PMID- 28105058
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20201001
IS  - 1741-427X (Print)
IS  - 1741-4288 (Electronic)
IS  - 1741-427X (Linking)
VI  - 2016
DP  - 2016
TI  - Preventive Effects of the Intestine Function Recovery Decoction, a Traditional 
      Chinese Medicine, on Postoperative Intra-Abdominal Adhesion Formation in a Rat 
      Model.
PG  - 1621894
LID - 10.1155/2016/1621894 [doi]
LID - 1621894
AB  - The intestine function recovery decoction (IFRD) is a traditional Chinese 
      medicine that has been used for the treatment of adhesive intestinal obstruction. 
      In this study, the preventative effects and probable mechanism of the IFRD were 
      investigated in a rat model. We randomly assigned rats to five groups: normal, 
      model, control, low dose IFRD, and high dose IFRD. In the animal model, the 
      caecum wall and parietal peritoneum were abraded to induce intra-abdominal 
      adhesion formation. Seven days after surgery, adhesion scores were assessed using 
      a visual scoring system, and histopathological samples were examined. The levels 
      of serum interleukin-6 (IL-6) and transforming growth factor beta-1 (TGF-beta1) were 
      analysed by an enzyme-linked immunosorbent assay (ELISA). The results showed that 
      a high dose of IFRD reduced the grade of intra-abdominal adhesion in rats. 
      Furthermore, the grades of inflammation, fibrosis, and neovascularization in the 
      high dose IFRD group were significantly lower than those in the control group. 
      The results indicate that the IFRD can prevent intra-abdominal adhesion formation 
      in a rat model. These data suggest that the IFRD may be an effective antiadhesion 
      agent.
FAU - Zhou, Cancan
AU  - Zhou C
AD  - Department of Hepatobiliary Surgery, The First Affiliated Hospital of Xi'an 
      Jiaotong University, Xi'an, Shaanxi 710061, China.
FAU - Jia, Pengbo
AU  - Jia P
AD  - Department of General Surgery, The First People's Hospital of Xianyang City, 
      Xianyang, Shaanxi 712000, China.
FAU - Jiang, Zhengdong
AU  - Jiang Z
AD  - Department of Hepatobiliary Surgery, The First Affiliated Hospital of Xi'an 
      Jiaotong University, Xi'an, Shaanxi 710061, China.
FAU - Chen, Ke
AU  - Chen K
AD  - Department of Hepatobiliary Surgery, The First Affiliated Hospital of Xi'an 
      Jiaotong University, Xi'an, Shaanxi 710061, China.
FAU - Wang, Guanghui
AU  - Wang G
AD  - Department of General Surgery, The First Affiliated Hospital of Xi'an Jiaotong 
      University, Xi'an, Shaanxi 710061, China.
FAU - Wang, Kang
AU  - Wang K
AD  - Department of General Surgery, The First Affiliated Hospital of Xi'an Jiaotong 
      University, Xi'an, Shaanxi 710061, China.
FAU - Wei, Guangbing
AU  - Wei G
AD  - Department of General Surgery, The First Affiliated Hospital of Xi'an Jiaotong 
      University, Xi'an, Shaanxi 710061, China.
FAU - Li, Xuqi
AU  - Li X
AUID- ORCID: 0000-0002-2497-020X
AD  - Department of General Surgery, The First Affiliated Hospital of Xi'an Jiaotong 
      University, Xi'an, Shaanxi 710061, China.
LA  - eng
PT  - Journal Article
DEP - 20161226
PL  - United States
TA  - Evid Based Complement Alternat Med
JT  - Evidence-based complementary and alternative medicine : eCAM
JID - 101215021
PMC - PMC5220493
COIS- The authors declare that there is no conflict of interests related to this work.
EDAT- 2017/01/21 06:00
MHDA- 2017/01/21 06:01
PMCR- 2016/12/26
CRDT- 2017/01/21 06:00
PHST- 2016/08/05 00:00 [received]
PHST- 2016/11/18 00:00 [revised]
PHST- 2016/12/05 00:00 [accepted]
PHST- 2017/01/21 06:00 [entrez]
PHST- 2017/01/21 06:00 [pubmed]
PHST- 2017/01/21 06:01 [medline]
PHST- 2016/12/26 00:00 [pmc-release]
AID - 10.1155/2016/1621894 [doi]
PST - ppublish
SO  - Evid Based Complement Alternat Med. 2016;2016:1621894. doi: 10.1155/2016/1621894. 
      Epub 2016 Dec 26.