PMID- 28115097
OWN - NLM
STAT- MEDLINE
DCOM- 20180709
LR  - 20181202
IS  - 1879-1344 (Electronic)
IS  - 0144-8617 (Linking)
VI  - 160
DP  - 2017 Mar 15
TI  - Development of a nanoparticle system based on a fructose polymer: Stability and 
      drug release studies.
PG  - 26-33
LID - S0144-8617(16)31394-7 [pii]
LID - 10.1016/j.carbpol.2016.12.025 [doi]
AB  - New drug delivery systems (DDSs) with levan or its carboxymethylated form, as 
      carriers, and 5-fluorouracil as a drug, are produced in this work. Levan is 
      obtained after cultivating A. nectaris and polymer nanoparticles are created in 
      water by a self-assembled process. The effect of pH and the ionic strength on 
      polymer nanoparticles aggregation is studied. Basic pHs produces a particle size 
      between 300 and 400nm with a Z-potential around -20mV because a basic medium 
      promotes repulsion forces. DDSs of 300-400nm and a Z-potential about -25mV are 
      prepared by taking advantage of the amphiphilic properties of the levan. The drug 
      is bound to either levan or carboxymethyllevan surfaces by electrostatic 
      interactions, obtaining the best results at basic pHs. 45-70% of the drug is 
      released from the levan in 23h depending on the pH preparation, whereas only a 
      low percentage of the drug is released from the carboxymethyllevan.
CI  - Copyright (c) 2016 Elsevier Ltd. All rights reserved.
FAU - Tabernero, Antonio
AU  - Tabernero A
AD  - Department of Chemical Engineering, University of Salamanca, Plaza Los Caidos 
      s/n, 37008 Salamanca, Spain.
FAU - Gonzalez-Garcinuno, Alvaro
AU  - Gonzalez-Garcinuno A
AD  - Department of Chemical Engineering, University of Salamanca, Plaza Los Caidos 
      s/n, 37008 Salamanca, Spain.
FAU - Sanchez-Alvarez, Jose M feminine
AU  - Sanchez-Alvarez JM
AD  - Department of Chemical Engineering, University of Salamanca, Plaza Los Caidos 
      s/n, 37008 Salamanca, Spain.
FAU - Galan, Miguel A
AU  - Galan MA
AD  - Department of Chemical Engineering, University of Salamanca, Plaza Los Caidos 
      s/n, 37008 Salamanca, Spain.
FAU - Martin Del Valle, Eva M
AU  - Martin Del Valle EM
AD  - Department of Chemical Engineering, University of Salamanca, Plaza Los Caidos 
      s/n, 37008 Salamanca, Spain. Electronic address: emvalle@usal.es.
LA  - eng
PT  - Journal Article
DEP - 20161209
PL  - England
TA  - Carbohydr Polym
JT  - Carbohydrate polymers
JID - 8307156
RN  - 0 (Drug Carriers)
RN  - 0 (Fructans)
RN  - 0 (Polymers)
RN  - 30237-26-4 (Fructose)
RN  - 9013-95-0 (levan)
RN  - U3P01618RT (Fluorouracil)
SB  - IM
MH  - Drug Carriers
MH  - *Drug Delivery Systems
MH  - Drug Liberation
MH  - Drug Stability
MH  - Fluorouracil/*chemistry
MH  - Fructans/*chemistry
MH  - Fructose/*chemistry
MH  - *Nanoparticles
MH  - Particle Size
MH  - Polymers
OTO - NOTNLM
OT  - 5-Fluorouracil
OT  - Carboxymethyllevan
OT  - Levan
EDAT- 2017/01/25 06:00
MHDA- 2018/07/10 06:00
CRDT- 2017/01/25 06:00
PHST- 2016/10/10 00:00 [received]
PHST- 2016/12/05 00:00 [revised]
PHST- 2016/12/08 00:00 [accepted]
PHST- 2017/01/25 06:00 [entrez]
PHST- 2017/01/25 06:00 [pubmed]
PHST- 2018/07/10 06:00 [medline]
AID - S0144-8617(16)31394-7 [pii]
AID - 10.1016/j.carbpol.2016.12.025 [doi]
PST - ppublish
SO  - Carbohydr Polym. 2017 Mar 15;160:26-33. doi: 10.1016/j.carbpol.2016.12.025. Epub 
      2016 Dec 9.