PMID- 28119119
OWN - NLM
STAT- MEDLINE
DCOM- 20171222
LR  - 20220317
IS  - 1872-7492 (Electronic)
IS  - 0168-1702 (Linking)
VI  - 232
DP  - 2017 Mar 15
TI  - Association between chronic hepatitis B virus infection and HLA-DP gene 
      polymorphisms in the Turkish population.
PG  - 6-12
LID - S0168-1702(16)30720-1 [pii]
LID - 10.1016/j.virusres.2017.01.017 [doi]
AB  - AIM: Hepatitis B virus (HBV) affects approximately 360 million people worldwide. 
      10-15% of patients with chronic HBV develop liver cirrhosis (LC), liver failure 
      and hepatocellular carcinoma (HCC). Chronic HBV infection or HBV clearance is 
      influenced by both viral and host factors. In genome-wide association studies 
      (GWAS), the human leukocyte antigen (HLA) gene polymorphisms rs3077 and rs9277535 
      were identified to be associated with chronic hepatitis B. HLA genes have been 
      linked to immune response to infectious agents. Genetic variants in HLA genes 
      influence HLA mRNA expression which might also affect antigen presentation. We 
      evaluated the association between HLA gene polymorphisms and the risk for 
      persistent HBV infection. METHODS: In the current study, HLA gene polymorphisms 
      were investigated in a case-control study of 294 chronic HBV patients and 234 
      persons with HBV natural clearance by using a real-time polymerase chain reaction 
      (RT-PCR). RESULTS: The results showed that rs9277535 allele frequency is 
      associated with HBV infection in the Turkish subjects examined (P=0.048). 
      However, no association was found for rs3077. Additionally, the AG haplotype 
      block showed a protective effect against the risk of persistent HBV infection 
      (for the rs3077A/rs9277535G, OR=0.52; 95% 0.34-0.80, P=0.003). CONCLUSIONS: Our 
      results, for the first time, demonstrate that HLA-DPB1 gene rs9277535A allele has 
      a major effect on the risk of persistent HBV infection. We suggest that further 
      independent studies are necessary to clarify the association of these 
      polymorphisms with persistence or natural clearance of HBV infection in Caucasian 
      populations.
CI  - Copyright (c) 2017 Elsevier B.V. All rights reserved.
FAU - Akgollu, Ersin
AU  - Akgollu E
AD  - Cukurova University, Faculty of Medicine, Department of Gastroenterology, Adana, 
      Turkey. Electronic address: ersin0571@gmail.com.
FAU - Bilgin, Ramazan
AU  - Bilgin R
AD  - Department of Chemistry, Arts and Science Faculty, Cukurova University, Adana, 
      Turkey. Electronic address: rbilgin@cu.edu.tr.
FAU - Akkiz, Hikmet
AU  - Akkiz H
AD  - Cukurova University, Faculty of Medicine, Department of Gastroenterology, Adana, 
      Turkey. Electronic address: hakkiz@superonline.com.
FAU - Ulger, Yakup
AU  - Ulger Y
AD  - Cukurova University, Faculty of Medicine, Department of Gastroenterology, Adana, 
      Turkey. Electronic address: yakup73us@yahoo.com.
FAU - Kaya, Berrin Yalinbas
AU  - Kaya BY
AD  - Cukurova University, Faculty of Medicine, Department of Gastroenterology, Adana, 
      Turkey. Electronic address: berrinyalinbaskaya@hotmail.com.
FAU - Karaogullarindan, Umit
AU  - Karaogullarindan U
AD  - Cukurova University, Faculty of Medicine, Department of Gastroenterology, Adana, 
      Turkey. Electronic address: umit2462@hotmail.com.
FAU - Arslan, Yusuf Kemal
AU  - Arslan YK
AD  - Cukurova University, Faculty of Medicine, Department of Biostatistics, Adana, 
      Turkey. Electronic address: ykarslan@gmail.com.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20170122
PL  - Netherlands
TA  - Virus Res
JT  - Virus research
JID - 8410979
RN  - 0 (HLA-DP beta-Chains)
RN  - 0 (HLA-DPB1 antigen)
RN  - 0 (Hepatitis B Core Antigens)
RN  - 0 (Hepatitis B Surface Antigens)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Alleles
MH  - Case-Control Studies
MH  - Female
MH  - Gene Expression
MH  - Gene Frequency
MH  - *Genetic Predisposition to Disease
MH  - Genome-Wide Association Study
MH  - HLA-DP beta-Chains/*genetics/immunology
MH  - Hepatitis B Core Antigens/genetics/immunology
MH  - Hepatitis B Surface Antigens/genetics/immunology
MH  - Hepatitis B virus/pathogenicity/physiology
MH  - Hepatitis B, Chronic/*genetics/immunology/virology
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Models, Genetic
MH  - *Polymorphism, Single Nucleotide
MH  - Real-Time Polymerase Chain Reaction
MH  - Turkey
OTO - NOTNLM
OT  - HBV clearance
OT  - HLA polymorphism
OT  - rs3077
OT  - rs9277535
EDAT- 2017/01/26 06:00
MHDA- 2017/12/23 06:00
CRDT- 2017/01/26 06:00
PHST- 2016/11/05 00:00 [received]
PHST- 2017/01/17 00:00 [revised]
PHST- 2017/01/17 00:00 [accepted]
PHST- 2017/01/26 06:00 [pubmed]
PHST- 2017/12/23 06:00 [medline]
PHST- 2017/01/26 06:00 [entrez]
AID - S0168-1702(16)30720-1 [pii]
AID - 10.1016/j.virusres.2017.01.017 [doi]
PST - ppublish
SO  - Virus Res. 2017 Mar 15;232:6-12. doi: 10.1016/j.virusres.2017.01.017. Epub 2017 
      Jan 22.