PMID- 28117923
OWN - NLM
STAT- MEDLINE
DCOM- 20180522
LR  - 20181127
IS  - 1522-2586 (Electronic)
IS  - 1053-1807 (Linking)
VI  - 46
IP  - 3
DP  - 2017 Sep
TI  - Diffusion-weighted quantitative MRI of pleural abnormalities: Intra- and 
      interobserver variability in the apparent diffusion coefficient measurements.
PG  - 769-782
LID - 10.1002/jmri.25633 [doi]
AB  - PURPOSE: To assess intra- and interobserver variability in the apparent diffusion 
      coefficient (ADC) measurements of pleural abnormalities. MATERIALS AND METHODS: 
      Diffusion-weighted magnetic resonance imaging was performed in 34 patients to 
      characterize pleural abnormalities, with a 1.5T unit at b values of 0/150/500/800 
      sec/mm(2) . In two sessions held 3 months apart, on perfusion-free ADC maps, two 
      independent readers measured the ADC of pleural abnormalities (two readings for 
      each reader in each case) using different methods of region-of-interest (ROI) 
      positioning. In three methods, freehand ROIs were drawn within tumor boundaries 
      to encompass the entire lesion on one or more axial slices (whole tumor volume 
      [WTV], three slices observer-defined [TSOD], single-slice [SS]), while in two 
      methods one or more ROIs were placed on the more restricted areas (multiple small 
      round ROI [MSR], one small round ROI [OSR]). Measurement variability between 
      readings by each reader (intraobserver repeatability) and between readers in 
      first reading (interobserver repeatability) were assessed using intraclass 
      correlation coefficient (ICC) and coefficient of variation (CoV). Analysis of 
      variance (ANOVA) was performed to compare ADC values between the different 
      methods. The measurement time of each case for all methods in first reading was 
      recorded and compared between methods and readers. RESULTS: All methods 
      demonstrated good (MSR, OSR) and excellent (WTV, TSOD, SS) intra- and interreader 
      agreement, with best and worst repeatability in WTV (lower ICC, 0.977; higher 
      CoV, 3.5%) and OSR (lower ICC, 0.625; higher CoV, 22.8%), respectively. The lower 
      95% confidence interval of ICC resulted in fair to moderate agreement for OSR (up 
      to 0.379) and in excellent agreement for WTV, TSV, and SS (up to 0.918). ADC 
      values of OSR and MSR were significantly lower compared to other methods (P < 
      0.001). The OSR and SS required less measurement time (10 and 21/22 sec, 
      respectively) compared to the others (P < 0.0001), while the WTV required the 
      longest measurement time (132/134 sec) (P < 0.0001). CONCLUSION: ADC measurements 
      of pleural abnormalities are repeatable. The SS method has excellent 
      repeatability, similar to WTV, but requires significantly less measurement time. 
      Thus, its use should be preferred in clinical practice. LEVEL OF EVIDENCE: 4 
      Technical Efficacy: Stage 2 J. MAGN. RESON. IMAGING 2017;46:769-782.
CI  - (c) 2017 International Society for Magnetic Resonance in Medicine.
FAU - Priola, Adriano Massimiliano
AU  - Priola AM
AD  - Department of Diagnostic Imaging, San Luigi Gonzaga University Hospital, 
      Orbassano (Torino), Italy.
FAU - Priola, Sandro Massimo
AU  - Priola SM
AD  - Department of Diagnostic Imaging, San Luigi Gonzaga University Hospital, 
      Orbassano (Torino), Italy.
FAU - Gned, Dario
AU  - Gned D
AD  - Department of Diagnostic Imaging, San Luigi Gonzaga University Hospital, 
      Orbassano (Torino), Italy.
FAU - Giraudo, Maria Teresa
AU  - Giraudo MT
AD  - Department of Mathematics, Giuseppe Peano, University of Torino, Torino, Italy.
FAU - Brundu, Maria
AU  - Brundu M
AD  - Department of Diagnostic Imaging, San Luigi Gonzaga University Hospital, 
      Orbassano (Torino), Italy.
FAU - Righi, Luisella
AU  - Righi L
AD  - Department of Pathology, San Luigi Gonzaga University Hospital, Orbassano 
      (Torino), Italy.
FAU - Veltri, Andrea
AU  - Veltri A
AD  - Department of Diagnostic Imaging, San Luigi Gonzaga University Hospital, 
      Orbassano (Torino), Italy.
LA  - eng
PT  - Journal Article
DEP - 20170124
PL  - United States
TA  - J Magn Reson Imaging
JT  - Journal of magnetic resonance imaging : JMRI
JID - 9105850
SB  - IM
MH  - Adult
MH  - Aged
MH  - Diffusion Magnetic Resonance Imaging/*methods
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Observer Variation
MH  - Pleura/diagnostic imaging
MH  - Pleural Diseases/*diagnostic imaging
MH  - Reproducibility of Results
MH  - Retrospective Studies
MH  - Sensitivity and Specificity
OTO - NOTNLM
OT  - apparent diffusion coefficient
OT  - diffusion-weighted magnetic resonance imaging
OT  - measurement variability
OT  - pleura
OT  - region of interest
EDAT- 2017/01/25 06:00
MHDA- 2018/05/23 06:00
CRDT- 2017/01/25 06:00
PHST- 2016/10/25 00:00 [received]
PHST- 2016/12/28 00:00 [accepted]
PHST- 2017/01/25 06:00 [pubmed]
PHST- 2018/05/23 06:00 [medline]
PHST- 2017/01/25 06:00 [entrez]
AID - 10.1002/jmri.25633 [doi]
PST - ppublish
SO  - J Magn Reson Imaging. 2017 Sep;46(3):769-782. doi: 10.1002/jmri.25633. Epub 2017 
      Jan 24.