PMID- 28110695
OWN - NLM
STAT- MEDLINE
DCOM- 20170724
LR  - 20191210
IS  - 1532-2777 (Electronic)
IS  - 0306-9877 (Linking)
VI  - 99
DP  - 2017 Feb
TI  - MEN1 and microRNAs: The link between sporadic pituitary, parathyroid and 
      adrenocortical tumors?
PG  - 40-44
LID - S0306-9877(16)30367-X [pii]
LID - 10.1016/j.mehy.2016.12.007 [doi]
AB  - Sporadic tumors of the pituitary, parathyroids and adrenal cortex are unique, as 
      their benign forms are very common, but malignant forms are exceptionally rare. 
      Hereditary forms of these tumors occur in multiple endocrine neoplasia syndrome 
      type 1 (MEN1). We hypothesize that the pathogenic link among the sporadic tumors 
      of these organs of different germ layers might be represented by common molecular 
      pathways involving the MEN1 gene and microRNAs (miR). miR-24 might be a microRNA 
      linking the three tumor entities, but other candidates such as miR-142-3p and 
      microRNAs forming the DLK1-MEG3 miRNA cluster might also be of importance.
CI  - Copyright (c) 2016 Elsevier Ltd. All rights reserved.
FAU - Nagy, Z
AU  - Nagy Z
AD  - 2nd Department of Medicine, Faculty of Medicine, Semmelweis University, 
      Szentkiralyi str. 46, H-1088 Budapest, Hungary.
FAU - Szabo, P M
AU  - Szabo PM
AD  - National Institutes of Health/NCI/DCTD/BRP, 9609 Medical Center Dr Bethesda MD, 
      USA.
FAU - Grolmusz, V K
AU  - Grolmusz VK
AD  - 2nd Department of Medicine, Faculty of Medicine, Semmelweis University, 
      Szentkiralyi str. 46, H-1088 Budapest, Hungary; "Lendulet-2013" Research Group, 
      Hungarian Academy of Sciences and Semmelweis University, Szentkiralyi str. 46, 
      H-1088 Budapest, Hungary.
FAU - Perge, P
AU  - Perge P
AD  - 2nd Department of Medicine, Faculty of Medicine, Semmelweis University, 
      Szentkiralyi str. 46, H-1088 Budapest, Hungary.
FAU - Igaz, I
AU  - Igaz I
AD  - Department of Gastroenterology, Szt Imre Teaching Hospital Budapest, Budapest, 
      Hungary.
FAU - Patocs, A
AU  - Patocs A
AD  - "Lendulet-2013" Research Group, Hungarian Academy of Sciences and Semmelweis 
      University, Szentkiralyi str. 46, H-1088 Budapest, Hungary; Department of 
      Laboratory Medicine, Faculty of Medicine, Semmelweis University, Szentkiralyi 
      str. 46, H-1088 Budapest, Hungary.
FAU - Igaz, P
AU  - Igaz P
AD  - 2nd Department of Medicine, Faculty of Medicine, Semmelweis University, 
      Szentkiralyi str. 46, H-1088 Budapest, Hungary. Electronic address: 
      igaz.peter@med.semmelweis-univ.hu.
LA  - eng
PT  - Journal Article
DEP - 20161219
PL  - United States
TA  - Med Hypotheses
JT  - Medical hypotheses
JID - 7505668
RN  - 0 (Calcium-Binding Proteins)
RN  - 0 (DLK1 protein, human)
RN  - 0 (Intercellular Signaling Peptides and Proteins)
RN  - 0 (MEG3 non-coding RNA, human)
RN  - 0 (MEN1 protein, human)
RN  - 0 (MIRN142 microRNA, human)
RN  - 0 (MIRN24 microRNA, human)
RN  - 0 (Membrane Proteins)
RN  - 0 (MicroRNAs)
RN  - 0 (Proto-Oncogene Proteins)
RN  - 0 (RNA, Long Noncoding)
RN  - 0 (SMAD3 protein, human)
RN  - 0 (Smad3 Protein)
RN  - 0 (Transforming Growth Factor beta)
SB  - IM
MH  - Adrenal Cortex Neoplasms/*genetics
MH  - Calcium-Binding Proteins
MH  - Cell Transformation, Neoplastic
MH  - Computational Biology/methods
MH  - Gene Expression Profiling
MH  - Humans
MH  - Intercellular Signaling Peptides and Proteins/genetics
MH  - Membrane Proteins/genetics
MH  - MicroRNAs/*genetics
MH  - Models, Theoretical
MH  - Multigene Family
MH  - Multiple Endocrine Neoplasia Type 1/*genetics
MH  - Mutation
MH  - Parathyroid Neoplasms/*genetics
MH  - Pituitary Gland/metabolism
MH  - Pituitary Neoplasms/*genetics
MH  - Proto-Oncogene Proteins/*genetics
MH  - RNA, Long Noncoding/genetics
MH  - Smad3 Protein/metabolism
MH  - Transforming Growth Factor beta/metabolism
OTO - NOTNLM
OT  - Adrenal cortex
OT  - MEN1
OT  - MicroRNA
OT  - Parathyroid
OT  - Pituitary
OT  - Tumor
EDAT- 2017/01/24 06:00
MHDA- 2017/07/25 06:00
CRDT- 2017/01/24 06:00
PHST- 2016/07/16 00:00 [received]
PHST- 2016/12/17 00:00 [accepted]
PHST- 2017/01/24 06:00 [entrez]
PHST- 2017/01/24 06:00 [pubmed]
PHST- 2017/07/25 06:00 [medline]
AID - S0306-9877(16)30367-X [pii]
AID - 10.1016/j.mehy.2016.12.007 [doi]
PST - ppublish
SO  - Med Hypotheses. 2017 Feb;99:40-44. doi: 10.1016/j.mehy.2016.12.007. Epub 2016 Dec 
      19.