PMID- 28102034 OWN - NLM STAT- MEDLINE DCOM- 20180607 LR - 20221207 IS - 2059-2310 (Electronic) IS - 2059-2302 (Linking) VI - 89 IP - 2 DP - 2017 Feb TI - Common and well-documented HLA alleles over all of Europe and within European sub-regions: A catalogue from the European Federation for Immunogenetics. PG - 104-113 LID - 10.1111/tan.12956 [doi] AB - BACKGROUND: A catalogue of common and well-documented (CWD) human leukocyte antigen (HLA), previously established by the American Society for Histocompatibility and Immunogenetics (ASHI), is widely used as indicator for typing ambiguities to be resolved in tissue transplantation or for checking the universality of any HLA allele in the world. However, European population samples, which are characterized by a substantial level of genetic variation, are underrepresented in the ASHI catalogue. Therefore, the Population Genetics Working Group of the European Federation for Immunogenetics (EFI) has facilitated data collection for an European CWD catalogue. MATERIALS AND METHODS: To this end, 2nd-field HLA-A, -B, -C,- DRB1,- DQA1,- DQB1 and -DPB1 data of 77 to 121 European population samples (21 571-3 966 984 individuals) from 3 large databases, HLA-net/Gene[VA], allelefrequencies.net and DKMS, were analysed. RESULTS: The total number of CWD alleles is similar in the EFI (N = 1048) and ASHI (N = 1031) catalogues, but the former counts less common (N = 236 vs 377) and more well-documented (N = 812 vs 654) alleles than the latter, possibly reflecting differences in sample numbers and sizes. Interestingly, approximately half of the CWD alleles reported by EFI were not reported by ASHI and vice-versa, underlining the distinct features of the two catalogues. Also, although 78 common alleles are widely distributed across Europe, some alleles are only common within specific sub-regions, showing regional variability. CONCLUSION: Although the definition of CWD alleles itself is affected by different parameters, calling for current updates of the list, the EFI CWD catalogue provides new insights into European population genetics and will be a very useful tool for tissue-typing laboratories in and beyond Europe. CI - (c) 2017 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd. FAU - Sanchez-Mazas, A AU - Sanchez-Mazas A AD - Laboratory of Anthropology, Genetics and Peopling history (AGP), Department of Genetics and Evolution-Anthropology Unit, University of Geneva, Geneva, Switzerland. AD - Institute of Genetics and Genomics in Geneva (IGE3), University of Geneva Medical Center (CMU), Geneva, Switzerland. AD - Population Genetics Working Group of the European Federation for Immunogenetics (EFI), EFI Central Office, Leiden, The Netherlands. FAU - Nunes, J M AU - Nunes JM AD - Laboratory of Anthropology, Genetics and Peopling history (AGP), Department of Genetics and Evolution-Anthropology Unit, University of Geneva, Geneva, Switzerland. AD - Institute of Genetics and Genomics in Geneva (IGE3), University of Geneva Medical Center (CMU), Geneva, Switzerland. AD - Population Genetics Working Group of the European Federation for Immunogenetics (EFI), EFI Central Office, Leiden, The Netherlands. FAU - Middleton, D AU - Middleton D AD - Population Genetics Working Group of the European Federation for Immunogenetics (EFI), EFI Central Office, Leiden, The Netherlands. AD - Transplant Immunology Laboratory, Royal Liverpool and Broadgreen University Hospital, Liverpool, UK. FAU - Sauter, J AU - Sauter J AD - DKMS, German Bone Marrow Center, Tubingen, Germany. FAU - Buhler, S AU - Buhler S AUID- ORCID: 0000-0001-6675-5287 AD - Laboratory of Anthropology, Genetics and Peopling history (AGP), Department of Genetics and Evolution-Anthropology Unit, University of Geneva, Geneva, Switzerland. AD - Transplantation Immunology Unit and National Reference Laboratory for Histocompatibility (UIT/LNRH), Department of Genetic and Laboratory Medicine, Geneva University Hospitals, Geneva, Switzerland. FAU - McCabe, A AU - McCabe A AD - Institute of Integrative Biology, University of Liverpool, Liverpool, UK. FAU - Hofmann, J AU - Hofmann J AD - DKMS, German Bone Marrow Center, Tubingen, Germany. FAU - Baier, D M AU - Baier DM AD - DKMS, German Bone Marrow Center, Tubingen, Germany. FAU - Schmidt, A H AU - Schmidt AH AD - DKMS, German Bone Marrow Center, Tubingen, Germany. FAU - Nicoloso, G AU - Nicoloso G AD - Swiss Transfusion Swiss Red Cross (SRC)/Swiss Blood Stem Cells, Bern, Switzerland. FAU - Andreani, M AU - Andreani M AUID- ORCID: 0000-0003-3451-3624 AD - Population Genetics Working Group of the European Federation for Immunogenetics (EFI), EFI Central Office, Leiden, The Netherlands. AD - Laboratory of Immunogenetics and Transplant Biology, IME Foundation, Policlinic of the University of Tor Vergata, Rome, Italy. FAU - Grubic, Z AU - Grubic Z AD - Population Genetics Working Group of the European Federation for Immunogenetics (EFI), EFI Central Office, Leiden, The Netherlands. AD - Tissue Typing Center, University Hospital Center Zagreb, Zagreb, Croatia. FAU - Tiercy, J-M AU - Tiercy JM AD - Population Genetics Working Group of the European Federation for Immunogenetics (EFI), EFI Central Office, Leiden, The Netherlands. AD - Transplantation Immunology Unit and National Reference Laboratory for Histocompatibility (UIT/LNRH), Department of Genetic and Laboratory Medicine, Geneva University Hospitals, Geneva, Switzerland. FAU - Fleischhauer, K AU - Fleischhauer K AD - Population Genetics Working Group of the European Federation for Immunogenetics (EFI), EFI Central Office, Leiden, The Netherlands. AD - Institute for Experimental Cellular Therapy, University Hospital Essen, Essen, Germany. AD - German Cancer Consortium (DKTK), German Cancer Research Center, Heidelberg, Germany. LA - eng PT - Journal Article PL - England TA - HLA JT - HLA JID - 101675570 RN - 0 (HLA Antigens) SB - IM MH - *Alleles MH - Databases, Factual MH - Europe MH - Gene Expression MH - Gene Frequency MH - *Genetic Variation MH - Genetics, Population MH - HLA Antigens/classification/*genetics/immunology MH - *Haplotypes MH - Histocompatibility Testing MH - Humans MH - Immunogenetics/*methods MH - Terminology as Topic MH - White People OTO - NOTNLM OT - CWD catalogue OT - EFI OT - Europe OT - HLA alleles OT - population genetics OT - tissue typing EDAT- 2017/01/20 06:00 MHDA- 2018/06/08 06:00 CRDT- 2017/01/20 06:00 PHST- 2016/10/25 00:00 [received] PHST- 2016/11/30 00:00 [revised] PHST- 2016/12/19 00:00 [accepted] PHST- 2017/01/20 06:00 [entrez] PHST- 2017/01/20 06:00 [pubmed] PHST- 2018/06/08 06:00 [medline] AID - 10.1111/tan.12956 [doi] PST - ppublish SO - HLA. 2017 Feb;89(2):104-113. doi: 10.1111/tan.12956.