PMID- 28116487
OWN - NLM
STAT- MEDLINE
DCOM- 20180430
LR  - 20220310
IS  - 1615-2573 (Electronic)
IS  - 0910-8327 (Linking)
VI  - 32
IP  - 7
DP  - 2017 Jul
TI  - Interleukin-1beta is associated with coronary endothelial dysfunction in patients 
      with mTOR-inhibitor-eluting stent implantation.
PG  - 823-832
LID - 10.1007/s00380-017-0947-x [doi]
AB  - Implantation of mammalian target of rapamycin (mTOR)-inhibitor drug-eluting 
      stents (DESs) impairs coronary endothelial function. There are no known 
      non-invasive biomarkers of coronary endothelial dysfunction. We aimed to assess 
      the association between serum interleukin-1beta (IL-1beta) and coronary endothelial 
      dysfunction in patients with mTOR-inhibitor DES implantation and to investigate 
      the association between the mTOR pathway and IL-1beta. We enrolled 35 patients who 
      had implanted DESs for coronary artery disease. At a 10-month follow-up, 
      peripheral venous blood samples were collected to measure IL-1beta levels. Coronary 
      endothelial dysfunction was evaluated by intracoronary infusion of incremental 
      doses of acetylcholine. Serum IL-1beta levels were significantly associated with the 
      magnitude of vasoconstriction to acetylcholine at the segment distal (P < 0.05) 
      but not proximal to the stent. Serum IL-1beta levels were positively correlated with 
      stent length (P < 0.05). To examine the direct effects of mTOR inhibition on 
      IL-1beta release, sirolimus was incubated in cultured human umbilical vein 
      endothelial cells (HUVECs) or coronary artery smooth muscle cells (CASMCs). 
      Sirolimus directly increased IL-1beta mRNA expression (P < 0.01) and enhanced IL-1beta 
      release into the culture media (P < 0.01) in CASMCs, but not in HUVECs. 
      Inhibition of mTOR triggers IL-1beta release through transcriptional activation in 
      CASMCs. Serum IL-1beta levels are a potential biomarker for mTOR-inhibitor 
      DES-associated coronary endothelial dysfunction.
FAU - Chibana, Hidetoshi
AU  - Chibana H
AD  - Division of Cardio-Vascular Medicine, Department of Internal Medicine, Kurume 
      University School of Medicine, 67 Asahi-machi, Kurume, Fukuoka, 830-0011, Japan.
FAU - Kajimoto, Hidemi
AU  - Kajimoto H
AD  - Division of Cardio-Vascular Medicine, Department of Internal Medicine, Kurume 
      University School of Medicine, 67 Asahi-machi, Kurume, Fukuoka, 830-0011, Japan. 
      kajimoto@med.kurume-u.ac.jp.
FAU - Ueno, Takafumi
AU  - Ueno T
AD  - Division of Cardio-Vascular Medicine, Department of Internal Medicine, Kurume 
      University School of Medicine, 67 Asahi-machi, Kurume, Fukuoka, 830-0011, Japan.
FAU - Yokoyama, Shinji
AU  - Yokoyama S
AD  - Division of Cardio-Vascular Medicine, Department of Internal Medicine, Kurume 
      University School of Medicine, 67 Asahi-machi, Kurume, Fukuoka, 830-0011, Japan.
FAU - Sasaki, Ken-Ichiro
AU  - Sasaki KI
AD  - Division of Cardio-Vascular Medicine, Department of Internal Medicine, Kurume 
      University School of Medicine, 67 Asahi-machi, Kurume, Fukuoka, 830-0011, Japan.
FAU - Ohtsuka, Masanori
AU  - Ohtsuka M
AD  - Division of Cardio-Vascular Medicine, Department of Internal Medicine, Kurume 
      University School of Medicine, 67 Asahi-machi, Kurume, Fukuoka, 830-0011, Japan.
FAU - Koiwaya, Hiroshi
AU  - Koiwaya H
AD  - Division of Cardio-Vascular Medicine, Department of Internal Medicine, Kurume 
      University School of Medicine, 67 Asahi-machi, Kurume, Fukuoka, 830-0011, Japan.
FAU - Nakayoshi, Takaharu
AU  - Nakayoshi T
AD  - Division of Cardio-Vascular Medicine, Department of Internal Medicine, Kurume 
      University School of Medicine, 67 Asahi-machi, Kurume, Fukuoka, 830-0011, Japan.
FAU - Mitsutake, Yoshiaki
AU  - Mitsutake Y
AD  - Division of Cardio-Vascular Medicine, Department of Internal Medicine, Kurume 
      University School of Medicine, 67 Asahi-machi, Kurume, Fukuoka, 830-0011, Japan.
FAU - Itaya, Naoki
AU  - Itaya N
AD  - Division of Cardio-Vascular Medicine, Department of Internal Medicine, Kurume 
      University School of Medicine, 67 Asahi-machi, Kurume, Fukuoka, 830-0011, Japan.
FAU - Sasaki, Masahiro
AU  - Sasaki M
AD  - Division of Cardio-Vascular Medicine, Department of Internal Medicine, Kurume 
      University School of Medicine, 67 Asahi-machi, Kurume, Fukuoka, 830-0011, Japan.
FAU - Fukumoto, Yoshihiro
AU  - Fukumoto Y
AD  - Division of Cardio-Vascular Medicine, Department of Internal Medicine, Kurume 
      University School of Medicine, 67 Asahi-machi, Kurume, Fukuoka, 830-0011, Japan.
LA  - eng
PT  - Journal Article
DEP - 20170123
PL  - Japan
TA  - Heart Vessels
JT  - Heart and vessels
JID - 8511258
RN  - 0 (Biomarkers)
RN  - 0 (IL1B protein, human)
RN  - 0 (Interleukin-1beta)
RN  - EC 2.7.11.1 (TOR Serine-Threonine Kinases)
RN  - W36ZG6FT64 (Sirolimus)
SB  - IM
MH  - Aged
MH  - Biomarkers/blood
MH  - Coronary Artery Disease/*physiopathology/therapy
MH  - Coronary Vessels/*physiopathology
MH  - Drug-Eluting Stents/*adverse effects
MH  - Endothelium, Vascular/drug effects/*pathology
MH  - Female
MH  - Humans
MH  - Interleukin-1beta/*blood
MH  - Japan
MH  - Linear Models
MH  - Male
MH  - Percutaneous Coronary Intervention
MH  - Sirolimus/pharmacology
MH  - TOR Serine-Threonine Kinases/antagonists & inhibitors
MH  - Vasoconstriction/drug effects
OTO - NOTNLM
OT  - Biomarker
OT  - Coronary artery
OT  - Drug-eluting stent
OT  - Endothelial dysfunction
EDAT- 2017/01/25 06:00
MHDA- 2018/05/01 06:00
CRDT- 2017/01/25 06:00
PHST- 2016/09/12 00:00 [received]
PHST- 2017/01/06 00:00 [accepted]
PHST- 2017/01/25 06:00 [pubmed]
PHST- 2018/05/01 06:00 [medline]
PHST- 2017/01/25 06:00 [entrez]
AID - 10.1007/s00380-017-0947-x [pii]
AID - 10.1007/s00380-017-0947-x [doi]
PST - ppublish
SO  - Heart Vessels. 2017 Jul;32(7):823-832. doi: 10.1007/s00380-017-0947-x. Epub 2017 
      Jan 23.