PMID- 28112021
OWN - NLM
STAT- MEDLINE
DCOM- 20190514
LR  - 20190514
IS  - 1814-1412 (Electronic)
IS  - 1562-2975 (Linking)
VI  - 20
IP  - 2
DP  - 2019 Feb
TI  - Is there a role for cannabidiol in psychiatry?
PG  - 101-116
LID - 10.1080/15622975.2017.1285049 [doi]
AB  - OBJECTIVES: Understanding whether cannabidiol (CBD) is useful and safe for the 
      treatment of psychiatric disorders is essential to empower psychiatrists and 
      patients to take good clinical decisions. Our aim was to conduct a systematic 
      review regarding the benefits and adverse events (AEs) of CBD in the treatment of 
      schizophrenia, psychotic disorders, anxiety disorders, depression, bipolar 
      disorder and substance-use disorders. METHODS: We conducted a literature search 
      in PubMed, Scielo, and Clinicaltrials.gov databases. Evidence was classified 
      according to the WFSBP task forces standards. RESULTS: Bibliographic research 
      yielded 692 records. After analysis, we included six case reports and seven 
      trials, comprising 201 subjects. Most the studies published presented several 
      drawbacks and did not reach statistical significance. We have not found evidence 
      regarding major depressive and bipolar disorders. The level of evidence for 
      cannabis withdrawal is B; cannabis addiction is C2; treatment of positive 
      symptoms in schizophrenia and anxiety in social anxiety disorder is C1. Discrete 
      or no AEs were reported. The most frequently reported AEs are sedation and 
      dizziness. CONCLUSIONS: The evidence regarding efficacy and safety of CBD in 
      psychiatry is still scarce. Further larger well-designed randomised controlled 
      trials are required to assess the effects of CBD in psychiatric disorders.
FAU - Khoury, Julia Machado
AU  - Khoury JM
AUID- ORCID: 0000-0001-8842-4972
AD  - a Department of Mental Health , Federal University of Minas Gerais (UFMG) , Belo 
      Horizonte , MG , Brazil.
AD  - b Postgraduation Program in Molecular Medicine , School of Medicine, Universidade 
      Federal de Minas Gerais (UFMG) , Belo Horizonte , MG , Brazil.
FAU - Neves, Maila de Castro Lourenco das
AU  - Neves MCLD
AUID- ORCID: 0000-0003-4125-3736
AD  - a Department of Mental Health , Federal University of Minas Gerais (UFMG) , Belo 
      Horizonte , MG , Brazil.
FAU - Roque, Marco Antonio Valente
AU  - Roque MAV
AUID- ORCID: 0000-0003-2282-5647
AD  - a Department of Mental Health , Federal University of Minas Gerais (UFMG) , Belo 
      Horizonte , MG , Brazil.
FAU - Queiroz, Daniela Alves de Brito
AU  - Queiroz DAB
AUID- ORCID: 0000-0003-3671-397X
AD  - a Department of Mental Health , Federal University of Minas Gerais (UFMG) , Belo 
      Horizonte , MG , Brazil.
FAU - Correa de Freitas, Andre Augusto
AU  - Correa de Freitas AA
AUID- ORCID: 0000-0001-9907-3645
AD  - a Department of Mental Health , Federal University of Minas Gerais (UFMG) , Belo 
      Horizonte , MG , Brazil.
FAU - de Fatima, Angelo
AU  - de Fatima A
AUID- ORCID: 0000-0003-2344-5590
AD  - c Department of Chemistry , Universidade Federal de Minas Gerais (UFMG) , Belo 
      Horizonte , MG , Brazil.
FAU - Moreira, Fabricio A
AU  - Moreira FA
AUID- ORCID: 0000-0002-0824-7302
AD  - d Department of Pharmacology, Institute of Biological Sciences , Universidade 
      Federal de Minas Gerais (UFMG) , Belo Horizonte , MG , Brazil.
FAU - Garcia, Frederico Duarte
AU  - Garcia FD
AUID- ORCID: 0000-0003-1926-9053
AD  - a Department of Mental Health , Federal University of Minas Gerais (UFMG) , Belo 
      Horizonte , MG , Brazil.
AD  - b Postgraduation Program in Molecular Medicine , School of Medicine, Universidade 
      Federal de Minas Gerais (UFMG) , Belo Horizonte , MG , Brazil.
AD  - e INCT de Medicina Molecular, Universidade Federal de Minas Gerais (UFMG) , Belo 
      Horizonte , MG , Brazil.
AD  - f Unite Inserm U1073 , Rouen , France.
LA  - eng
PT  - Journal Article
PT  - Systematic Review
DEP - 20170220
PL  - England
TA  - World J Biol Psychiatry
JT  - The world journal of biological psychiatry : the official journal of the World 
      Federation of Societies of Biological Psychiatry
JID - 101120023
RN  - 19GBJ60SN5 (Cannabidiol)
SB  - IM
MH  - Cannabidiol/adverse effects/*pharmacology/*therapeutic use
MH  - Humans
MH  - Mental Disorders/*drug therapy
OTO - NOTNLM
OT  - Cannabidiol
OT  - adverse effects
OT  - pharmacotherapy
OT  - psychiatric disorders
OT  - psychiatry
EDAT- 2017/01/24 06:00
MHDA- 2019/05/15 06:00
CRDT- 2017/01/24 06:00
PHST- 2017/01/24 06:00 [pubmed]
PHST- 2019/05/15 06:00 [medline]
PHST- 2017/01/24 06:00 [entrez]
AID - 10.1080/15622975.2017.1285049 [doi]
PST - ppublish
SO  - World J Biol Psychiatry. 2019 Feb;20(2):101-116. doi: 
      10.1080/15622975.2017.1285049. Epub 2017 Feb 20.