PMID- 28112980 OWN - NLM STAT- MEDLINE DCOM- 20180109 LR - 20180130 IS - 1362-301X (Electronic) IS - 0269-9052 (Linking) VI - 31 IP - 3 DP - 2017 TI - Trajectory of disability and quality-of-life in non-geriatric and geriatric survivors after severe traumatic brain injury. PG - 319-328 LID - 10.1080/02699052.2016.1255777 [doi] AB - OBJECTIVE: The objective was to investigate disability and health-related quality-of-life (HRQoL) 3, 6 and 12 months after traumatic brain injury (TBI) in non-geriatric ( 65 years). METHODS: Patients >/= 16 years who sustained a severe TBI (Abbreviated Injury Scale of the head region > 3) were included in this prospective, multi-centre study. Outcome measures were Glasgow Outcome Scale Extended (GOSE; disability), SF-12 (HRQoL). Mixed linear model analyses were performed. RESULTS: Three hundred and fifty-one patients (median age = 50 years; interquartile range (IQR) = 27-67) were included; 73.2% were male and 27.6% were geriatric patients. Median GOSE at 3, 6 and 12 months was 5 (IQR = 3-7), 6 (IQR = 4-8) and 7 (IQR = 5-8); this increase (slope(time) = 0.22, p < 0.0001) was age dependent (slope(age*time) = -0.06, p = 0.003). Median SF-12 physical component scale score at 3, 6 and 12 months was 42.1 (IQR = 33.6-50.7), 46.6 (IQR = 37.4-53.9) and 50.4 (IQR = 39.2-55.1); this increase (slope(time) = 1.52, p < 0.0001) was not age dependent (slope(age*time) = -0.30, p = 0.083). SF-12 mental component scale scores were unchanged. CONCLUSIONS: Disability decreased and HRQoL improved after TBI between 3-12 months. In geriatric patients this improvement was relevant for HRQoL only. FAU - Haller, Chiara S AU - Haller CS AD - a Department of Psychology , Harvard University, Cambridge , Boston , MA , USA. AD - b Division of Public Psychiatry , Massachusetts Mental Health Center , Boston , MA , USA. FAU - Delhumeau, Cecile AU - Delhumeau C AD - c Division of Anaesthesiology , University Hospitals of Geneva (HUG) , Geneva , Switzerland. FAU - De Pretto, Michael AU - De Pretto M AD - c Division of Anaesthesiology , University Hospitals of Geneva (HUG) , Geneva , Switzerland. FAU - Schumacher, Rahel AU - Schumacher R AD - d Division of Cognitive and Restorative Neurology, Department of Neurology , Inselspital, Bern University Hospital, and University of Bern , Bern , Switzerland. FAU - Pielmaier, Laura AU - Pielmaier L AD - e Psychiatric Service Aargau , Windisch , Switzerland. FAU - Rebetez, Marie My Lien AU - Rebetez MM AD - f Department of Clinical Psychology , University of Geneva , Geneva , Switzerland. FAU - Haller, Guy AU - Haller G AD - c Division of Anaesthesiology , University Hospitals of Geneva (HUG) , Geneva , Switzerland. AD - g Division of Clinical Epidemiology , University Hospitals of Geneva (HUG) , Geneva , Switzerland. FAU - Walder, Bernhard AU - Walder B AD - c Division of Anaesthesiology , University Hospitals of Geneva (HUG) , Geneva , Switzerland. LA - eng PT - Journal Article PT - Multicenter Study PT - Research Support, Non-U.S. Gov't DEP - 20170123 PL - England TA - Brain Inj JT - Brain injury JID - 8710358 SB - IM MH - Adult MH - Aged MH - Aged, 80 and over MH - Aging/*psychology MH - *Brain Injuries, Traumatic/mortality/physiopathology/psychology MH - Cohort Studies MH - Disabled Persons/*psychology MH - Female MH - Glasgow Outcome Scale MH - Humans MH - Male MH - Middle Aged MH - Quality of Life/*psychology MH - Time Factors MH - Young Adult OTO - NOTNLM OT - Head injury OT - elderly OT - functional outcome OT - health-related quality-of-life OT - recovery EDAT- 2017/01/24 06:00 MHDA- 2018/01/10 06:00 CRDT- 2017/01/24 06:00 PHST- 2017/01/24 06:00 [pubmed] PHST- 2018/01/10 06:00 [medline] PHST- 2017/01/24 06:00 [entrez] AID - 10.1080/02699052.2016.1255777 [doi] PST - ppublish SO - Brain Inj. 2017;31(3):319-328. doi: 10.1080/02699052.2016.1255777. Epub 2017 Jan 23.