PMID- 28107582
OWN - NLM
STAT- MEDLINE
DCOM- 20180315
LR  - 20180315
IS  - 1601-0825 (Electronic)
IS  - 1354-523X (Linking)
VI  - 23
IP  - 4
DP  - 2017 May
TI  - Immunoexpression of HDAC1, HDAC2, and HAT1 in actinic cheilitis and lip squamous 
      cell carcinoma.
PG  - 505-510
LID - 10.1111/odi.12641 [doi]
AB  - BACKGROUND: Acetylation and deacetylation are the most studied covalent histone 
      modifications resulting in transcriptional regulation with histone deacetylases 
      (HDAC) and histone acetyltransferases (HAT) as the main associated enzymes. These 
      enzymes overexpression induces abnormal transcription of key genes that regulate 
      important cellular functions, such as proliferation, cell cycle regulation, and 
      apoptosis. Thus, the expression of different HATs and HDACs has been evaluated in 
      various cancers. OBJECTIVE: To investigate HDAC1, HDAC2 and HAT1 expression in 
      lip squamous cell carcinoma (LSCC) and actinic cheilitis (AC) and to demonstrate 
      their correlation with DNA metyltransferases (DNMTs). MATERIAL AND METHODS: 
      Thirty cases of lip squamous cell carcinoma (LSCC), thirty cases of actinic 
      cheilitis (AC), and 28 cases of non-neoplastic epithelium as control were 
      selected for immunohistochemical investigation. RESULTS: Nuclear HDAC2 
      immunopositivity was significantly higher in AC (75.07% +/- 29.70) when compared 
      with LSCC (51.06% +/- 39.02). HDAC1 and HAT1 nuclear immunostaining were higher in 
      AC, with no statistical significance. When comparing data with our previous 
      study, we found a positive correlation between HDAC1 X DNMT1/DNMT3b, HDAC2 X 
      DNMT3b, and HAT1 X DNMT1/DNMT3b for certain studied groups. CONCLUSION: This 
      study showed higher levels of nuclear HDAC2 immunopositivity in AC, possibly 
      indicating that this enzyme plays a key role in lip photocarcinogenesis early 
      stages.
CI  - (c) 2017 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.
FAU - Chrun, E S
AU  - Chrun ES
AUID- ORCID: 0000-0001-5569-9371
AD  - Federal University of Santa Catarina, Florianopolis, Santa Catarina, Brazil.
FAU - Modolo, F
AU  - Modolo F
AD  - Pathology Department and Dentistry Graduate Program, Federal University of Santa 
      Catarina, Florianopolis, SC, Brazil.
FAU - Vieira, Dsc
AU  - Vieira D
AD  - Pathology Department, Federal University of Santa Catarina, Florianopolis, SC, 
      Brazil.
FAU - Borges-Junior, Als
AU  - Borges-Junior A
AD  - Federal University of Santa Catarina, Florianopolis, Santa Catarina, Brazil.
FAU - Castro, R G
AU  - Castro RG
AD  - Dentistry Department, Federal University of Santa Catarina, Florianopolis, Santa 
      Catarina, Brazil.
FAU - Daniel, F I
AU  - Daniel FI
AD  - Pathology Department and Dentistry Graduate Program, Federal University of Santa 
      Catarina, Florianopolis, SC, Brazil.
LA  - eng
PT  - Journal Article
DEP - 20170309
PL  - Denmark
TA  - Oral Dis
JT  - Oral diseases
JID - 9508565
RN  - 0 (Biomarkers, Tumor)
RN  - EC 2.1.1.- (DNA Modification Methylases)
RN  - EC 2.3.1.48 (Histone Acetyltransferases)
RN  - EC 2.3.1.48 (histone acetyltransferase type B complex)
RN  - EC 3.5.1.98 (HDAC1 protein, human)
RN  - EC 3.5.1.98 (HDAC2 protein, human)
RN  - EC 3.5.1.98 (Histone Deacetylase 1)
RN  - EC 3.5.1.98 (Histone Deacetylase 2)
RN  - Actinic cheilitis
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Biomarkers, Tumor/*metabolism
MH  - Carcinoma, Squamous Cell/*enzymology
MH  - Case-Control Studies
MH  - Cheilitis/*enzymology
MH  - Child
MH  - Child, Preschool
MH  - DNA Modification Methylases/metabolism
MH  - Female
MH  - Histone Acetyltransferases/*metabolism
MH  - Histone Deacetylase 1/*metabolism
MH  - Histone Deacetylase 2/*metabolism
MH  - Humans
MH  - Immunohistochemistry
MH  - Lip Neoplasms/*enzymology
MH  - Male
MH  - Middle Aged
MH  - Young Adult
OTO - NOTNLM
OT  - actinic cheilitis
OT  - histone acetyltransferases
OT  - histone deacetylases
OT  - immunohistochemistry
OT  - lip neoplasms
OT  - squamous cell carcinoma
EDAT- 2017/01/21 06:00
MHDA- 2018/03/16 06:00
CRDT- 2017/01/21 06:00
PHST- 2016/11/07 00:00 [received]
PHST- 2017/01/05 00:00 [revised]
PHST- 2017/01/06 00:00 [accepted]
PHST- 2017/01/21 06:00 [pubmed]
PHST- 2018/03/16 06:00 [medline]
PHST- 2017/01/21 06:00 [entrez]
AID - 10.1111/odi.12641 [doi]
PST - ppublish
SO  - Oral Dis. 2017 May;23(4):505-510. doi: 10.1111/odi.12641. Epub 2017 Mar 9.