PMID- 28105491
OWN - NLM
STAT- MEDLINE
DCOM- 20170828
LR  - 20181113
IS  - 1420-9071 (Electronic)
IS  - 1420-682X (Linking)
VI  - 74
IP  - 12
DP  - 2017 Jun
TI  - The multi-faceted role of retinoid X receptor in bone remodeling.
PG  - 2135-2149
LID - 10.1007/s00018-017-2458-4 [doi]
AB  - Retinoid X receptors (RXRs) form a unique subclass within the nuclear receptor 
      (NR) superfamily of ligand-dependent transcription factors. RXRs are obligatory 
      partners for a number of other NRs, placing RXRs in a coordinating role at the 
      crossroads of multiple signaling pathways. In addition, RXRs can function as 
      self-sufficient homodimers. Recent advances have revealed RXRs as novel 
      regulators of osteoclastogenesis and bone remodeling. This review outlines the 
      versatility of RXR action in the control of transcription of bone-forming 
      osteoblasts and bone-resorbing osteoclasts, both through heterodimerization with 
      other NRs and through RXR homodimerization. RXR signaling is currently a major 
      therapeutic target and, therefore, knowledge of how RXR signaling affects bone 
      remodeling creates enormous potential for the translation of basic research 
      findings into successful clinical therapies to increase bone mass and improve 
      bone quality.
FAU - Menendez-Gutierrez, Maria P
AU  - Menendez-Gutierrez MP
AD  - Centro Nacional de Investigaciones Cardiovasculares Carlos III (CNIC), Melchor 
      Fernandez Almagro, 3, 28029, Madrid, Spain.
FAU - Ricote, Mercedes
AU  - Ricote M
AUID- ORCID: 0000-0002-8090-8902
AD  - Centro Nacional de Investigaciones Cardiovasculares Carlos III (CNIC), Melchor 
      Fernandez Almagro, 3, 28029, Madrid, Spain. mricote@cnic.es.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20170119
PL  - Switzerland
TA  - Cell Mol Life Sci
JT  - Cellular and molecular life sciences : CMLS
JID - 9705402
RN  - 0 (Retinoid X Receptors)
SB  - IM
MH  - Animals
MH  - *Bone Remodeling
MH  - Bone Resorption/pathology
MH  - Humans
MH  - Models, Biological
MH  - Protein Multimerization
MH  - Retinoid X Receptors/*metabolism
OTO - NOTNLM
OT  - 9-cis retinoic acid
OT  - Agonists
OT  - Antagonists
OT  - Bexarotene
OT  - Bone resorption
OT  - Heterodimers
OT  - Homodimers
OT  - MAFB
OT  - Osteoporosis
OT  - Permissive
OT  - Rexinoids
OT  - Skeleton
EDAT- 2017/01/21 06:00
MHDA- 2017/08/29 06:00
CRDT- 2017/01/21 06:00
PHST- 2016/09/30 00:00 [received]
PHST- 2017/01/04 00:00 [accepted]
PHST- 2016/12/20 00:00 [revised]
PHST- 2017/01/21 06:00 [pubmed]
PHST- 2017/08/29 06:00 [medline]
PHST- 2017/01/21 06:00 [entrez]
AID - 10.1007/s00018-017-2458-4 [pii]
AID - 10.1007/s00018-017-2458-4 [doi]
PST - ppublish
SO  - Cell Mol Life Sci. 2017 Jun;74(12):2135-2149. doi: 10.1007/s00018-017-2458-4. 
      Epub 2017 Jan 19.