PMID- 28119248
OWN - NLM
STAT- MEDLINE
DCOM- 20170509
LR  - 20171210
IS  - 1096-0953 (Electronic)
IS  - 0013-9351 (Linking)
VI  - 154
DP  - 2017 Apr
TI  - Concentrations of vitamin A, E, thyroid and testosterone hormones in blood plasma 
      and tissues from emaciated adult male Arctic foxes (Vulpes lagopus) dietary 
      exposed to persistent organic pollutants (POPs).
PG  - 284-290
LID - S0013-9351(16)31205-1 [pii]
LID - 10.1016/j.envres.2017.01.017 [doi]
AB  - The aim of the present study was to investigate the relationships and effects of 
      oral POP exposure on retinol (vitamin A), alpha-tocopherol (vitamin E), thyroid 
      hormones and testosterone in emaciated adult farmed Arctic foxes. Eight 
      brother-pairs were exposed to either a diet containing naturally POP-contaminated 
      minke whale blubber (Balaenoptera acutorostrata) (n=8), or a control diet 
      containing pig (Sus scrofa) fat as the primary fat source (n=8) for 22 months. In 
      the whale blubber containing feed the  summation operatorPOPs concentration was 802ng/g w.w. and it 
      was 24ng/g w.w. in control feed. The liver mass was significantly higher and the 
      ratio of FT4 (free thyroxine):FT3 (free triiodothyronine) was significantly lower 
      in the POP exposed group as compared to the control group given feed with pig fat 
      (both p<0.05). The exposed group revealed lower plasma and liver concentrations 
      of alpha-tocopherol compared to the control group (both p<0.05). These results 
      indicate that plasma FT4:FT3 ratio and plasma and liver alpha-tocopherol are valuable 
      biomarker endpoints for chronic oral POP exposure in wild Arctic foxes. Based on 
      this we suggest that plasma FT4:FT3 ratio and plasma and liver alpha-tocopherol are 
      valuable biomarker endpoints for chronic POP exposure in wildlife Arctic foxes 
      and that these perturbations may affect their health status.
CI  - Copyright (c) 2017 Elsevier Inc. All rights reserved.
FAU - Rogstad, Tonje W
AU  - Rogstad TW
AD  - Department of Biology, Norwegian University of Science and Technology, NO-7491 
      Trondheim, Norway.
FAU - Sonne, Christian
AU  - Sonne C
AD  - Aarhus University, Faculty of Science and Technology, Department of Bioscience, 
      Arctic Research Centre (ARC), Frederiksborgvej 399, PO Box 358, DK-4000 Roskilde, 
      Denmark. Electronic address: cs@bios.au.dk.
FAU - Villanger, Gro D
AU  - Villanger GD
AD  - Department of Biology, Norwegian University of Science and Technology, NO-7491 
      Trondheim, Norway; Mental and Physical Health, Department of Child Health, 
      Norwegian Institute of Public Health, P.O. Box 4404 Nydalen, 0473 Oslo, Norway.
FAU - Ahlstom, Oystein
AU  - Ahlstom O
AD  - Department of Animal and Aquacultural Sciences, Norwegian University of Life 
      Sciences, N-1432 As, Norway.
FAU - Fuglei, Eva
AU  - Fuglei E
AD  - Norwegian Polar Institute, FRAM Centre, NO-9296 Tromso, Norway.
FAU - Muir, Derek C G
AU  - Muir DCG
AD  - National Water Research Institute, Environment Canada, Burlington, Ontario, 
      Canada L7R 4A6.
FAU - Jorgensen, Even
AU  - Jorgensen E
AD  - Department of Arctic and Marine Biology, UiT the Arctic University of Norway, 
      N-9037 Tromso, Norway.
FAU - Jenssen, Bjorn Munro
AU  - Jenssen BM
AD  - Department of Biology, Norwegian University of Science and Technology, NO-7491 
      Trondheim, Norway.
LA  - eng
PT  - Comparative Study
PT  - Journal Article
DEP - 20170122
PL  - Netherlands
TA  - Environ Res
JT  - Environmental research
JID - 0147621
RN  - 0 (Biomarkers)
RN  - 0 (Environmental Pollutants)
RN  - 0 (Thyroid Hormones)
RN  - 11103-57-4 (Vitamin A)
RN  - 1406-18-4 (Vitamin E)
RN  - 3XMK78S47O (Testosterone)
RN  - DFC2HB4I0K (Polychlorinated Biphenyls)
SB  - IM
MH  - Adipose Tissue/chemistry
MH  - Animals
MH  - Animals, Wild/blood
MH  - Arctic Regions
MH  - Biomarkers/blood
MH  - Diet/adverse effects
MH  - Emaciation/chemically induced
MH  - Environmental Exposure/adverse effects
MH  - Environmental Pollutants/*adverse effects/analysis
MH  - Foxes/blood
MH  - Liver/*chemistry
MH  - Male
MH  - Polychlorinated Biphenyls/*adverse effects/analysis
MH  - Swine
MH  - Testosterone/*blood
MH  - Thyroid Hormones/*blood
MH  - Vitamin A/*blood
MH  - Vitamin E/*blood
MH  - Whales
OTO - NOTNLM
OT  - Arctic, Endocrine disruption
OT  - Health effects, Oxidative stress
OT  - Pollution, Top predator
EDAT- 2017/01/26 06:00
MHDA- 2017/05/10 06:00
CRDT- 2017/01/26 06:00
PHST- 2016/12/07 00:00 [received]
PHST- 2017/01/12 00:00 [revised]
PHST- 2017/01/13 00:00 [accepted]
PHST- 2017/01/26 06:00 [pubmed]
PHST- 2017/05/10 06:00 [medline]
PHST- 2017/01/26 06:00 [entrez]
AID - S0013-9351(16)31205-1 [pii]
AID - 10.1016/j.envres.2017.01.017 [doi]
PST - ppublish
SO  - Environ Res. 2017 Apr;154:284-290. doi: 10.1016/j.envres.2017.01.017. Epub 2017 
      Jan 22.