PMID- 28120169
OWN - NLM
STAT- MEDLINE
DCOM- 20170807
LR  - 20220331
IS  - 1434-9949 (Electronic)
IS  - 0770-3198 (Linking)
VI  - 36
IP  - 4
DP  - 2017 Apr
TI  - Analysis of killer cell immunoglobulin-like receptors (KIRs) and their HLA ligand 
      genes polymorphisms in Iranian patients with systemic sclerosis.
PG  - 853-862
LID - 10.1007/s10067-016-3526-0 [doi]
AB  - Genetic factors have a great role in the pathogenesis of autoimmune diseases by 
      cooperating with environmental stimuli. Killer immunoglobulin-like receptors 
      (KIRs) are cell surface proteins on NK cells whose association with major 
      histocompatibility complex-I regulates their killing function. The aim of this 
      study was to provide information on the possible association between KIR and 
      human leukocyte antigen (HLA) genes with systemic sclerosis disease in Iranian 
      population. A total of 279 systemic sclerosis patients and 451 healthy controls 
      were enrolled in this case-control study in order to determine the presence or 
      absence of 19 KIR genes and 6 specific HLA class I ligands. DNA was analyzed by 
      polymerase chain reaction using the specific sequence primer method (PCR-SSP). 
      Among 11 discovered KIR genotypes, 6 genotypes showed a considerable role and 4 
      genotypes could preclude the risk of systemic sclerosis (SSc) disease. The 
      gene-gene interactions were also analyzed, and significant confounding effects 
      were seen between involved genes in these two combinations: "KIR3DL1; 
      HLA-BW4-Thr80" and "KIR3DL1 -HLA-BW4-A1." None of single KIR genes showed 
      significant effect on the risk of SSc. We conclude that there is an important 
      relationship between KIR genes and their HLA ligands with incidence rate of 
      systemic sclerosis in Iranian population. The powerful role of a number of 
      discovered KIR/HLA compounds such as activating KIR genotype 3 and HLA-BW4-A1 
      confirmed the provocative hypothesis of the interplay between activating or 
      inhibitory KIR genes with HLA ligands as a critical index of systemic sclerosis 
      predisposition.
FAU - Mahmoudi, Mahdi
AU  - Mahmoudi M
AD  - Rheumatology Research Center, Shariati Hospital, Tehran University of Medical 
      Sciences, Kargar Ave,, P.o. box: 1411713137, Tehran, Iran. mahmoudim@tums.ac.ir.
FAU - Fallahian, Faranak
AU  - Fallahian F
AD  - Cellular and Molecular Research Center, Qom University of Medical Sciences, Qom, 
      Iran.
FAU - Sobhani, Soheila
AU  - Sobhani S
AD  - Rheumatology Research Center, Shariati Hospital, Tehran University of Medical 
      Sciences, Kargar Ave,, P.o. box: 1411713137, Tehran, Iran.
FAU - Ghoroghi, Shima
AU  - Ghoroghi S
AD  - Rheumatology Research Center, Shariati Hospital, Tehran University of Medical 
      Sciences, Kargar Ave,, P.o. box: 1411713137, Tehran, Iran.
FAU - Jamshidi, Ahmadreza
AU  - Jamshidi A
AD  - Rheumatology Research Center, Shariati Hospital, Tehran University of Medical 
      Sciences, Kargar Ave,, P.o. box: 1411713137, Tehran, Iran.
FAU - Poursani, Shiva
AU  - Poursani S
AD  - Rheumatology Research Center, Shariati Hospital, Tehran University of Medical 
      Sciences, Kargar Ave,, P.o. box: 1411713137, Tehran, Iran.
FAU - Dolati, Masoumeh
AU  - Dolati M
AD  - Cellular and Molecular Research Center, Qom University of Medical Sciences, Qom, 
      Iran.
FAU - Hosseinpour, Zahra
AU  - Hosseinpour Z
AD  - Rheumatology Research Center, Shariati Hospital, Tehran University of Medical 
      Sciences, Kargar Ave,, P.o. box: 1411713137, Tehran, Iran.
FAU - Gharibdoost, Farhad
AU  - Gharibdoost F
AD  - Rheumatology Research Center, Shariati Hospital, Tehran University of Medical 
      Sciences, Kargar Ave,, P.o. box: 1411713137, Tehran, Iran. rrclab@tums.ac.ir.
LA  - eng
PT  - Journal Article
DEP - 20170124
PL  - Germany
TA  - Clin Rheumatol
JT  - Clinical rheumatology
JID - 8211469
RN  - 0 (HLA-B Antigens)
RN  - 0 (HLA-Bw4 antigen)
RN  - 0 (Receptors, KIR)
RN  - 0 (Receptors, KIR3DL1)
SB  - IM
MH  - Adult
MH  - Case-Control Studies
MH  - Female
MH  - Gene Frequency
MH  - Genotype
MH  - HLA-B Antigens/*genetics
MH  - Humans
MH  - Iran
MH  - Killer Cells, Natural/*metabolism
MH  - Male
MH  - Middle Aged
MH  - Polymorphism, Genetic
MH  - Receptors, KIR/*genetics
MH  - Receptors, KIR3DL1/*genetics
MH  - Scleroderma, Systemic/*genetics
OTO - NOTNLM
OT  - KIR
OT  - KIR HLA ligand
OT  - NK cell
OT  - Systemic sclerosis
EDAT- 2017/01/26 06:00
MHDA- 2017/08/08 06:00
CRDT- 2017/01/26 06:00
PHST- 2016/12/01 00:00 [received]
PHST- 2016/12/20 00:00 [accepted]
PHST- 2016/12/19 00:00 [revised]
PHST- 2017/01/26 06:00 [pubmed]
PHST- 2017/08/08 06:00 [medline]
PHST- 2017/01/26 06:00 [entrez]
AID - 10.1007/s10067-016-3526-0 [pii]
AID - 10.1007/s10067-016-3526-0 [doi]
PST - ppublish
SO  - Clin Rheumatol. 2017 Apr;36(4):853-862. doi: 10.1007/s10067-016-3526-0. Epub 2017 
      Jan 24.