PMID- 28121989
OWN - NLM
STAT- MEDLINE
DCOM- 20170810
LR  - 20220330
IS  - 1932-6203 (Electronic)
IS  - 1932-6203 (Linking)
VI  - 12
IP  - 1
DP  - 2017
TI  - Reduced Ectopic Pregnancy Rate on Day 5 Embryo Transfer Compared with Day 3: A 
      Meta-Analysis.
PG  - e0169837
LID - 10.1371/journal.pone.0169837 [doi]
LID - e0169837
AB  - OBJECTIVE: To compare the risk of ectopic pregnancy (EP) after embryo transfer on 
      day 3(D3-ET) and day 5(D5-ET). DESIGN: Meta-analysis. PATIENTS: Women with 
      pregnancy resulting from in vitro undergoing in vitro fertilization (IVF) or 
      intracytoplasmic sperm injection (ICSI). RESULT(S): Twenty-two studies were 
      identified through research conducted using the PubMed, Embase, and Cochrane 
      databases and ClinicalTrials.gov. All studies were conducted prior to October 
      2016. Adding the reproductive data from our center, a total of 143 643 
      pregnancies were reviewed(D3-ET: n = 62027,D5-ET:n = 81616). A lower EP rate was 
      found in women undergoing D5-ET than in those undergoing D3-ET [relative risk 
      (RR), 0.67;95% confidence interval (CI), 0.54-0.85;143643 pregnancies in 23 
      studies; I2 = 67%]. These results were validated in subgroups of fresh 
      embryo-transfer (Fre-ET) cycles [RR, 0.78; 95%CI, 0.69-0.88; 91 871 pregnancies 
      in 21 studies; I2 = 29%] and frozen-thawed embryo-transfer (Fro-ET) cycles [RR, 
      0.43; 95%CI, 0.36-0.51; 51 772 pregnancies in 10 studies; I2 = 33%]. After 
      separating out the randomized controlled trials (RCTs), a significant difference 
      was found in the retrospective studies in both subgroups [both Fre-ET 
      (RR,0.78;95% CI 0.69-0.88);91182 pregnancies in 14 studies; I2 = 45%] and 
      Fro-ET(RR,0.43;95% CI 0.36-0.51; 51751pregnancies in 9 studies;I2 = 33%)], while 
      the RCTs showed no statistical significance for Fre-ET cycles[RR,0.86;95% CI 
      0.32-2.26); 689 pregnancies in 7 studies; I2 = 0%]. CONCLUSION(S): The present 
      study indicates that D5-ET reduces the risk for EP in cycles that use IVF or 
      ICSI, compared with D3-ET. It suggests that D5-ET may be a better choice for 
      decreasing the EP rate in assisted reproductive technology. Further high-quality 
      randomized controlled trials are anticipated.
FAU - Zhang, Bingqian
AU  - Zhang B
AD  - Center for Reproductive Medicine, Shandong Provincial Hospital Affiliated to 
      Shandong University, Jinan, China.
AD  - National Research Center for Assisted Reproductive Technology and Reproductive 
      Genetics, Jinan, China.
AD  - The Key laboratory of Reproductive Endocrinology (Shandong University), Ministry 
      of Education, Jinan, China.
FAU - Cui, Linlin
AU  - Cui L
AD  - Center for Reproductive Medicine, Shandong Provincial Hospital Affiliated to 
      Shandong University, Jinan, China.
AD  - National Research Center for Assisted Reproductive Technology and Reproductive 
      Genetics, Jinan, China.
AD  - The Key laboratory of Reproductive Endocrinology (Shandong University), Ministry 
      of Education, Jinan, China.
FAU - Tang, Rong
AU  - Tang R
AD  - Center for Reproductive Medicine, Shandong Provincial Hospital Affiliated to 
      Shandong University, Jinan, China.
AD  - National Research Center for Assisted Reproductive Technology and Reproductive 
      Genetics, Jinan, China.
AD  - The Key laboratory of Reproductive Endocrinology (Shandong University), Ministry 
      of Education, Jinan, China.
FAU - Ding, Lingling
AU  - Ding L
AD  - Center for Reproductive Medicine, Shandong Provincial Hospital Affiliated to 
      Shandong University, Jinan, China.
AD  - National Research Center for Assisted Reproductive Technology and Reproductive 
      Genetics, Jinan, China.
AD  - The Key laboratory of Reproductive Endocrinology (Shandong University), Ministry 
      of Education, Jinan, China.
FAU - Yan, Lei
AU  - Yan L
AD  - Center for Reproductive Medicine, Shandong Provincial Hospital Affiliated to 
      Shandong University, Jinan, China.
AD  - National Research Center for Assisted Reproductive Technology and Reproductive 
      Genetics, Jinan, China.
AD  - The Key laboratory of Reproductive Endocrinology (Shandong University), Ministry 
      of Education, Jinan, China.
FAU - Chen, Zi-Jiang
AU  - Chen ZJ
AD  - Center for Reproductive Medicine, Shandong Provincial Hospital Affiliated to 
      Shandong University, Jinan, China.
AD  - National Research Center for Assisted Reproductive Technology and Reproductive 
      Genetics, Jinan, China.
AD  - The Key laboratory of Reproductive Endocrinology (Shandong University), Ministry 
      of Education, Jinan, China.
AD  - Center for Reproductive Medicine, Ren Ji Hospital, School of Medicine, Shanghai 
      Jiao Tong University, Shanghai, China.
AD  - Shanghai Key Laboratory for Assisted Reproduction and Reproductive Genetics, 
      Shanghai, China.
LA  - eng
PT  - Journal Article
PT  - Meta-Analysis
DEP - 20170125
PL  - United States
TA  - PLoS One
JT  - PloS one
JID - 101285081
SB  - IM
MH  - Embryo Transfer/adverse effects/*methods
MH  - Female
MH  - Fertilization in Vitro/adverse effects/*methods
MH  - Humans
MH  - Incidence
MH  - Pregnancy
MH  - Pregnancy Rate
MH  - Pregnancy, Ectopic/*epidemiology/etiology
MH  - Risk Factors
MH  - Time Factors
PMC - PMC5266274
COIS- The authors have declared that no competing interests exist.
EDAT- 2017/01/26 06:00
MHDA- 2017/08/11 06:00
PMCR- 2017/01/25
CRDT- 2017/01/26 06:00
PHST- 2016/11/07 00:00 [received]
PHST- 2016/12/22 00:00 [accepted]
PHST- 2017/01/26 06:00 [entrez]
PHST- 2017/01/26 06:00 [pubmed]
PHST- 2017/08/11 06:00 [medline]
PHST- 2017/01/25 00:00 [pmc-release]
AID - PONE-D-16-44244 [pii]
AID - 10.1371/journal.pone.0169837 [doi]
PST - epublish
SO  - PLoS One. 2017 Jan 25;12(1):e0169837. doi: 10.1371/journal.pone.0169837. 
      eCollection 2017.