PMID- 28115102
OWN - NLM
STAT- MEDLINE
DCOM- 20180709
LR  - 20181202
IS  - 1879-1344 (Electronic)
IS  - 0144-8617 (Linking)
VI  - 160
DP  - 2017 Mar 15
TI  - Non-anticoagulant effects of low molecular weight heparins in inflammatory 
      disorders: A review.
PG  - 71-81
LID - S0144-8617(16)31415-1 [pii]
LID - 10.1016/j.carbpol.2016.12.037 [doi]
AB  - Low molecular weight heparins (LMWHs) are produced by chemical or enzymatic 
      depolymerization of unfractionated heparin (UFH). Besides their well-known 
      anticoagulant effects, LMWHs have also been reported to exhibit numerous 
      anti-inflammatory properties. Previous studies have, however, shown that 
      different production processes result in unique structural characteristics of 
      LMWHs. The structural variations may help explain the different therapeutic 
      spectrums in disease treatment for non-anticoagulant effects. In the present 
      review, we summarize major advances in understanding and exploiting the 
      anti-inflammatory disorder activities of LMWHs, based on mechanistic studies, 
      preclinical experiments and clinical trials. We highlight differences in these 
      activities of commercially available LMWHs produced using different manufacturing 
      processes. We stress the importance of structure-activity relationship (SAR) 
      studies on the non-anticoagulant effects of LMWHs and discuss strategies for 
      exploring new clinical indications.
CI  - Copyright (c) 2016 Elsevier Ltd. All rights reserved.
FAU - Yan, Yishu
AU  - Yan Y
AD  - Key Laboratory for Industrial Biocatalysis, Ministry of Education, Institute of 
      Biochemical Engineering, Department of Chemical Engineering, Centre for Synthetic 
      and Systems Biology, Tsinghua University, Room 607, Yingshi Building, Beijing 
      100084, China. Electronic address: yanyishu@sina.com.
FAU - Ji, Yang
AU  - Ji Y
AD  - Key Laboratory for Industrial Biocatalysis, Ministry of Education, Institute of 
      Biochemical Engineering, Department of Chemical Engineering, Centre for Synthetic 
      and Systems Biology, Tsinghua University, Room 607, Yingshi Building, Beijing 
      100084, China. Electronic address: jiyang0326@163.com.
FAU - Su, Nan
AU  - Su N
AD  - Key Laboratory for Industrial Biocatalysis, Ministry of Education, Institute of 
      Biochemical Engineering, Department of Chemical Engineering, Centre for Synthetic 
      and Systems Biology, Tsinghua University, Room 607, Yingshi Building, Beijing 
      100084, China. Electronic address: sunan12345@126.com.
FAU - Mei, Xiang
AU  - Mei X
AD  - Key Laboratory for Industrial Biocatalysis, Ministry of Education, Institute of 
      Biochemical Engineering, Department of Chemical Engineering, Centre for Synthetic 
      and Systems Biology, Tsinghua University, Room 607, Yingshi Building, Beijing 
      100084, China.
FAU - Wang, Yi
AU  - Wang Y
AD  - Key Laboratory for Industrial Biocatalysis, Ministry of Education, Institute of 
      Biochemical Engineering, Department of Chemical Engineering, Centre for Synthetic 
      and Systems Biology, Tsinghua University, Room 607, Yingshi Building, Beijing 
      100084, China. Electronic address: wangyi671@hotmail.com.
FAU - Du, Shanshan
AU  - Du S
AD  - Key Laboratory for Industrial Biocatalysis, Ministry of Education, Institute of 
      Biochemical Engineering, Department of Chemical Engineering, Centre for Synthetic 
      and Systems Biology, Tsinghua University, Room 607, Yingshi Building, Beijing 
      100084, China. Electronic address: shanshandu000@163.com.
FAU - Zhu, Wenming
AU  - Zhu W
AD  - Key Laboratory for Industrial Biocatalysis, Ministry of Education, Institute of 
      Biochemical Engineering, Department of Chemical Engineering, Centre for Synthetic 
      and Systems Biology, Tsinghua University, Room 607, Yingshi Building, Beijing 
      100084, China. Electronic address: piggychina@163.com.
FAU - Zhang, Chong
AU  - Zhang C
AD  - Key Laboratory for Industrial Biocatalysis, Ministry of Education, Institute of 
      Biochemical Engineering, Department of Chemical Engineering, Centre for Synthetic 
      and Systems Biology, Tsinghua University, Room 607, Yingshi Building, Beijing 
      100084, China. Electronic address: chongzhang@mail.tsinghua.edu.cn.
FAU - Lu, Yuan
AU  - Lu Y
AD  - Key Laboratory for Industrial Biocatalysis, Ministry of Education, Institute of 
      Biochemical Engineering, Department of Chemical Engineering, Centre for Synthetic 
      and Systems Biology, Tsinghua University, Room 607, Yingshi Building, Beijing 
      100084, China. Electronic address: yuanlu@tsinghua.edu.cn.
FAU - Xing, Xin-Hui
AU  - Xing XH
AD  - Key Laboratory for Industrial Biocatalysis, Ministry of Education, Institute of 
      Biochemical Engineering, Department of Chemical Engineering, Centre for Synthetic 
      and Systems Biology, Tsinghua University, Room 607, Yingshi Building, Beijing 
      100084, China. Electronic address: xhxing@tsinghua.edu.cn.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20161221
PL  - England
TA  - Carbohydr Polym
JT  - Carbohydrate polymers
JID - 8307156
RN  - 0 (Anticoagulants)
RN  - 0 (Heparin, Low-Molecular-Weight)
SB  - IM
MH  - Anticoagulants/*pharmacology
MH  - Heparin, Low-Molecular-Weight/*pharmacology
MH  - Inflammation/*drug therapy
OTO - NOTNLM
OT  - Heparin
OT  - Inflammation
OT  - Low molecular weight heparins
OT  - Non-anticoagulant
EDAT- 2017/01/25 06:00
MHDA- 2018/07/10 06:00
CRDT- 2017/01/25 06:00
PHST- 2016/09/06 00:00 [received]
PHST- 2016/11/30 00:00 [revised]
PHST- 2016/12/18 00:00 [accepted]
PHST- 2017/01/25 06:00 [entrez]
PHST- 2017/01/25 06:00 [pubmed]
PHST- 2018/07/10 06:00 [medline]
AID - S0144-8617(16)31415-1 [pii]
AID - 10.1016/j.carbpol.2016.12.037 [doi]
PST - ppublish
SO  - Carbohydr Polym. 2017 Mar 15;160:71-81. doi: 10.1016/j.carbpol.2016.12.037. Epub 
      2016 Dec 21.