PMID- 28105144
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20201001
IS  - 1792-0981 (Print)
IS  - 1792-1015 (Electronic)
IS  - 1792-0981 (Linking)
VI  - 12
IP  - 6
DP  - 2016 Dec
TI  - Sesamin attenuates allergic airway inflammation through the suppression of 
      nuclear factor-kappa B activation.
PG  - 4175-4181
LID - 10.3892/etm.2016.3903 [doi]
AB  - The aim of the present study is to determine the role of sesamin, the most 
      abundant lignan in sesame seed oil, on the regulation of allergic airway 
      inflammation in a murine asthma model. A BALB/c mouse model with allergic asthma 
      was used to evaluate the effects of sesamin on nuclear factor-kappa B (NF-kappaB) 
      activation. An enzyme-linked immunosorbent assay was used to determine protein 
      expression in bronchoalveolar lavage (BAL) fluids. Hematoxylin and eosin staining 
      was performed to examine histological changes. Moreover, western blot analysis 
      was used to detect the expression of proteins in tissues. Prior to administering 
      sesamin, the mice developed the following pathophysiological features of asthma: 
      An increase in the number of inflammatory cells, increased levels of interleukin 
      (IL)-4, IL-5 and IL-13, decreased levels of interferon-gamma in BAL fluids and lung 
      tissues, increased immunoglobulin E (IgE) levels in the serum and an increased 
      activation of NF-kappaB in lung tissues. Following treatment with sesamin, the mice 
      had evidently reduced peribronchiolar inflammation and airway inflammatory cell 
      recruitment, inhibited production of several cytokines in BAL fluids and lung 
      tissues, and decreased IgE levels. Following inhalation of ovalbumin, the 
      administration of sesamin also inhibited the activation of NF-kappaB. In addition, 
      sesamin administration reduced the phosphorylation of p38 mitogen-activated 
      protein kinases (MAPKs). The present study demonstrates that sesamin decreases 
      the activation of NF-kappaB in order to attenuate allergic airway inflammation in a 
      murine model of asthma, possibly via the regulation of phosphorylation of p38 
      MAPK. These observations provide an important molecular mechanism for the 
      potential use of sesamin in preventing and/or treating asthma, as well as other 
      airway inflammatory disorders.
FAU - Li, Liangchang
AU  - Li L
AD  - Department of Anatomy, Histology and Embryology, Yanbian University Medical 
      College, Yanji, Jilin 133002, P.R. China.
FAU - Piao, Hongmei
AU  - Piao H
AD  - Department of Respiratory Medicine, Yanbian University, Yanji, Jilin 133000, P.R. 
      China.
FAU - Zheng, Mingyu
AU  - Zheng M
AD  - Department of Respiratory Medicine, College of Pharmacy, Yanbian University, 
      Yanji, Jilin 133002, P.R. China.
FAU - Jin, Zhewu
AU  - Jin Z
AD  - Department of Anatomy, Histology and Embryology, Yanbian University Medical 
      College, Yanji, Jilin 133002, P.R. China.
FAU - Zhao, Liguang
AU  - Zhao L
AD  - Department of Anatomy, Histology and Embryology, Yanbian University Medical 
      College, Yanji, Jilin 133002, P.R. China.
FAU - Yan, Guanghai
AU  - Yan G
AD  - Department of Anatomy, Histology and Embryology, Yanbian University Medical 
      College, Yanji, Jilin 133002, P.R. China.
LA  - eng
PT  - Journal Article
DEP - 20161115
PL  - Greece
TA  - Exp Ther Med
JT  - Experimental and therapeutic medicine
JID - 101531947
PMC - PMC5228379
OTO - NOTNLM
OT  - Th2 cytokine
OT  - airway inflammation
OT  - asthma
OT  - nuclear factor-kappa B
OT  - sesamin
EDAT- 2017/01/21 06:00
MHDA- 2017/01/21 06:01
PMCR- 2016/11/15
CRDT- 2017/01/21 06:00
PHST- 2015/07/29 00:00 [received]
PHST- 2016/10/05 00:00 [accepted]
PHST- 2017/01/21 06:00 [entrez]
PHST- 2017/01/21 06:00 [pubmed]
PHST- 2017/01/21 06:01 [medline]
PHST- 2016/11/15 00:00 [pmc-release]
AID - ETM-0-0-3903 [pii]
AID - 10.3892/etm.2016.3903 [doi]
PST - ppublish
SO  - Exp Ther Med. 2016 Dec;12(6):4175-4181. doi: 10.3892/etm.2016.3903. Epub 2016 Nov 
      15.