PMID- 28102039
OWN - NLM
STAT- MEDLINE
DCOM- 20180607
LR  - 20180821
IS  - 2059-2310 (Electronic)
IS  - 2059-2302 (Linking)
VI  - 89
IP  - 2
DP  - 2017 Feb
TI  - A dispermic chimerism detected in a Taiwanese potential unrelated hematopoietic 
      stem cell donor.
PG  - 98-103
LID - 10.1111/tan.12954 [doi]
AB  - Chimerism is defined as the presence of 2 or more than 1 genetically distinct 
      cell populations in an organism. Dispermic chimeras are derived from the 
      fertilization of 1 or 2 matured nuclei by 2 sperms. We here report detection of a 
      healthy and phenotypically normal female with normal ABO red blood cell typing in 
      whom dispermic chimerism was suspected after 3 alleles were identified at 
      multiple human leukocyte antigen (HLA) loci using molecular HLA analysis. 
      Molecular HLA typing showed the donor to have 3 HLA-A, -B, -C, -DRB1, -DQB1 and 
      -DPB1 alleles in blood, saliva and nail samples. In addition, 3 of her 9 short 
      tandem repeat loci also showed to have 3 distinct alleles in blood, nail and 
      saliva specimens. In all investigations, the third alleles were attributed to a 
      dual paternal contribution. This case represents a dispermic chimerism, with 2 
      paternal and 1 maternal haplotypes variably distributed throughout body tissues 
      in a healthy and phenotypically normal female without abnormalities in 
      erythrocyte ABO blood group. The origin of this chimerism is probably due to the 
      fertilization of a single egg and its polar body, or a parthenogenetic egg, by 2 
      sperms.
CI  - (c) 2017 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.
FAU - Yang, E K L
AU  - Yang EK
AUID- ORCID: 0000-0001-7440-2318
AD  - Laboratory of Immunogenetics, Tzu Chi Cord Blood Bank, and Buddhist Tzu Chi Bone 
      Marrow Donor Registry, Buddhist Tzu Chi Stem Cells Centre, Hualien Tzu Chi 
      Hospital, Hualien, Taiwan.
AD  - Department of Laboratory Medicine, Buddhist Tzu Chi University, Hualien, Taiwan.
FAU - Marsh, S G E
AU  - Marsh SG
AUID- ORCID: 0000-0003-2855-4120
AD  - Anthony Nolan Research Institute and UCL Cancer Institute, The Royal Free Campus, 
      London, UK.
FAU - Chen, P-Y
AU  - Chen PY
AD  - Center of Medical Genetics, Hualien Tzu Chi Hospital, Hualien, Taiwan.
FAU - Chen, C-P
AU  - Chen CP
AD  - Department of Obstetrics and Gynecology, Mackay Memorial Hospital, Taipei, 
      Taiwan.
FAU - Chen, S-P
AU  - Chen SP
AD  - Laboratory of Immunogenetics, Tzu Chi Cord Blood Bank, and Buddhist Tzu Chi Bone 
      Marrow Donor Registry, Buddhist Tzu Chi Stem Cells Centre, Hualien Tzu Chi 
      Hospital, Hualien, Taiwan.
FAU - Lin, P Y
AU  - Lin PY
AD  - Laboratory of Immunogenetics, Tzu Chi Cord Blood Bank, and Buddhist Tzu Chi Bone 
      Marrow Donor Registry, Buddhist Tzu Chi Stem Cells Centre, Hualien Tzu Chi 
      Hospital, Hualien, Taiwan.
LA  - eng
PT  - Case Reports
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - HLA
JT  - HLA
JID - 101675570
RN  - 0 (ABO Blood-Group System)
RN  - 0 (HLA-A Antigens)
RN  - 0 (HLA-B Antigens)
RN  - 0 (HLA-C Antigens)
RN  - 0 (HLA-DP beta-Chains)
RN  - 0 (HLA-DPB1 antigen)
RN  - 0 (HLA-DQ beta-Chains)
RN  - 0 (HLA-DQB1 antigen)
RN  - 0 (HLA-DRB1 Chains)
SB  - IM
MH  - ABO Blood-Group System/blood/genetics/immunology
MH  - Adult
MH  - *Alleles
MH  - *Chimerism
MH  - Female
MH  - Gene Expression
MH  - *Genotype
MH  - HLA-A Antigens/blood/genetics/immunology
MH  - HLA-B Antigens/blood/genetics/immunology
MH  - HLA-C Antigens/blood/genetics/immunology
MH  - HLA-DP beta-Chains/blood/genetics/immunology
MH  - HLA-DQ beta-Chains/blood/genetics/immunology
MH  - HLA-DRB1 Chains/blood/genetics/immunology
MH  - Healthy Volunteers
MH  - Hematopoietic Stem Cell Transplantation
MH  - Humans
MH  - *Inheritance Patterns
MH  - Microsatellite Repeats
MH  - Nails/chemistry
MH  - Pedigree
MH  - Saliva/chemistry
MH  - Taiwan
MH  - *Unrelated Donors
OTO - NOTNLM
OT  - chimerism
OT  - hematopoietic stem cell donors
OT  - human leukocyte antigen
OT  - sequence-based typing
OT  - short tandem repeat
EDAT- 2017/01/20 06:00
MHDA- 2018/06/08 06:00
CRDT- 2017/01/20 06:00
PHST- 2016/07/05 00:00 [received]
PHST- 2016/11/08 00:00 [revised]
PHST- 2016/12/09 00:00 [accepted]
PHST- 2017/01/20 06:00 [entrez]
PHST- 2017/01/20 06:00 [pubmed]
PHST- 2018/06/08 06:00 [medline]
AID - 10.1111/tan.12954 [doi]
PST - ppublish
SO  - HLA. 2017 Feb;89(2):98-103. doi: 10.1111/tan.12954.