PMID- 28122647
OWN - NLM
STAT- MEDLINE
DCOM- 20171212
LR  - 20220310
IS  - 1756-8722 (Electronic)
IS  - 1756-8722 (Linking)
VI  - 10
IP  - 1
DP  - 2017 Jan 25
TI  - MiR-194 functions as a tumor suppressor in laryngeal squamous cell carcinoma by 
      targeting Wee1.
PG  - 32
LID - 10.1186/s13045-017-0402-6 [doi]
LID - 32
AB  - The emerging roles of microRNAs (miRs) have been deeply investigated in cancer. 
      However, the role of miR-194 in human laryngeal squamous cell carcinoma (LSCC) is 
      still unclear. Here, we have demonstrated that miR-194 is significantly 
      downregulated in LSCC tissues and cells, and overexpression of miR-194 inhibits 
      the proliferation, migration, invasion, and drug resistance in LSCC cells. 
      Moreover, Wee1 is identified as a novel direct target of miR-194. Ectopic 
      expression of Wee1 at least in part overcomes the suppressive impacts of miR-194 
      on the malignant phenotypes of LSCC. Overall, our study provides new sights into 
      the role of miR-194/Wee1 axis in LSCC and suggests a novel miR-194/Wee1-based 
      clinical application for LSCC patients.
FAU - Li, Pei
AU  - Li P
AD  - Department of Otolaryngology-Head and Neck Surgery, The Third Affiliated 
      Hospital, Sun Yat-sen University, Guangzhou, Guangdong, China.
FAU - Yang, Yang
AU  - Yang Y
AD  - Department of Cell Biology & Institute of Biomedicine, National Engineering 
      Research Center of Genetic Medicine, Guangdong Provincial Key Laboratory of 
      Bioengineering Medicine, College of Life Science and Technology, Jinan 
      University, Guangzhou, Guangdong, China.
FAU - Liu, Hui
AU  - Liu H
AD  - Division of Pulmonary and Critical Care, Department of Internal Medicine, The 
      Third Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong, China.
FAU - Yang, An-Kui
AU  - Yang AK
AD  - Department of Head and Neck, State Key Laboratory of Oncology in South China, 
      Collaborative Innovation Center for Cancer Medicine, Sun Yat-sen University 
      Cancer Center, Guangzhou, Guangdong, China.
FAU - Di, Jin-Ming
AU  - Di JM
AD  - Department of Urology, The Third Affiliated Hospital, Sun Yat-sen University, 
      Guangzhou, Guangdong, China.
FAU - Tan, Guang-Mou
AU  - Tan GM
AD  - Department of Head & Neck Surgery, Affiliated Cancer Hospital & Institute of 
      Guangzhou Medical University, Guangzhou, China.
FAU - Wang, Hai-Feng
AU  - Wang HF
AD  - Department of Otolaryngology-Head and Neck Surgery, The Third Affiliated 
      Hospital, Sun Yat-sen University, Guangzhou, Guangdong, China.
FAU - Qiu, Jian-Ge
AU  - Qiu JG
AD  - Department of Cell Biology & Institute of Biomedicine, National Engineering 
      Research Center of Genetic Medicine, Guangdong Provincial Key Laboratory of 
      Bioengineering Medicine, College of Life Science and Technology, Jinan 
      University, Guangzhou, Guangdong, China.
FAU - Zhang, Wen-Ji
AU  - Zhang WJ
AD  - Department of Cell Biology & Institute of Biomedicine, National Engineering 
      Research Center of Genetic Medicine, Guangdong Provincial Key Laboratory of 
      Bioengineering Medicine, College of Life Science and Technology, Jinan 
      University, Guangzhou, Guangdong, China.
FAU - Jiang, Qi-Wei
AU  - Jiang QW
AD  - Department of Cell Biology & Institute of Biomedicine, National Engineering 
      Research Center of Genetic Medicine, Guangdong Provincial Key Laboratory of 
      Bioengineering Medicine, College of Life Science and Technology, Jinan 
      University, Guangzhou, Guangdong, China.
FAU - Zheng, Di-Wei
AU  - Zheng DW
AD  - Department of Cell Biology & Institute of Biomedicine, National Engineering 
      Research Center of Genetic Medicine, Guangdong Provincial Key Laboratory of 
      Bioengineering Medicine, College of Life Science and Technology, Jinan 
      University, Guangzhou, Guangdong, China.
