PMID- 28104935
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20201001
IS  - 0971-3026 (Print)
IS  - 1998-3808 (Electronic)
IS  - 0970-2016 (Linking)
VI  - 26
IP  - 4
DP  - 2016 Oct-Dec
TI  - Neurotuberculosis immune reconstitution inflammatory syndrome in the setting of 
      HIV infection: A case report and review of literature.
PG  - 446-450
LID - 10.4103/0971-3026.195782 [doi]
AB  - Immune reconstitution inflammatory syndrome (IRIS) is an exaggerated immune 
      response which can occur with various coinfections in human immunodeficiency 
      virus (HIV) infected patients, of which the most commonly implicated in central 
      nervous system (CNS)-IRIS are progressive multifocal leukoencephalopathy (PML), 
      cryptococcosis, and tuberculosis (TB). TB-IRIS is a known complication of 
      pulmonary TB or TB lymphadenitis coinfection in HIV infected patients who are on 
      antituberculosis treatment (ATT) after the initiation of antiretroviral therapy 
      (ART). However, development of IRIS in extrapulmonary TB such as CNS TB is very 
      rare. Our case is that of an isolated CNS-TB-IRIS, presenting as increase in the 
      size and perilesional edema of the ring enhancing lesions in the brain, which was 
      observed in two sequential magnetic resonance imaging done over a period of 2 
      months in a retropositive patient who presented with clinical deterioration after 
      commencement of ART. As prompt diagnosis was made and specific management aimed 
      at IRIS was started without delay, the patient improved symptomatically.
FAU - Jaganmohan, Deepasree
AU  - Jaganmohan D
AD  - Department of Radiodiagnosis, Jawaharlal Institute of Postgraduate Medical 
      Education and Research (JIPMER), Pondicherry, India.
FAU - Chakkalakkoombil, Sunitha V
AU  - Chakkalakkoombil SV
AD  - Department of Radiodiagnosis, Jawaharlal Institute of Postgraduate Medical 
      Education and Research (JIPMER), Pondicherry, India.
FAU - Beena, Anjana A
AU  - Beena AA
AD  - Department of Medicine, Jawaharlal Institute of Postgraduate Medical Education 
      and Research (JIPMER), Pondicherry, India.
FAU - Krishnan, Nagarajan
AU  - Krishnan N
AD  - Department of Radiodiagnosis, Jawaharlal Institute of Postgraduate Medical 
      Education and Research (JIPMER), Pondicherry, India.
LA  - eng
PT  - Journal Article
PL  - Germany
TA  - Indian J Radiol Imaging
JT  - The Indian journal of radiology & imaging
JID - 8503873
PMC - PMC5201071
OTO - NOTNLM
OT  - Anti-retroviral therapy
OT  - Anti-tubercular treatment
OT  - CNS-TB-IRIS
OT  - human immunodeficiency virus
OT  - immune reconstitution inflammatory syndrome
COIS- There are no conflicts of interest.
EDAT- 2017/01/21 06:00
MHDA- 2017/01/21 06:01
PMCR- 2016/10/01
CRDT- 2017/01/21 06:00
PHST- 2017/01/21 06:00 [entrez]
PHST- 2017/01/21 06:00 [pubmed]
PHST- 2017/01/21 06:01 [medline]
PHST- 2016/10/01 00:00 [pmc-release]
AID - IJRI-26-446 [pii]
AID - 10.4103/0971-3026.195782 [doi]
PST - ppublish
SO  - Indian J Radiol Imaging. 2016 Oct-Dec;26(4):446-450. doi: 
      10.4103/0971-3026.195782.