PMID- 28108330
OWN - NLM
STAT- MEDLINE
DCOM- 20180402
LR  - 20180419
IS  - 1873-6815 (Electronic)
IS  - 0531-5565 (Linking)
VI  - 94
DP  - 2017 Aug
TI  - Pleiotropic responses to methionine restriction.
PG  - 83-88
LID - S0531-5565(17)30045-1 [pii]
LID - 10.1016/j.exger.2017.01.012 [doi]
AB  - Methionine restriction (MR) extends lifespan across different species. The main 
      responses of rodent models to MR are well-documented in adipose tissue (AT) and 
      liver, which have reduced mass and improved insulin sensitivity, respectively. 
      Recently, molecular mechanisms that improve healthspan have been identified in 
      both organs during MR. In fat, MR induced a futile lipid cycle concomitant with 
      beige AT accumulation, producing elevated energy expenditure. In liver, MR 
      upregulated fibroblast growth factor 21 and improved glucose metabolism in aged 
      mice and in response to a high-fat diet. Furthermore, MR also reduces 
      mitochondrial oxidative stress in various organs such as liver, heart, kidneys, 
      and brain. Other effects of MR have also been reported in such areas as cardiac 
      function in response to hyperhomocysteinemia (HHcy), identification of molecular 
      mechanisms in bone development, and enhanced epithelial tight junction. In 
      addition, rodent models of cancer responded positively to MR, as has been 
      reported in colon, prostate, and breast cancer studies. The beneficial effects of 
      MR have also been documented in a number of invertebrate model organisms, 
      including yeast, nematodes, and fruit flies. MR not only promotes extended 
      longevity in these organisms, but in the case of yeast has also been shown to 
      improve stress tolerance. In addition, expression analyses of yeast and 
      Drosophila undergoing MR have identified multiple candidate mediators of the 
      beneficial effects of MR in these models. In this review, we emphasize other in 
      vivo effects of MR such as in cardiovascular function, bone development, 
      epithelial tight junction, and cancer. We also discuss the effects of MR in 
      invertebrates.
CI  - Copyright (c) 2017 The Authors. Published by Elsevier Inc. All rights reserved.
FAU - Ables, Gene P
AU  - Ables GP
AD  - Orentreich Foundation for the Advancement of Science, Inc., 855 Route 301, Cold 
      Spring, NY 10516, USA. Electronic address: gables@orentreich.org.
FAU - Johnson, Jay E
AU  - Johnson JE
AD  - Orentreich Foundation for the Advancement of Science, Inc., 855 Route 301, Cold 
      Spring, NY 10516, USA.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20170117
PL  - England
TA  - Exp Gerontol
JT  - Experimental gerontology
JID - 0047061
RN  - AE28F7PNPL (Methionine)
SB  - IM
MH  - Aging/genetics/*metabolism/pathology
MH  - Animals
MH  - Bone Development
MH  - Caenorhabditis elegans/growth & development/metabolism
MH  - Cardiovascular System/metabolism
MH  - Drosophila melanogaster/growth & development/metabolism
MH  - Epithelial Cells/metabolism
MH  - Gene Expression Regulation
MH  - Humans
MH  - *Longevity
MH  - Methionine/*deficiency
MH  - Neoplasms/metabolism/pathology
MH  - Stress, Physiological
MH  - Tight Junctions/metabolism
MH  - Yeasts/growth & development/metabolism
OTO - NOTNLM
OT  - Bone
OT  - Cancer
OT  - Cardiovascular
OT  - Invertebrates
OT  - Lifespan extension
OT  - Methionine restriction
OT  - Yeast
EDAT- 2017/01/22 06:00
MHDA- 2018/04/03 06:00
CRDT- 2017/01/22 06:00
PHST- 2017/01/22 06:00 [pubmed]
PHST- 2018/04/03 06:00 [medline]
PHST- 2017/01/22 06:00 [entrez]
AID - S0531-5565(17)30045-1 [pii]
AID - 10.1016/j.exger.2017.01.012 [doi]
PST - ppublish
SO  - Exp Gerontol. 2017 Aug;94:83-88. doi: 10.1016/j.exger.2017.01.012. Epub 2017 Jan 
      17.