PMID- 28113518
OWN - NLM
STAT- MEDLINE
DCOM- 20171025
LR  - 20191210
IS  - 1940-9990 (Electronic)
IS  - 1932-4545 (Linking)
VI  - 11
IP  - 1
DP  - 2017 Feb
TI  - Optogenetics in Silicon: A Neural Processor for Predicting Optically Active 
      Neural Networks.
PG  - 15-27
LID - 10.1109/TBCAS.2016.2571339 [doi]
AB  - We present a reconfigurable neural processor for real-time simulation and 
      prediction of opto-neural behaviour. We combined a detailed Hodgkin-Huxley CA3 
      neuron integrated with a four-state Channelrhodopsin-2 (ChR2) model into 
      reconfigurable silicon hardware. Our architecture consists of a Field 
      Programmable Gated Array (FPGA) with a custom-built computing data-path, a 
      separate data management system and a memory approach based router. Advancements 
      over previous work include the incorporation of short and long-term calcium and 
      light-dependent ion channels in reconfigurable hardware. Also, the developed 
      processor is computationally efficient, requiring only 0.03 ms processing time 
      per sub-frame for a single neuron and 9.7 ms for a fully connected network of 500 
      neurons with a given FPGA frequency of 56.7 MHz. It can therefore be utilized for 
      exploration of closed loop processing and tuning of biologically realistic 
      optogenetic circuitry.
FAU - Junwen Luo
AU  - Junwen Luo
FAU - Nikolic, Konstantin
AU  - Nikolic K
FAU - Evans, Benjamin D
AU  - Evans BD
FAU - Na Dong
AU  - Na Dong
FAU - Xiaohan Sun
AU  - Xiaohan Sun
FAU - Andras, Peter
AU  - Andras P
FAU - Yakovlev, Alex
AU  - Yakovlev A
FAU - Degenaar, Patrick
AU  - Degenaar P
LA  - eng
GR  - BB/L018268/1/Biotechnology and Biological Sciences Research Council/United 
      Kingdom
PT  - Journal Article
DEP - 20160817
PL  - United States
TA  - IEEE Trans Biomed Circuits Syst
JT  - IEEE transactions on biomedical circuits and systems
JID - 101312520
RN  - 0 (Ion Channels)
RN  - Z4152N8IUI (Silicon)
SB  - IM
MH  - Ion Channels/*chemistry
MH  - *Models, Neurological
MH  - *Neural Networks, Computer
MH  - *Optogenetics
MH  - *Silicon
EDAT- 2017/01/24 06:00
MHDA- 2017/10/27 06:00
CRDT- 2017/01/24 06:00
PHST- 2017/01/24 06:00 [pubmed]
PHST- 2017/10/27 06:00 [medline]
PHST- 2017/01/24 06:00 [entrez]
AID - 10.1109/TBCAS.2016.2571339 [doi]
PST - ppublish
SO  - IEEE Trans Biomed Circuits Syst. 2017 Feb;11(1):15-27. doi: 
      10.1109/TBCAS.2016.2571339. Epub 2016 Aug 17.