PMID- 28117505
OWN - NLM
STAT- MEDLINE
DCOM- 20180215
LR  - 20200613
IS  - 1097-0193 (Electronic)
IS  - 1065-9471 (Print)
IS  - 1065-9471 (Linking)
VI  - 38
IP  - 5
DP  - 2017 May
TI  - Age-associated patterns in gray matter volume, cerebral perfusion and BOLD 
      oscillations in children and adolescents.
PG  - 2398-2407
LID - 10.1002/hbm.23526 [doi]
AB  - Healthy brain development involves changes in brain structure and function that 
      are believed to support cognitive maturation. However, understanding how 
      structural changes such as grey matter thinning relate to functional changes is 
      challenging. To gain insight into structure-function relationships in 
      development, the present study took a data driven approach to define age-related 
      patterns of variation in gray matter volume (GMV), cerebral blood flow (CBF) and 
      blood-oxygen level dependent (BOLD) signal variation (fractional amplitude of 
      low-frequency fluctuations; fALFF) in 59 healthy children aged 7-18 years, and 
      examined relationships between modalities. Principal components analysis (PCA) 
      was applied to each modality in parallel, and participant scores for the top 
      components were assessed for age associations. We found that decompositions of 
      CBF, GMV and fALFF all included components for which scores were significantly 
      associated with age. The dominant patterns in GMV and CBF showed significant 
      (GMV) or trend level (CBF) associations with age and a strong spatial overlap, 
      driven by increased signal intensity in default mode network (DMN) regions. GMV, 
      CBF and fALFF additionally showed components accounting for 3-5% of variability 
      with significant age associations. However, these patterns were relatively 
      spatially independent, with small-to-moderate overlap between modalities. 
      Independence of age effects was further demonstrated by correlating individual 
      subject maps between modalities: CBF was significantly less correlated with GMV 
      and fALFF in older children relative to younger. These spatially independent 
      effects of age suggest that the parallel decline observed in global GMV and CBF 
      may not reflect spatially synchronized processes. Hum Brain Mapp 38:2398-2407, 
      2017. (c) 2017 Wiley Periodicals, Inc.
CI  - (c) 2017 Wiley Periodicals, Inc.
FAU - Bray, Signe
AU  - Bray S
AD  - Departments of Radiology and Pediatrics, Cumming School of Medicine, University 
      of Calgary, 2500 University Ave NW, Calgary AB, T2N1N4, Canada.
AD  - Child and Adolescent Imaging Research (CAIR) Program, 2888 Shaganappi Trail NW, 
      Calgary, AB, T3B 6A8, Canada.
AD  - Alberta Children's Hospital Research Institute (ACHRI), 2888 Shaganappi Trail NW, 
      Calgary, AB, T3B 6A8, Canada.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20170124
PL  - United States
TA  - Hum Brain Mapp
JT  - Human brain mapping
JID - 9419065
RN  - S88TT14065 (Oxygen)
SB  - IM
MH  - Adolescent
MH  - *Aging/blood
MH  - *Brain Mapping
MH  - Cerebrovascular Circulation/*physiology
MH  - Child
MH  - Female
MH  - Gray Matter/*physiology
MH  - Humans
MH  - Image Processing, Computer-Assisted
MH  - Magnetic Resonance Imaging
MH  - Male
MH  - *Models, Neurological
MH  - Oxygen/*blood
MH  - Principal Component Analysis
MH  - Young Adult
PMC - PMC6866757
OTO - NOTNLM
OT  - brain development
OT  - magnetic resonance imaging
OT  - multimodal
EDAT- 2017/01/25 06:00
MHDA- 2018/02/16 06:00
PMCR- 2017/01/24
CRDT- 2017/01/25 06:00
PHST- 2016/06/19 00:00 [received]
PHST- 2016/11/05 00:00 [revised]
PHST- 2016/12/13 00:00 [accepted]
PHST- 2017/01/25 06:00 [pubmed]
PHST- 2018/02/16 06:00 [medline]
PHST- 2017/01/25 06:00 [entrez]
PHST- 2017/01/24 00:00 [pmc-release]
AID - HBM23526 [pii]
AID - 10.1002/hbm.23526 [doi]
PST - ppublish
SO  - Hum Brain Mapp. 2017 May;38(5):2398-2407. doi: 10.1002/hbm.23526. Epub 2017 Jan 
      24.