/G have less risk of combined endpoint. The TT variants of -1562C/T MMP-9 and at least one T allele of +92C/T MMP-13 were considered in a trend to affect disease progression and long-term survival after myocardial infarction. According to reclassification analysis NRI and IDI, long-term risk stratification using MMP-1 -422A/T and -519A/G polymorphisms gives additional information to the commonly used GRACE risk score. Patient stratification after myocardial infraction (MI) according to risk genotypes of MMP-1 polymorphisms could have important clinical implications for identification of patients at risk and therapeutic strategies. FAU - Pavkova Goldbergova, Monika AU - Pavkova Goldbergova M AD - Faculty of Medicine, Masaryk University, Brno, Czech Republic. FAU - Jarkovsky, Jiri AU - Jarkovsky J AD - Institute of Biostatistics and Analyses, Masaryk University, Brno, Czech Republic. FAU - Lipkova, Jolana AU - Lipkova J AD - Faculty of Medicine, Masaryk University, Brno, Czech Republic. FAU - Littnerova, Simona AU - Littnerova S AD - Institute of Biostatistics and Analyses, Masaryk University, Brno, Czech Republic. FAU - Poloczek, Martin AU - Poloczek M AD - Faculty of Medicine, Masaryk University, Brno, Czech Republic. AD - Cardiology Department, Faculty Hospital Brno, Brno, Czech Republic. FAU - Spinar, Jindrich AU - Spinar J AD - Faculty of Medicine, Masaryk University, Brno, Czech Republic. AD - Cardiology Department, Faculty Hospital Brno, Brno, Czech Republic. AD - International Clinical Research Center - Department of Cardiovascular Disease, University Hospital St. Annes's, Brno, Czech Republic. FAU - Kubkova, Lenka AU - Kubkova L AD - Faculty of Medicine, Masaryk University, Brno, Czech Republic. AD - Cardiology Department, Faculty Hospital Brno, Brno, Czech Republic. AD - International Clinical Research Center - Department of Cardiovascular Disease, University Hospital St. Annes's, Brno, Czech Republic. FAU - Kluz, Krystyna AU - Kluz K AD - Faculty of Medicine, Masaryk University, Brno, Czech Republic. AD - Hospital Podlesi a.s., Trinec, Czech Republic. FAU - Kala, Petr AU - Kala P AD - Faculty of Medicine, Masaryk University, Brno, Czech Republic. AD - Cardiology Department, Faculty Hospital Brno, Brno, Czech Republic. FAU - Manousek, Jan AU - Manousek J AD - Faculty of Medicine, Masaryk University, Brno, Czech Republic. AD - Cardiology Department, Faculty Hospital Brno, Brno, Czech Republic. FAU - Vasku, Anna AU - Vasku A AD - Faculty of Medicine, Masaryk University, Brno, Czech Republic. FAU - Parenica, Jiri AU - Parenica J AD - Faculty of Medicine, Masaryk University, Brno, Czech Republic. jiri.parenica@atlas.cz. AD - Cardiology Department, Faculty Hospital Brno, Brno, Czech Republic. jiri.parenica@atlas.cz. AD - International Clinical Research Center - Department of Cardiovascular Disease, University Hospital St. Annes's, Brno, Czech Republic. jiri.parenica@atlas.cz. AD - Cardiology Department, University Hospital Brno, Jihlavska 20, Brno, 625 00, Czech Republic. jiri.parenica@atlas.cz. LA - eng PT - Journal Article DEP - 20170118 PL - England TA - J Appl Genet JT - Journal of applied genetics JID - 9514582 RN - 0 (Tissue Inhibitor of Metalloproteinases) RN - EC 3.4.24.- (MMP13 protein, human) RN - EC 3.4.24.- (Matrix Metalloproteinase 13) RN - EC 3.4.24.35 (MMP9 protein, human) RN - EC 3.4.24.35 (Matrix Metalloproteinase 9) RN - EC 3.4.24.7 (MMP1 protein, human) RN - EC 3.4.24.7 (Matrix Metalloproteinase 1) SB - IM MH - Adult MH - Aged MH - Alleles MH - Female MH - Humans MH - Male MH - Matrix Metalloproteinase 1/*genetics MH - Matrix Metalloproteinase 13/genetics MH - Matrix Metalloproteinase 9/genetics MH - Middle Aged MH - Percutaneous Coronary Intervention MH - Polymorphism, Genetic MH - Prognosis MH - Risk Factors MH - ST Elevation Myocardial Infarction/diagnosis/*genetics MH - Tissue Inhibitor of Metalloproteinases/*genetics OTO - NOTNLM OT - MMP OT - Polymorphism OT - Prognosis OT - STEMI OT - TIMP EDAT- 2017/01/20 06:00 MHDA- 2017/08/15 06:00 CRDT- 2017/01/20 06:00 PHST- 2015/10/21 00:00 [received] PHST- 2016/12/20 00:00 [accepted] PHST- 2016/12/15 00:00 [revised] PHST- 2017/01/20 06:00 [pubmed] PHST- 2017/08/15 06:00 [medline] PHST- 2017/01/20 06:00 [entrez] AID - 10.1007/s13353-016-0388-8 [pii] AID - 10.1007/s13353-016-0388-8 [doi] PST - ppublish SO - J Appl Genet. 2017 Aug;58(3):331-341. doi: 10.1007/s13353-016-0388-8. Epub 2017 Jan 18.