PMID- 28115959
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20201001
IS  - 1689-832X (Print)
IS  - 2081-2841 (Electronic)
IS  - 2081-2841 (Linking)
VI  - 8
IP  - 6
DP  - 2016 Dec
TI  - Model assessment of individual tumor control rate and adverse effects in 
      comparing locally advanced cervical cancer treatment using intracavitary with and 
      without interstitial brachytherapy.
PG  - 525-532
LID - 10.5114/jcb.2016.64743 [doi]
AB  - PURPOSE: This study assessed the modeled probability of tumor control and organ 
      at risk toxicities in locally advanced cervical cancer in patients treated by 
      external beam radiation plus brachytherapy using intracavitary combined with 
      interstitial brachytherapy (IC/IS) vs. intracavitary brachytherapy (IC) alone. 
      MATERIAL AND METHODS: Twenty cervical cancer patients with a mean HR-CTV volume 
      of 47.4 cm(3) and a mean width of 54 mm were planned with both IC/IS and IC 
      brachytherapy alone. A probit model was utilized to model 3-year (3-yr) local 
      control rate (LC), 3-yr cancer specific survival rate (CSS), and the adverse 
      effect (AE) of the organ at risk by using a modeled data set from multiple 
      institutions. Modeling results were used to estimate the LC, CSS, and AE of the 
      treatments in this study. RESULTS: Using the IC/IS technique, an EQD(2) increase 
      of 12.3 Gy to D(90) (from 76.1 Gy to 88.3 Gy) of HR-CTV is expected to increase 
      3-yr LC and 3-yr CSS by 12.5%, and 11.0%, respectively. Comparing IC/IS to IC 
      alone, the expected G2(+) AE were 7.7% vs. 7.9% for the bladder, and 5.9% vs. 
      6.8% for the rectum. CONCLUSIONS: The IC/IS technique improved dose coverage to 
      the HR-CTV without significantly increasing dose to 2 cm(3) of the organ at risk 
      (OAR) surrounding it. With different regimens of EBRT combined with BT, IC/IS can 
      be used to increase the probability of LC and CSS, or decrease the risk of AE.
FAU - Kuo, Hsiang-Chi
AU  - Kuo HC
AD  - Department of Radiation Oncology, Montefiore Medical Center, New York; Albert 
      Einstein College of Medicine, New York.
FAU - Mehta, Keyur J
AU  - Mehta KJ
AD  - Department of Radiation Oncology, Montefiore Medical Center, New York; Albert 
      Einstein College of Medicine, New York.
FAU - Yaparpalvi, Ravindra
AU  - Yaparpalvi R
AD  - Department of Radiation Oncology, Montefiore Medical Center, New York; Albert 
      Einstein College of Medicine, New York.
FAU - Shankar, Viswanathan
AU  - Shankar V
AD  - Albert Einstein College of Medicine, New York; Department of Epidemiology and 
      Population Health, New York, USA.
FAU - Bodner, William
AU  - Bodner W
AD  - Department of Radiation Oncology, Montefiore Medical Center, New York; Albert 
      Einstein College of Medicine, New York.
FAU - Garg, Madhur
AU  - Garg M
AD  - Department of Radiation Oncology, Montefiore Medical Center, New York; Albert 
      Einstein College of Medicine, New York.
FAU - Rivera, Amanda
AU  - Rivera A
AD  - Department of Radiation Oncology, Montefiore Medical Center, New York.
FAU - Tome, Wolfgang A
AU  - Tome WA
AD  - Department of Radiation Oncology, Montefiore Medical Center, New York; Albert 
      Einstein College of Medicine, New York.
FAU - Kalnicki, Shalom
AU  - Kalnicki S
AD  - Department of Radiation Oncology, Montefiore Medical Center, New York; Albert 
      Einstein College of Medicine, New York.
LA  - eng
PT  - Journal Article
DEP - 20161220
PL  - Poland
TA  - J Contemp Brachytherapy
JT  - Journal of contemporary brachytherapy
JID - 101506276
PMC - PMC5241380
OTO - NOTNLM
OT  - adverse effect
OT  - brachytherapy
OT  - cervical cancer
OT  - tumor control
EDAT- 2017/01/25 06:00
MHDA- 2017/01/25 06:01
PMCR- 2016/12/01
CRDT- 2017/01/25 06:00
PHST- 2016/06/07 00:00 [received]
PHST- 2016/11/24 00:00 [accepted]
PHST- 2017/01/25 06:00 [entrez]
PHST- 2017/01/25 06:00 [pubmed]
PHST- 2017/01/25 06:01 [medline]
PHST- 2016/12/01 00:00 [pmc-release]
AID - 28945 [pii]
AID - 10.5114/jcb.2016.64743 [doi]
PST - ppublish
SO  - J Contemp Brachytherapy. 2016 Dec;8(6):525-532. doi: 10.5114/jcb.2016.64743. Epub 
      2016 Dec 20.