FAU - Chen, Yao
AU  - Chen Y
AD  - Department of Cell Biology & Institute of Biomedicine, National Engineering 
      Research Center of Genetic Medicine, Guangdong Provincial Key Laboratory of 
      Bioengineering Medicine, College of Life Science and Technology, Jinan 
      University, Guangzhou, Guangdong, China.
FAU - Wei, Meng-Ning
AU  - Wei MN
AD  - Department of Cell Biology & Institute of Biomedicine, National Engineering 
      Research Center of Genetic Medicine, Guangdong Provincial Key Laboratory of 
      Bioengineering Medicine, College of Life Science and Technology, Jinan 
      University, Guangzhou, Guangdong, China.
FAU - Huang, Jia-Rong
AU  - Huang JR
AD  - Department of Cell Biology & Institute of Biomedicine, National Engineering 
      Research Center of Genetic Medicine, Guangdong Provincial Key Laboratory of 
      Bioengineering Medicine, College of Life Science and Technology, Jinan 
      University, Guangzhou, Guangdong, China.
FAU - Wang, Kun
AU  - Wang K
AD  - Department of Cell Biology & Institute of Biomedicine, National Engineering 
      Research Center of Genetic Medicine, Guangdong Provincial Key Laboratory of 
      Bioengineering Medicine, College of Life Science and Technology, Jinan 
      University, Guangzhou, Guangdong, China.
FAU - Shi, Zhi
AU  - Shi Z
AUID- ORCID: 0000-0002-8328-0305
AD  - Department of Cell Biology & Institute of Biomedicine, National Engineering 
      Research Center of Genetic Medicine, Guangdong Provincial Key Laboratory of 
      Bioengineering Medicine, College of Life Science and Technology, Jinan 
      University, Guangzhou, Guangdong, China. tshizhi@jnu.edu.cn.
FAU - Ye, Jin
AU  - Ye J
AD  - Department of Otolaryngology-Head and Neck Surgery, The Third Affiliated 
      Hospital, Sun Yat-sen University, Guangzhou, Guangdong, China.
LA  - eng
PT  - Letter
PT  - Research Support, Non-U.S. Gov't
DEP - 20170125
PL  - England
TA  - J Hematol Oncol
JT  - Journal of hematology & oncology
JID - 101468937
RN  - 0 (Cell Cycle Proteins)
RN  - 0 (MIRN194 microRNA, human)
RN  - 0 (MicroRNAs)
RN  - 0 (Nuclear Proteins)
RN  - EC 2.7.10.1 (Protein-Tyrosine Kinases)
RN  - EC 2.7.10.2 (WEE1 protein, human)
SB  - IM
MH  - Biopsy
MH  - Carcinoma, Squamous Cell/*pathology
MH  - Cell Cycle Proteins/antagonists & inhibitors/*metabolism
MH  - Cell Line, Tumor
MH  - Cell Movement
MH  - Cell Proliferation
MH  - Drug Resistance, Neoplasm
MH  - Gene Expression Regulation, Neoplastic
MH  - Humans
MH  - Laryngeal Neoplasms/*pathology
MH  - MicroRNAs/metabolism/*physiology
MH  - Neoplasm Invasiveness
MH  - Nuclear Proteins/antagonists & inhibitors/*metabolism
MH  - Protein-Tyrosine Kinases/antagonists & inhibitors/*metabolism
PMC - PMC5264457
OTO - NOTNLM
OT  - Laryngeal squamous cell carcinoma
OT  - Wee1
OT  - miR-194
EDAT- 2017/01/27 06:00
MHDA- 2017/12/13 06:00
PMCR- 2017/01/25
CRDT- 2017/01/27 06:00
PHST- 2016/12/24 00:00 [received]
PHST- 2017/01/13 00:00 [accepted]
PHST- 2017/01/27 06:00 [entrez]
PHST- 2017/01/27 06:00 [pubmed]
PHST- 2017/12/13 06:00 [medline]
PHST- 2017/01/25 00:00 [pmc-release]
AID - 10.1186/s13045-017-0402-6 [pii]
AID - 402 [pii]
AID - 10.1186/s13045-017-0402-6 [doi]
PST - epublish
SO  - J Hematol Oncol. 2017 Jan 25;10(1):32. doi: 10.1186/s13045-017-0402-6.