PMID- 28115791
OWN - NLM
STAT- MEDLINE
DCOM- 20170221
LR  - 20220310
IS  - 1875-8630 (Electronic)
IS  - 0278-0240 (Print)
IS  - 0278-0240 (Linking)
VI  - 2016
DP  - 2016
TI  - ACE Gene I/D Polymorphism and Obesity in 1,574 Patients with Type 2 Diabetes 
      Mellitus.
PG  - 7420540
LID - 10.1155/2016/7420540 [doi]
LID - 7420540
AB  - Association between ACE gene I/D polymorphism and the risk of overweight/obesity 
      remains controversial. We investigated the possible relationship between ACE gene 
      I/D polymorphism and obesity in Chinese type 2 diabetes mellitus (T2DM) patients. 
      In this study, obesity was defined as a body mass index (BMI) value >/= 25 kg/m(2) 
      and subjects were classified into 4 groups (lean, normal, overweight, and obese). 
      PCR (polymerase chain reaction) was used to detect the ACE gene I/D polymorphism 
      in T2DM patients. Metabolic measurements including blood glucose, lipid profile, 
      and blood pressure were obtained. Frequencies of the ACE genotypes (DD, ID, and 
      II) were not significant among the 4 groups of BMI-defined patients (P = 0.679) 
      while ACE II carriers showed higher systolic blood pressure (SBP) and pulse 
      pressure (PP) (all P < 0.050). Hyperglycemia, hypertension, and dyslipidemia in 
      these T2DM patients were found to be significantly associated with BMI. In 
      conclusion, the relationship of ACE gene I/D polymorphism with obesity is 
      insignificant in Chinese patients with T2DM. SBP and PP might be higher in the 
      ACE II carriers than in the DD and ID carriers.
FAU - Pan, Yan-Hong
AU  - Pan YH
AUID- ORCID: 0000-0002-7825-2334
AD  - Center for Diabetic Systems Medicine, Guangxi Key Laboratory of Excellence, 
      Guilin Medical University, Guilin 541004, China; Institute of Basic Medical 
      Sciences, Guilin Medical University, Guilin 541004, China; Department of 
      Immunology, Faculty of Basic Medicine, Guilin Medical University, Guilin 541004, 
      China.
FAU - Wang, Min
AU  - Wang M
AD  - Center for Diabetic Systems Medicine, Guangxi Key Laboratory of Excellence, 
      Guilin Medical University, Guilin 541004, China; Institute of Basic Medical 
      Sciences, Guilin Medical University, Guilin 541004, China.
FAU - Huang, Yan-Mei
AU  - Huang YM
AD  - Center for Diabetic Systems Medicine, Guangxi Key Laboratory of Excellence, 
      Guilin Medical University, Guilin 541004, China; Institute of Basic Medical 
      Sciences, Guilin Medical University, Guilin 541004, China; Department of 
      Immunology, Faculty of Basic Medicine, Guilin Medical University, Guilin 541004, 
      China.
FAU - Wang, Ying-Hui
AU  - Wang YH
AD  - Center for Diabetic Systems Medicine, Guangxi Key Laboratory of Excellence, 
      Guilin Medical University, Guilin 541004, China; Institute of Basic Medical 
      Sciences, Guilin Medical University, Guilin 541004, China; Department of 
      Immunology, Faculty of Basic Medicine, Guilin Medical University, Guilin 541004, 
      China.
FAU - Chen, Yin-Ling
AU  - Chen YL
AD  - Center for Diabetic Systems Medicine, Guangxi Key Laboratory of Excellence, 
      Guilin Medical University, Guilin 541004, China; Institute of Basic Medical 
      Sciences, Guilin Medical University, Guilin 541004, China; Department of 
      Immunology, Faculty of Basic Medicine, Guilin Medical University, Guilin 541004, 
      China.
FAU - Geng, Li-Jun
AU  - Geng LJ
AD  - Center for Diabetic Systems Medicine, Guangxi Key Laboratory of Excellence, 
      Guilin Medical University, Guilin 541004, China; Institute of Basic Medical 
      Sciences, Guilin Medical University, Guilin 541004, China; Department of 
      Immunology, Faculty of Basic Medicine, Guilin Medical University, Guilin 541004, 
      China.
FAU - Zhang, Xiao-Xi
AU  - Zhang XX
AUID- ORCID: 0000-0001-8406-4113
AD  - Center for Diabetic Systems Medicine, Guangxi Key Laboratory of Excellence, 
      Guilin Medical University, Guilin 541004, China; Institute of Basic Medical 
      Sciences, Guilin Medical University, Guilin 541004, China.
FAU - Zhao, Hai-Lu
AU  - Zhao HL
AUID- ORCID: 0000-0001-6670-3604
AD  - Center for Diabetic Systems Medicine, Guangxi Key Laboratory of Excellence, 
      Guilin Medical University, Guilin 541004, China; Institute of Basic Medical 
      Sciences, Guilin Medical University, Guilin 541004, China; Department of 
      Immunology, Faculty of Basic Medicine, Guilin Medical University, Guilin 541004, 
      China.
LA  - eng
PT  - Comparative Study
PT  - Journal Article
DEP - 20161226
PL  - United States
TA  - Dis Markers
JT  - Disease markers
JID - 8604127
RN  - 0 (Biomarkers)
RN  - 0 (Blood Glucose)
RN  - EC 3.4.15.1 (ACE protein, human)
RN  - EC 3.4.15.1 (Peptidyl-Dipeptidase A)
SB  - IM
MH  - Biomarkers/*metabolism
MH  - Blood Glucose/analysis
MH  - Cross-Sectional Studies
MH  - Diabetes Mellitus, Type 2/*epidemiology/etiology
MH  - Female
MH  - Follow-Up Studies
MH  - Genetic Predisposition to Disease
MH  - Genotype
MH  - Humans
MH  - Hypertension/complications/genetics
MH  - Male
MH  - Middle Aged
MH  - Obesity/complications/*genetics
MH  - Overweight/complications/*genetics
MH  - Peptidyl-Dipeptidase A/*genetics
MH  - Polymorphism, Genetic/*genetics
MH  - Prognosis
MH  - Thinness/complications/*genetics
PMC - PMC5220452
COIS- The authors declare that no competing interests exist.
EDAT- 2017/01/25 06:00
MHDA- 2017/02/22 06:00
PMCR- 2016/12/26
CRDT- 2017/01/25 06:00
PHST- 2016/08/18 00:00 [received]
PHST- 2016/11/14 00:00 [revised]
PHST- 2016/12/04 00:00 [accepted]
PHST- 2017/01/25 06:00 [entrez]
PHST- 2017/01/25 06:00 [pubmed]
PHST- 2017/02/22 06:00 [medline]
PHST- 2016/12/26 00:00 [pmc-release]
AID - 10.1155/2016/7420540 [doi]
PST - ppublish
SO  - Dis Markers. 2016;2016:7420540. doi: 10.1155/2016/7420540. Epub 2016 Dec 26.