PMID- 28105599 OWN - NLM STAT- MEDLINE DCOM- 20170829 LR - 20181113 IS - 1867-108X (Electronic) IS - 1867-1071 (Linking) VI - 35 IP - 3 DP - 2017 Mar TI - T1 mapping using saturation recovery single-shot acquisition at 3-tesla magnetic resonance imaging in hypertrophic cardiomyopathy: comparison to late gadolinium enhancement. PG - 116-125 LID - 10.1007/s11604-017-0611-5 [doi] AB - PURPOSE: We evaluated the T1 values of segments and slices and the reproducibility in healthy controls, using saturation recovery single-shot acquisition (SASHA) at 3T magnetic resonance imaging. Moreover, we examined the difference in T1 values between hypertrophic cardiomyopathy (HCM) and healthy controls, and compared those with late gadolinium enhancement (LGE). MATERIALS AND METHODS: Twenty-one HCM patients and 10 healthy controls underwent T1 mapping before and after contrast administration. T1 values were measured in 12 segments. RESULTS: Native T1 values were significantly longer in HCM than in healthy controls [1373 ms (1312-1452 ms) vs. 1279 ms (1229-1326 ms); p < 0.0001]. Even in HCM segments without LGE, native T1 values were significantly longer than in healthy control segments [1366 ms (1300-1439 ms) vs. 1279 ms (1229-1326 ms); p < 0.0001]. Using a cutoff value of 1327 ms for septal native T1 values, we differentiated between HCM and healthy controls with 95% sensitivity, 90% specificity, 94% accuracy, and an area under the curve of 0.95. CONCLUSIONS: Native T1 values using a SASHA at 3T could differentiate HCM from healthy controls. Moreover, native T1 values have the potential to detect abnormal myocardium that cannot be identified adequately by LGE in HCM. FAU - Ogawa, Ryo AU - Ogawa R AD - Department of Radiology, Ehime University Graduate School of Medicine, Shitsukawa, Toon, Ehime, 791-0295, Japan. ogawa.ryo.th@ehime-u.ac.jp. FAU - Kido, Tomoyuki AU - Kido T AD - Department of Radiology, Ehime University Graduate School of Medicine, Shitsukawa, Toon, Ehime, 791-0295, Japan. FAU - Nakamura, Masashi AU - Nakamura M AD - Department of Radiology, Ehime University Graduate School of Medicine, Shitsukawa, Toon, Ehime, 791-0295, Japan. FAU - Kido, Teruhito AU - Kido T AD - Department of Radiology, Ehime University Graduate School of Medicine, Shitsukawa, Toon, Ehime, 791-0295, Japan. FAU - Kurata, Akira AU - Kurata A AD - Department of Radiology, Ehime University Graduate School of Medicine, Shitsukawa, Toon, Ehime, 791-0295, Japan. FAU - Uetani, Teruyoshi AU - Uetani T AD - Department of Cardiovascular Internal Medicine, Ehime University Graduate School of Medicine, Shitsukawa, Toon, Ehime, 791-0295, Japan. FAU - Ogimoto, Akiyoshi AU - Ogimoto A AD - Department of Cardiovascular Internal Medicine, Ehime University Graduate School of Medicine, Shitsukawa, Toon, Ehime, 791-0295, Japan. FAU - Miyagawa, Masao AU - Miyagawa M AD - Department of Radiology, Ehime University Graduate School of Medicine, Shitsukawa, Toon, Ehime, 791-0295, Japan. FAU - Mochizuki, Teruhito AU - Mochizuki T AD - Department of Radiology, Ehime University Graduate School of Medicine, Shitsukawa, Toon, Ehime, 791-0295, Japan. LA - eng PT - Comparative Study PT - Journal Article DEP - 20170119 PL - Japan TA - Jpn J Radiol JT - Japanese journal of radiology JID - 101490689 RN - AU0V1LM3JT (Gadolinium) SB - IM MH - Adult MH - Aged MH - Cardiomyopathy, Hypertrophic/*diagnostic imaging MH - Case-Control Studies MH - Female MH - *Gadolinium MH - Humans MH - Magnetic Resonance Imaging/*methods MH - Male MH - Middle Aged OTO - NOTNLM OT - 3-Tesla magnetic resonance imaging OT - Hypertrophic cardiomyopathy OT - Native T1 OT - Saturation recovery single-shot acquisition OT - T1 mapping EDAT- 2017/01/21 06:00 MHDA- 2017/08/30 06:00 CRDT- 2017/01/21 06:00 PHST- 2016/08/09 00:00 [received] PHST- 2017/01/02 00:00 [accepted] PHST- 2017/01/21 06:00 [pubmed] PHST- 2017/08/30 06:00 [medline] PHST- 2017/01/21 06:00 [entrez] AID - 10.1007/s11604-017-0611-5 [pii] AID - 10.1007/s11604-017-0611-5 [doi] PST - ppublish SO - Jpn J Radiol. 2017 Mar;35(3):116-125. doi: 10.1007/s11604-017-0611-5. Epub 2017 Jan 19.