PMID- 28105160
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20201001
IS  - 1792-1074 (Print)
IS  - 1792-1082 (Electronic)
IS  - 1792-1074 (Linking)
VI  - 12
IP  - 6
DP  - 2016 Dec
TI  - Folate deficiency and aberrant expression of cell adhesion molecule 1 are 
      potential indicators of prognosis in laryngeal squamous cell carcinoma.
PG  - 4510-4514
LID - 10.3892/ol.2016.5264 [doi]
AB  - The etiology of laryngeal squamous cell carcinoma (LSCC) has not yet been 
      adequately examined. Therefore, the present study aimed to investigate the 
      association between serum folate deficiency and abnormal expression of the cell 
      adhesion molecule 1 (CADM1) protein in the progression of LSCC. Samples were 
      collected from 60 patients with LSCC and 30 healthy people. Radioimmunoassays and 
      immunohistochemical staining were performed to measure serum folate levels and 
      CADM1 protein expression, respectively. The results demonstrated that CADM1 
      expression in LSCC specimens was significantly lower than in adjacent normal 
      tissues (chi(2)=28.229, P<0.001), which was associated with histological 
      differentiation and clinical stage (P=0.010 and 0.020, respectively). Levels of 
      serum folate in patients with LSCC were significantly lower than those observed 
      in healthy individuals (P=0.002). Furthermore, TSLCl expression and serum folate 
      levels were positively correlated in LSCC (r=0.642, P=0.001). Thus, the present 
      study determined that decreased CADM1 protein expression and low levels of serum 
      folate were correlated with an increased severity of LSCC.
FAU - Chang, Hao
AU  - Chang H
AD  - Department of Otolaryngology, The First Affiliated Hospital, College of Clinical 
      Medicine of Henan University of Science and Technology, Luoyang, Henan 471003, 
      P.R. China.
FAU - Ma, Min
AU  - Ma M
AD  - Department of Otolaryngology, The First Affiliated Hospital, College of Clinical 
      Medicine of Henan University of Science and Technology, Luoyang, Henan 471003, 
      P.R. China.
FAU - Ma, Rui
AU  - Ma R
AD  - Department of Central Laboratory, Eye & ENT Hospital of Fudan University, 
      Shanghai 200032, P.R. China.
FAU - Zhang, Chao
AU  - Zhang C
AD  - Department of Otolaryngology, The First Affiliated Hospital, College of Clinical 
      Medicine of Henan University of Science and Technology, Luoyang, Henan 471003, 
      P.R. China.
FAU - Zeng, Wei
AU  - Zeng W
AD  - Department of Otolaryngology, The First Affiliated Hospital, College of Clinical 
      Medicine of Henan University of Science and Technology, Luoyang, Henan 471003, 
      P.R. China.
FAU - Xing, Lu Qi
AU  - Xing LQ
AD  - Department of Pathology, The First Affiliated Hospital and College of Clinical 
      Medicine of Henan University of Science and Technology, Luoyang, Henan 471003, 
      P.R. China.
LA  - eng
PT  - Journal Article
DEP - 20161014
PL  - Greece
TA  - Oncol Lett
JT  - Oncology letters
JID - 101531236
PMC - PMC5228386
OTO - NOTNLM
OT  - cell adhesion molecule 1
OT  - folate
OT  - laryngeal squamous cell carcinoma
EDAT- 2017/01/21 06:00
MHDA- 2017/01/21 06:01
PMCR- 2016/10/14
CRDT- 2017/01/21 06:00
PHST- 2015/07/10 00:00 [received]
PHST- 2016/08/19 00:00 [accepted]
PHST- 2017/01/21 06:00 [entrez]
PHST- 2017/01/21 06:00 [pubmed]
PHST- 2017/01/21 06:01 [medline]
PHST- 2016/10/14 00:00 [pmc-release]
AID - OL-0-0-5264 [pii]
AID - 10.3892/ol.2016.5264 [doi]
PST - ppublish
SO  - Oncol Lett. 2016 Dec;12(6):4510-4514. doi: 10.3892/ol.2016.5264. Epub 2016 Oct 
      14.