PMID- 28109991
OWN - NLM
STAT- MEDLINE
DCOM- 20170815
LR  - 20220419
IS  - 1525-5069 (Electronic)
IS  - 1525-5050 (Linking)
VI  - 68
DP  - 2017 Mar
TI  - Clinical characteristics, treatments, and outcomes of patients with 
      anti-N-methyl-d-aspartate receptor encephalitis: A systematic review of reported 
      cases.
PG  - 57-65
LID - S1525-5050(16)30608-4 [pii]
LID - 10.1016/j.yebeh.2016.12.019 [doi]
AB  - Anti-N-methyl-d-aspartate receptor (NMDAR) encephalitis is a recently recognized 
      autoimmune disorder which is responsive to immunotherapy. However, the outcomes 
      of different immunotherapies have not been defined and there have been few 
      studies that carried out a comparison among them. To provide an overview of the 
      clinical characteristics, treatments, and outcomes of anti-NMDAR encephalitis, we 
      systematically reviewed the literature in the PubMed, Medline, Embase, Cochrane 
      Library, BioMedical Literature Database (CBM), China National Knowledge 
      Infrastructure (CNKI), and Wan-fang databases. Eighty-three studies with a total 
      of 432 patients were included. The median age was 22years. Two hundred 
      ninety-three (68%) patients were female, 87 (21%) of 412 patients had a tumor, 
      including 68 (78%) patients with ovarian teratoma. Pediatric patients had a 
      higher ratio of seizures to psychiatric symptoms as the initial manifestation 
      (p=0.0012), a lower proportion with a tumor (p<0.0001) and CSF pleocytosis 
      (p=0.0163), and a better outcome (p=0.0064) than adults. Patients who died had a 
      higher proportion of CSF pleocytosis than the patients who survived (p=0.0021). 
      There were no significant differences among three first-line immunotherapy used 
      alone (p=0.9172) or among combinations of every two of them (p=0.3059). With 
      regard to the use of corticosteroid and IVIG, there were no significant 
      differences between the outcomes of early combined treatment and sequential 
      treatment (p=0.7277), or between using corticosteroid first and IVIG first 
      (p=0.5422). Our findings suggest that the clinical characteristics and outcomes 
      for pediatric patients were different from adult patients, and no significant 
      differences were found among different immunotherapies.
CI  - Copyright (c) 2016 Elsevier Inc. All rights reserved.
FAU - Zhang, Le
AU  - Zhang L
AD  - Department of Neurology, West China Hospital, Sichuan University, Chengdu, 
      Sichuan Province, China.
FAU - Wu, Meng-Qian
AU  - Wu MQ
AD  - Department of Neurology, West China Hospital, Sichuan University, Chengdu, 
      Sichuan Province, China.
FAU - Hao, Zi-Long
AU  - Hao ZL
AD  - Department of Neurology, West China Hospital, Sichuan University, Chengdu, 
      Sichuan Province, China.
FAU - Chiang, Siew Mun Vance
AU  - Chiang SM
AD  - West China College of Medicine, Sichuan University, Chengdu, Sichuan Province, 
      China.
FAU - Shuang, Kun
AU  - Shuang K
AD  - West China College of Medicine, Sichuan University, Chengdu, Sichuan Province, 
      China.
FAU - Lin, Min-Tao
AU  - Lin MT
AD  - West China College of Medicine, Sichuan University, Chengdu, Sichuan Province, 
      China.
FAU - Chi, Xiao-Sa
AU  - Chi XS
AD  - Department of Neurology, West China Hospital, Sichuan University, Chengdu, 
      Sichuan Province, China.
FAU - Fang, Jia-Jia
AU  - Fang JJ
AD  - Department of Neurology, Fourth Affiliated Hospital, School of Medicine, Zhejiang 
      University, Yiwu, Zhejiang Province, China.
FAU - Zhou, Dong
AU  - Zhou D
AD  - Department of Neurology, West China Hospital, Sichuan University, Chengdu, 
      Sichuan Province, China. Electronic address: zhoudong66@yahoo.de.
FAU - Li, Jin-Mei
AU  - Li JM
AD  - Department of Neurology, West China Hospital, Sichuan University, Chengdu, 
      Sichuan Province, China. Electronic address: jinmeili-neuro@qq.com.
LA  - eng
PT  - Journal Article
PT  - Review
PT  - Systematic Review
DEP - 20170119
PL  - United States
TA  - Epilepsy Behav
JT  - Epilepsy & behavior : E&B
JID - 100892858
RN  - 0 (Adrenal Cortex Hormones)
RN  - 0 (Immunoglobulins, Intravenous)
RN  - 0 (Receptors, N-Methyl-D-Aspartate)
SB  - IM
MH  - Adolescent
MH  - Adrenal Cortex Hormones/therapeutic use
MH  - Adult
MH  - Anti-N-Methyl-D-Aspartate Receptor Encephalitis/complications/*diagnosis/drug 
      therapy
MH  - China
MH  - Combined Modality Therapy
MH  - Female
MH  - Humans
MH  - Immunoglobulins, Intravenous/therapeutic use
MH  - Male
MH  - Receptors, N-Methyl-D-Aspartate/*immunology
MH  - Seizures/*etiology
MH  - Young Adult
OTO - NOTNLM
OT  - Anti-N-methyl-d-aspartate receptor encephalitis
OT  - Clinical characteristics
OT  - Outcomes
OT  - Systematic review
OT  - Treatments
EDAT- 2017/01/23 06:00
MHDA- 2017/08/16 06:00
CRDT- 2017/01/23 06:00
PHST- 2016/10/23 00:00 [received]
PHST- 2016/11/20 00:00 [revised]
PHST- 2016/12/17 00:00 [accepted]
PHST- 2017/01/23 06:00 [pubmed]
PHST- 2017/08/16 06:00 [medline]
PHST- 2017/01/23 06:00 [entrez]
AID - S1525-5050(16)30608-4 [pii]
AID - 10.1016/j.yebeh.2016.12.019 [doi]
PST - ppublish
SO  - Epilepsy Behav. 2017 Mar;68:57-65. doi: 10.1016/j.yebeh.2016.12.019. Epub 2017 
      Jan 19.