PMID- 28107084
OWN - NLM
STAT- MEDLINE
DCOM- 20170222
LR  - 20170222
IS  - 1532-4192 (Electronic)
IS  - 0735-7907 (Linking)
VI  - 35
IP  - 2
DP  - 2017 Feb 7
TI  - Can Diffusion-Weighted Imaging and Related Apparent Diffusion Coefficient be a 
      Prognostic Value in Women With Breast Cancer?
PG  - 92-99
LID - 10.1080/07357907.2016.1267740 [doi]
AB  - PURPOSE: To analyze diffusion-weighted imaging (DWI) and the related apparent 
      diffusion coefficient (ADC) in women with breast cancer, correlating these values 
      with the presence at 3 years of distant metastases, and to demonstrate that 
      DWI-Magnetic Resonance Imaging (MRI) and related ADC values may represent a 
      prognostic value in the study of women with breast cancer. MATERIALS AND METHODS: 
      Sixty women (aged 45-73 years) affected with breast cancer with a follow-up in 
      3 years were enrolled. On DWI, we obtained the ADC values, and these were 
      correlated with the clinical condition of patients at 3 years. Moreover, tumour 
      size, lymph node status, and molecular markers, including estrogens receptor, 
      progesterone receptor, Ki-67 index, and human growth factor receptor 2 protein, 
      were correlated with ADC values. This study was approved by the Scientific 
      Committee of our institution. RESULTS: We considered patients with metastasis at 
      3 years (12 patients - 20%) and without metastasis (48 patients - 80%). The mean 
      ADC value in patients with no metastases at 3 years was 1.06 +/- 0.38, while for 
      patients with metastases it was 0.74 +/- 0.34 (p = .011). The receiver-operator 
      curve analysis identified a value of 0.75 (<0.75 with risk to develop metastasis) 
      as the best predictive cutoff for ADC values, with the highest sensitivity 
      (81.25%) and higher specificity (66.67%). After regression analysis, ADC value, 
      positivity to estrogen-progestin receptors, and presence of lymph nodes were the 
      only prognostic factors found to be statistically significant. CONCLUSIONS: 
      DWI-MRI and related ADC values may represent a prognostic value in women with 
      breast cancer.
FAU - Rabasco, Paola
AU  - Rabasco P
AD  - a Department of Radiology , IRCCS - Referral Cancer Center of Basilicata , 
      Rionero in Vulture, Italy.
FAU - Caivano, Rocchina
AU  - Caivano R
AD  - b Department of Radiation Oncology , IRCCS - Referral Cancer Center of Basilicata 
      , Rionero in Vulture, Italy.
FAU - Simeon, Vittorio
AU  - Simeon V
AD  - c Laboratory of Pre-Clinical and Translational Research , IRCCS - Referral Cancer 
      Center of Basilicata , Rionero in Vulture, Italy.
FAU - Dinardo, Giuseppina
AU  - Dinardo G
AD  - a Department of Radiology , IRCCS - Referral Cancer Center of Basilicata , 
      Rionero in Vulture, Italy.
FAU - Lotumolo, Antonella
AU  - Lotumolo A
AD  - a Department of Radiology , IRCCS - Referral Cancer Center of Basilicata , 
      Rionero in Vulture, Italy.
FAU - Gioioso, Matilde
AU  - Gioioso M
AD  - a Department of Radiology , IRCCS - Referral Cancer Center of Basilicata , 
      Rionero in Vulture, Italy.
FAU - Villonio, Antonio
AU  - Villonio A
AD  - a Department of Radiology , IRCCS - Referral Cancer Center of Basilicata , 
      Rionero in Vulture, Italy.
FAU - Iannelli, Giancarlo
AU  - Iannelli G
AD  - a Department of Radiology , IRCCS - Referral Cancer Center of Basilicata , 
      Rionero in Vulture, Italy.
FAU - D'Antuono, Felice
AU  - D'Antuono F
AD  - a Department of Radiology , IRCCS - Referral Cancer Center of Basilicata , 
      Rionero in Vulture, Italy.
FAU - Zandolino, Alexis
AU  - Zandolino A
AD  - a Department of Radiology , IRCCS - Referral Cancer Center of Basilicata , 
      Rionero in Vulture, Italy.
FAU - Macarini, Luca
AU  - Macarini L
AD  - d Department of Radiology , University of Foggia , Foggia , Italy.
FAU - Guglielmi, Giuseppe
AU  - Guglielmi G
AD  - d Department of Radiology , University of Foggia , Foggia , Italy.
AD  - e Department of Radiology , Scientific Institute Hospital , "Casa Sollievodella 
      Sofferenza," San Giovanni Rotondo, Italy.
FAU - Cammarota, Aldo
AU  - Cammarota A
AD  - a Department of Radiology , IRCCS - Referral Cancer Center of Basilicata , 
      Rionero in Vulture, Italy.
LA  - eng
PT  - Journal Article
DEP - 20170120
PL  - England
TA  - Cancer Invest
JT  - Cancer investigation
JID - 8307154
SB  - IM
MH  - Aged
MH  - Breast Neoplasms/*diagnostic imaging/pathology
MH  - Carcinoma, Ductal, Breast/*diagnostic imaging/pathology
MH  - Diffusion Magnetic Resonance Imaging/*methods
MH  - Female
MH  - Humans
MH  - Lymphatic Metastasis
MH  - Middle Aged
MH  - Predictive Value of Tests
MH  - Prognosis
MH  - Retrospective Studies
OTO - NOTNLM
OT  - Breast cancer
OT  - apparent diffusion coefficient
OT  - diffusion-weighted imaging
OT  - magnetic resonance imaging
OT  - prognostic factors
EDAT- 2017/01/21 06:00
MHDA- 2017/02/23 06:00
CRDT- 2017/01/21 06:00
PHST- 2017/01/21 06:00 [pubmed]
PHST- 2017/02/23 06:00 [medline]
PHST- 2017/01/21 06:00 [entrez]
AID - 10.1080/07357907.2016.1267740 [doi]
PST - ppublish
SO  - Cancer Invest. 2017 Feb 7;35(2):92-99. doi: 10.1080/07357907.2016.1267740. Epub 
      2017 Jan 20.