PMID- 2810865
OWN - NLM
STAT- MEDLINE
DCOM- 19891215
LR  - 20190919
IS  - 0021-5082 (Print)
IS  - 0021-5082 (Linking)
VI  - 44
IP  - 2
DP  - 1989 Jun
TI  - [Studies on stroke-prone spontaneously hypertensive rats (SHRSP) fed a high-fat 
      and high-cholesterol diet--effect of taurine on serum lipoprotein metabolism in 
      hypercholesterolemic rats].
PG  - 648-58
AB  - It is well known that taurine, a final metabolite of sulfur-containing amino 
      acids, plays an important role in bile acid metabolism and that it also has a 
      moderately hypotensive effect. Moreover, it has recently been revealed that 
      taurine shows a hypocholesterolemic effect in animals with experimentally induced 
      hypercholesterolemia. However, the hypocholesterolemic mechanism remains 
      unresolved. Stroke-prone spontaneously hypertensive rats (SHRSP) easily develop 
      hypercholesterolemia when fed a high-fat and high-cholesterol diet (HFC diet). In 
      our previous paper, we reported changes in the concentrations and distributions 
      of serum lipoproteins and apolipoproteins in hypercholesterolemic SHRSP and Kyo: 
      Wistar rats (WKY) induced by HFC feeding. In this paper, to elucidate the 
      mechanism of the hypocholesterolemic effect of taurine, we investigated the 
      effects of taurine on concentrations and distributions of serum lipoproteins and 
      apolipoproteins in hypercholesterolemic SHRSP and WKY induced by HFC feeding. The 
      results obtained were as follows: 1) The hypocholesterolemic effect of taurine in 
      hypercholesterolemic SHRSP was remarkable in comparison with that in 
      hypercholesterolemic WKY. 2) The hypocholesterolemic effect of taurine was mainly 
      due to a marked suppression of extreme elevations of cholesterol contents in the 
      VLDL and IDL fractions of both strains. This was associated with a decrease in 
      the elevated contents of apo B and apo E which are major components of VLDL and 
      IDL. This suppressive effect was more obvious in SHRSP than in WKY, which 
      explains the greater hypocholesterolemic effect of taurine in SHRSP. It could be 
      that, as a result of taurine administration, the catabolism of cholesterol to 
      bile acid in the liver is accelerated, followed by a decrease of the hepatic 
      cholesterol pool, resulting in a suppression of the synthesis and/or secretion of 
      VLDL (beta-VLDL) in the liver. 3) The hypocholesterolemic effect of taurine was 
      also observed in the LDL fractions of both strains, but the effect was not as 
      strong as that observed in the VLDL and IDL fractions. This effect might be 
      attributable to suppression of the synthesis and/or secretion of LDL in the liver 
      and a decrease in the elevated content of apo E HDL (HDLc) which spans two 
      density fractions (the LDL and HDL fractions). 4) In HDL fractions of both 
      strains, the decreased content of apo E HDL (HDL1 and HDLc) was even lower, 
      whereas the decreased apo A-I content in the HDL fraction of SHRSP was 
      significantly restored and the cholesterol level was slightly elevated.(ABSTRACT 
      TRUNCATED AT 400 WORDS)
FAU - Ogawa, H
AU  - Ogawa H
FAU - Nishikawa, T
AU  - Nishikawa T
FAU - Fukushima, S
AU  - Fukushima S
FAU - Sasagawa, S
AU  - Sasagawa S
LA  - jpn
PT  - English Abstract
PT  - Journal Article
PL  - Japan
TA  - Nihon Eiseigaku Zasshi
JT  - Nihon eiseigaku zasshi. Japanese journal of hygiene
JID - 0417457
RN  - 0 (Cholesterol, Dietary)
RN  - 0 (Dietary Fats)
RN  - 0 (Lipoproteins)
RN  - 1EQV5MLY3D (Taurine)
SB  - IM
MH  - Animals
MH  - Cerebrovascular Disorders/*etiology
MH  - Cholesterol, Dietary/*administration & dosage
MH  - Dietary Fats/*administration & dosage
MH  - Hypercholesterolemia/*blood
MH  - Lipoproteins/*blood
MH  - Male
MH  - Rats
MH  - Rats, Inbred SHR
MH  - Rats, Inbred WKY
MH  - Taurine/*pharmacology
EDAT- 1989/06/01 00:00
MHDA- 1989/06/01 00:01
CRDT- 1989/06/01 00:00
PHST- 1989/06/01 00:00 [pubmed]
PHST- 1989/06/01 00:01 [medline]
PHST- 1989/06/01 00:00 [entrez]
AID - 10.1265/jjh.44.648 [doi]
PST - ppublish
SO  - Nihon Eiseigaku Zasshi. 1989 Jun;44(2):648-58. doi: 10.1265/jjh.44.648.