PMID- 28109009
OWN - NLM
STAT- MEDLINE
DCOM- 20171102
LR  - 20171102
IS  - 1550-9613 (Electronic)
IS  - 0278-4297 (Linking)
VI  - 36
IP  - 5
DP  - 2017 May
TI  - Using Flow Characteristics in Three-Dimensional Power Doppler Ultrasound Imaging 
      to Predict Complete Responses in Patients Undergoing Neoadjuvant Chemotherapy.
PG  - 887-900
LID - 10.7863/ultra.16.02078 [doi]
AB  - OBJECTIVES: Strategies are needed for the identification of a poor response to 
      treatment and determination of appropriate chemotherapy strategies for patients 
      in the early stages of neoadjuvant chemotherapy for breast cancer. We hypothesize 
      that power Doppler ultrasound imaging can provide useful information on 
      predicting response to neoadjuvant chemotherapy. METHODS: The solid directional 
      flow of vessels in breast tumors was used as a marker of pathologic complete 
      responses (pCR) in patients undergoing neoadjuvant chemotherapy. Thirty-one 
      breast cancer patients who received neoadjuvant chemotherapy and had tumors of 2 
      to 5 cm were recruited. Three-dimensional power Doppler ultrasound with 
      high-definition flow imaging technology was used to acquire the indices of tumor 
      blood flow/volume, and the chemotherapy response prediction was established, 
      followed by support vector machine classification. RESULTS: The accuracy of pCR 
      prediction before the first chemotherapy treatment was 83.87% (area under the ROC 
      curve [AUC] = 0.6957). After the second chemotherapy treatment, the accuracy of 
      was 87.9% (AUC = 0.756). Trend analysis showed that good and poor responders 
      exhibited different trends in vascular flow during chemotherapy. CONCLUSIONS: 
      This preliminary study demonstrates the feasibility of using the vascular flow in 
      breast tumors to predict chemotherapeutic efficacy.
CI  - (c) 2017 by the American Institute of Ultrasound in Medicine.
FAU - Shia, Wei-Chung
AU  - Shia WC
AD  - Cancer Research Center, Changhua Christian Hospital, Changhua, Taiwan.
FAU - Huang, Yu-Len
AU  - Huang YL
AD  - Department of Computer Science, Tunghai University, Taichung, Taiwan.
FAU - Wu, Hwa-Koon
AU  - Wu HK
AD  - Department of Medical Imaging, Changhua Christian Hospital, Changhua, Taiwan.
FAU - Chen, Dar-Ren
AU  - Chen DR
AD  - Comprehensive Breast Cancer Center, Changhua Christian Hospital, Changhua, 
      Taiwan.
LA  - eng
PT  - Journal Article
DEP - 20170121
PL  - England
TA  - J Ultrasound Med
JT  - Journal of ultrasound in medicine : official journal of the American Institute of 
      Ultrasound in Medicine
JID - 8211547
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Breast/blood supply/diagnostic imaging
MH  - Breast Neoplasms/blood supply/*diagnostic imaging/*drug therapy
MH  - Chemotherapy, Adjuvant
MH  - Female
MH  - Humans
MH  - Imaging, Three-Dimensional/*methods
MH  - Middle Aged
MH  - Neoadjuvant Therapy/*methods
MH  - Predictive Value of Tests
MH  - Reproducibility of Results
MH  - Retrospective Studies
MH  - Treatment Outcome
MH  - Ultrasonography, Doppler/*methods
OTO - NOTNLM
OT  - Doppler ultrasound imaging
OT  - breast cancer
OT  - clinical prediction rule
OT  - neoadjuvant therapy
EDAT- 2017/01/22 06:00
MHDA- 2017/11/03 06:00
CRDT- 2017/01/22 06:00
PHST- 2016/03/09 00:00 [received]
PHST- 2016/07/05 00:00 [accepted]
PHST- 2017/01/22 06:00 [pubmed]
PHST- 2017/11/03 06:00 [medline]
PHST- 2017/01/22 06:00 [entrez]
AID - 10.7863/ultra.16.02078 [doi]
PST - ppublish
SO  - J Ultrasound Med. 2017 May;36(5):887-900. doi: 10.7863/ultra.16.02078. Epub 2017 
      Jan 21.