PMID- 28105762
OWN - NLM
STAT- MEDLINE
DCOM- 20180427
LR  - 20210109
IS  - 1098-2825 (Electronic)
IS  - 0887-8013 (Print)
IS  - 0887-8013 (Linking)
VI  - 31
IP  - 6
DP  - 2017 Nov
TI  - Establishment of reference intervals for complete blood count parameters during 
      normal pregnancy in Beijing.
LID - 10.1002/jcla.22150 [doi]
LID - e22150
AB  - OBJECTIVE: To observe the changes of complete blood count (CBC) parameters during 
      pregnancy and establish appropriate reference intervals for healthy pregnant 
      women. METHODS: Healthy pregnant women took the blood tests at all trimesters. 
      All blood samples were processed on Sysmex XE-2100. The following CBC parameters 
      were analyzed: red blood cell count (RBC), hemoglobin (Hb), hematocrit (Hct), 
      mean corpuscular volume (MCV), mean corpuscular hemoglobin (MCH), mean 
      corpuscular hemoglobin concentration (MCHC), red blood cell distribution width 
      (RDW), platelet count (PLT), mean platelet volume (MPV), platelet distribution 
      width (PDW), white blood cell count (WBC), and leukocyte differential count. 
      Reference intervals were established using the 2.5th and 97.5th percentile of the 
      distribution. RESULTS: Complete blood count parameters showed dynamic changes 
      during trimesters. RBC, Hb, Hct declined at trimester 1, reaching their lowest 
      point at trimester 2, and began to rise again at trimester 3. WBC, neutrophil 
      count (Neut), monocyte count (MONO), RDW, and PDW went up from trimester 1 to 
      trimester 3. On the contrary, MCHC, lymphocyte count (LYMPH), PLT, and MPV 
      gradually descended during pregnancy. There were statistical significances in all 
      CBC parameters between pregnant women and normal women, regardless of the 
      trimesters (P<.001). The median obtained were (normal vs pregnancy) as follows: 
      RBC 4.50 vs 3.94x10(12) /L, Hb 137 vs 120 g/L, WBC 5.71 vs 9.06x10(9) /L, LYMPH% 
      32.2 vs 18.0, Neut% 58.7 vs 75.0, and PLT 251 vs 202x10(9) /L. CONCLUSION: The 
      changes of CBC parameters during pregnancy are described, and reference intervals 
      for Beijing pregnant women are demonstrated in this study.
CI  - (c) 2017 Wiley Periodicals, Inc.
FAU - Li, Aiwei
AU  - Li A
AUID- ORCID: 0000-0003-1079-7511
AD  - Department of Laboratory Medicine, Peking University Third Hospital, Beijing, 
      China.
FAU - Yang, Shuo
AU  - Yang S
AD  - Department of Laboratory Medicine, Peking University Third Hospital, Beijing, 
      China.
FAU - Zhang, Jie
AU  - Zhang J
AD  - Department of Laboratory Medicine, Peking University Third Hospital, Beijing, 
      China.
FAU - Qiao, Rui
AU  - Qiao R
AD  - Department of Laboratory Medicine, Peking University Third Hospital, Beijing, 
      China.
LA  - eng
PT  - Journal Article
DEP - 20170120
PL  - United States
TA  - J Clin Lab Anal
JT  - Journal of clinical laboratory analysis
JID - 8801384
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Beijing/epidemiology
MH  - Blood Cell Count/*standards
MH  - Female
MH  - Humans
MH  - Middle Aged
MH  - *Pregnancy/blood/statistics & numerical data
MH  - Pregnancy Complications, Hematologic
MH  - Prenatal Care
MH  - Reference Values
MH  - Young Adult
PMC - PMC6816986
OTO - NOTNLM
OT  - complete blood count
OT  - pregnancy
OT  - reference interval
EDAT- 2017/01/21 06:00
MHDA- 2018/04/28 06:00
PMCR- 2017/01/20
CRDT- 2017/01/21 06:00
PHST- 2016/11/07 00:00 [received]
PHST- 2016/12/23 00:00 [accepted]
PHST- 2017/01/21 06:00 [pubmed]
PHST- 2018/04/28 06:00 [medline]
PHST- 2017/01/21 06:00 [entrez]
PHST- 2017/01/20 00:00 [pmc-release]
AID - JCLA22150 [pii]
AID - 10.1002/jcla.22150 [doi]
PST - ppublish
SO  - J Clin Lab Anal. 2017 Nov;31(6):e22150. doi: 10.1002/jcla.22150. Epub 2017 Jan 
      20.