PMID- 28118064
OWN - NLM
STAT- MEDLINE
DCOM- 20170922
LR  - 20220317
IS  - 1555-8576 (Electronic)
IS  - 1538-4047 (Print)
IS  - 1538-4047 (Linking)
VI  - 18
IP  - 2
DP  - 2017 Feb
TI  - Co-expression network analysis of long noncoding RNAs (IncRNAs) and cancer genes 
      revealsSFTA1P and CASC2abnormalities in lung squamous cell carcinoma.
PG  - 115-122
LID - 10.1080/15384047.2017.1281494 [doi]
AB  - Lung squamous cell carcinoma(LSCC) is the most common and aggressive lung tumor 
      with poor clinical outcome. Previously studies showed that deregulation of long 
      noncoding RNAs (lncRNAs) were involved in LSCC. We intended to figure out the 
      role of lncRNAs in the regulation process of cancer-related genes and pathways 
      they are involved. Data of 552 samples, including 501 cancer samples and 51 
      normal ones, were extracted from The Cancer Genome Atlas (TCGA). Differentially 
      expressed lncRNAs (DEIs) were screened out (FDR<0.05, |logFC|>1) and then 
      followed by GO ontology and KEGG annotation analysis. Oncogenes from COSMIC data 
      set and Tumor suppressor genes (TSGs) from TSGene data set were collected and 
      analyzed by gene Set Enrichment Analysis (GSEA) . The differentially expressed 
      oncogenes and tumor supressor gene (TSGs) were obtained and co-expression 
      analysis was conducted to generate co-expression lncRNA-gene pairs, which can be 
      helpful in figuring out the role of lncRNA in the regulation of oncogenes and 
      tumor suppressor genes. A total of 31 lncRNAs with low expression levels and 37 
      lncRNAs with high expression levels were screened out and most of them were 
      enriched in pathways such as meiosis, male gamete generation, defensins. Of note, 
      SFTA1P and CASC2 were found to be related with most of the oncogenes and TSGs by 
      co-expression analysis. We suggested SFTA1P and CASC2 played important role in 
      the regulation of both oncogene and TSGs during the carcinogenesis of LSCC and 
      have the potential to be applied in future diagnosis, prognostic process and 
      target therapy of LSCC.
FAU - Huang, Guang-Qing
AU  - Huang GQ
AD  - a Department of Intensive Care Unit , Renmin Hospital, Hubei University of 
      Medicine , Shiyan , Hubei , P.R. China.
FAU - Ke, Zun-Ping
AU  - Ke ZP
AD  - b Department of Cardiology , The Fifth People's Hospital of Shanghai, Fudan 
      University , Shanghai , China.
FAU - Hu, Hai-Bo
AU  - Hu HB
AD  - c Department of Thoracic Surgery , The Affiliated Huai'an Hospital of Xuzhou 
      Medical University and The Second People's Hospital of Huai'an , Huai'an , China.
FAU - Gu, Biao
AU  - Gu B
AD  - d Department of Thoracic Surgery , Huai'an First People's Hospital, Nanjing 
      Medical University , Huai'an, Jiangsu , China.
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Cancer Biol Ther
JT  - Cancer biology & therapy
JID - 101137842
RN  - 0 (RNA, Long Noncoding)
RN  - 0 (Tumor Suppressor Proteins)
RN  - 0 (long non-coding RNA CASC2, human)
RN  - 0 (long non-coding RNA SFTA1P, human)
SB  - IM
MH  - Carcinoma, Non-Small-Cell Lung/*pathology
MH  - Carcinoma, Squamous Cell/pathology
MH  - Humans
MH  - Lung Neoplasms/pathology
MH  - Male
MH  - Oncogenes
MH  - Prognosis
MH  - RNA, Long Noncoding/*genetics/metabolism
MH  - Tumor Suppressor Proteins/*genetics/metabolism
PMC - PMC5362987
OTO - NOTNLM
OT  - Enrichment pathways
OT  - lncRNA
OT  - lung squamous cell carcinoma
OT  - prognostic marker
EDAT- 2017/01/25 06:00
MHDA- 2017/09/25 06:00
PMCR- 2018/01/24
CRDT- 2017/01/25 06:00
PHST- 2017/01/25 06:00 [pubmed]
PHST- 2017/09/25 06:00 [medline]
PHST- 2017/01/25 06:00 [entrez]
PHST- 2018/01/24 00:00 [pmc-release]
AID - 1281494 [pii]
AID - 10.1080/15384047.2017.1281494 [doi]
PST - ppublish
SO  - Cancer Biol Ther. 2017 Feb;18(2):115-122. doi: 10.1080/15384047.2017.1281494.