PMID- 28102042
OWN - NLM
STAT- MEDLINE
DCOM- 20180607
LR  - 20211204
IS  - 2059-2310 (Electronic)
IS  - 2059-2302 (Linking)
VI  - 89
IP  - 2
DP  - 2017 Feb
TI  - Identification of a 10/10 matched donor for patients with an uncommon haplotype 
      is unlikely.
PG  - 77-81
LID - 10.1111/tan.12946 [doi]
AB  - BACKGROUND: Despite over 6 million subjects contributing to the National Marrow 
      Donor Program human leukocyte antigen (HLA) haplotype frequency reference data 
      (HFD), haplotypes cannot be predicted from the HLA assignments of some patients 
      searching for an unrelated donor (URD) in the Be The Match Registry(R). We aimed to 
      determine the incidence of these patient searches and whether haplotypes lacking 
      from the HFD can be found among the low-resolution typed URD pool. MATERIALS AND 
      METHODS: New NMDP searches with uncommon patient haplotypes (UPH), defined as a 
      lack of haplotype pairs in any single ethnic group in the HFD based upon 
      HLA-A C B DRB1 DQB1, were identified. Each search had up to 20 potential 10/10 or 
      8/8 URDs typed to determine the likelihood of an allele match. RESULTS: The 
      incidence of patient searches without haplotype pairs in a single ethnic group in 
      the HFD was 1.2% (N=144 out of 12,172) and a majority of these patients (117; 
      81%) had one uncommon haplotype previously uncharacterized in the HFD. Non-White 
      patients had the highest incidence of UPH. Importantly, no patients with UPH had 
      a 10/10 URD identified. The transplant rate among UPH patients was 15%, and a 
      majority of these patients utilized cord blood units as their transplant stem 
      cell source. CONCLUSION: Therefore, the HLA HFD that informs the HapLogic 
      matching algorithm is thorough as UPH patient searches were infrequent. Since 
      such patients are highly unlikely to have a fully 10/10 matched URD identified, 
      this study supports the identification of alternative stem cell sources including 
      cord blood or a mismatched URD early in the search process.
CI  - (c) 2017 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.
FAU - Olson, J A
AU  - Olson JA
AD  - Immunogenetic Operations and Research, National Marrow Donor Program, 
      Minneapolis, Minnesota.
FAU - Gibbens, Y
AU  - Gibbens Y
AD  - Immunogenetic Operations and Research, National Marrow Donor Program, 
      Minneapolis, Minnesota.
FAU - Tram, K
AU  - Tram K
AD  - Immunogenetic Operations and Research, National Marrow Donor Program, 
      Minneapolis, Minnesota.
FAU - Kempenich, J
AU  - Kempenich J
AD  - Immunogenetic Operations and Research, National Marrow Donor Program, 
      Minneapolis, Minnesota.
FAU - Novakovich, J
AU  - Novakovich J
AD  - Immunogenetic Operations and Research, National Marrow Donor Program, 
      Minneapolis, Minnesota.
FAU - Buck, K
AU  - Buck K
AD  - Immunogenetic Operations and Research, National Marrow Donor Program, 
      Minneapolis, Minnesota.
FAU - Dehn, J
AU  - Dehn J
AD  - Immunogenetic Operations and Research, National Marrow Donor Program, 
      Minneapolis, Minnesota.
LA  - eng
PT  - Journal Article
PL  - England
TA  - HLA
JT  - HLA
JID - 101675570
RN  - 0 (HLA Antigens)
SB  - IM
MH  - *Algorithms
MH  - Alleles
MH  - Bone Marrow Transplantation/*methods
MH  - Cord Blood Stem Cell Transplantation/ethnology/*methods
MH  - Gene Expression
MH  - Gene Frequency
MH  - HLA Antigens/classification/*genetics/immunology
MH  - Haplotypes
MH  - Hematopoietic Stem Cell Transplantation/ethnology/*methods
MH  - Histocompatibility Testing
MH  - Humans
MH  - Probability
MH  - Racial Groups
MH  - *Registries
MH  - United States
MH  - Unrelated Donors/statistics & numerical data/supply & distribution
OTO - NOTNLM
OT  - HLA typing
OT  - haplotype
OT  - uncommon HLA
OT  - unrelated donor
EDAT- 2017/01/20 06:00
MHDA- 2018/06/08 06:00
CRDT- 2017/01/20 06:00
PHST- 2016/07/26 00:00 [received]
PHST- 2016/11/28 00:00 [revised]
PHST- 2016/11/29 00:00 [accepted]
PHST- 2017/01/20 06:00 [entrez]
PHST- 2017/01/20 06:00 [pubmed]
PHST- 2018/06/08 06:00 [medline]
AID - 10.1111/tan.12946 [doi]
PST - ppublish
SO  - HLA. 2017 Feb;89(2):77-81. doi: 10.1111/tan.12946.