PMID- 28122839
OWN - NLM
STAT- MEDLINE
DCOM- 20171023
LR  - 20221207
IS  - 1935-5548 (Electronic)
IS  - 0149-5992 (Print)
IS  - 0149-5992 (Linking)
VI  - 40
IP  - 4
DP  - 2017 Apr
TI  - Nondiabetic Glucometabolic Status and Progression of Aortic Stiffness: The 
      Whitehall II Study.
PG  - 599-606
LID - 10.2337/dc16-1773 [doi]
AB  - OBJECTIVE: Aortic stiffness is an important predictor of future morbidity and 
      mortality. Diabetes is associated with increased aortic stiffness, but the 
      importance of nondiabetic glucometabolic status for accelerated aortic stiffening 
      is unclear. We tested the hypothesis that adverse glucometabolic status is 
      associated with accelerated aortic stiffening in individuals without diabetes, 
      independently of known risk factors for arterial stiffening. RESEARCH DESIGN AND 
      METHODS: Glucometabolic status and other cardiovascular risk factors were 
      assessed at baseline in 2008-09, and carotid femoral pulse wave velocity (cfPWV) 
      at baseline and follow-up in 2012-13, in 4,386 participants without diabetes of 
      the Whitehall II Study. RESULTS: The mean age of the cohort at cfPWV baseline was 
      60 years, and 74% were male. cfPWV increased from (mean +/- SE) 8.30 +/- 0.03 to 8.98 
      +/- 0.04 m/s during 4 years of follow-up. At baseline, cfPWV was associated with 
      fasting and 2-h postload glucose, HbA(1c), and HOMA-insulin resistance (HOMA-IR). 
      HbA(1c) and HOMA-IR were associated with progression of cfPWV after adjusting for 
      physiological confounders and cardiovascular risk factors. A 1 SD higher HbA(1c) 
      and HOMA-IR were associated with greater increases in cfPWV (0.11 m/s per 5 years 
      [95% CI 0.04, 0.18], P = 0.003 and 0.09 m/s per 5 years [0.01, 0.17], P = 0.03, 
      respectively). Additional adjustment for BMI weakened the association with 
      HOMA-IR but not with HbA(1c). CONCLUSIONS: HbA(1c) is independently associated 
      with accelerated progression of aortic stiffness in individuals without diabetes. 
      These findings suggest that long-term glucometabolic status, even in individuals 
      without diabetes, could be an important target for preventative strategies 
      against vascular aging.
CI  - (c) 2017 by the American Diabetes Association.
FAU - McEniery, Carmel M
AU  - McEniery CM
AUID- ORCID: 0000-0003-3636-0705
AD  - Division of Experimental Medicine and Immunotherapeutics, University of 
      Cambridge, Cambridge, U.K. cmm41@cam.ac.uk.
FAU - Wilkinson, Ian B
AU  - Wilkinson IB
AD  - Division of Experimental Medicine and Immunotherapeutics, University of 
      Cambridge, Cambridge, U.K.
FAU - Johansen, Nanna B
AU  - Johansen NB
AD  - Steno Diabetes Center A/S, Gentofte, Denmark.
AD  - Danish Diabetes Academy, Odense, Denmark.
FAU - Witte, Daniel R
AU  - Witte DR
AD  - Danish Diabetes Academy, Odense, Denmark.
AD  - Department of Public Health, Aarhus University, Aarhus, Denmark.
FAU - Singh-Manoux, Archana
AU  - Singh-Manoux A
AD  - Research Department of Epidemiology and Public Health, University College London, 
      London, U.K.
FAU - Kivimaki, Mika
AU  - Kivimaki M
AD  - Research Department of Epidemiology and Public Health, University College London, 
      London, U.K.
FAU - Tabak, Adam G
AU  - Tabak AG
AD  - Research Department of Epidemiology and Public Health, University College London, 
      London, U.K.
AD  - 1st Department of Medicine, Faculty of Medicine, Semmelweis University, Budapest, 
      Hungary.
FAU - Brunner, Eric J
AU  - Brunner EJ
AD  - Research Department of Epidemiology and Public Health, University College London, 
      London, U.K.
FAU - Shipley, Martin J
AU  - Shipley MJ
AD  - Research Department of Epidemiology and Public Health, University College London, 
      London, U.K.
LA  - eng
GR  - MR/K013351/1/MRC_/Medical Research Council/United Kingdom
GR  - RG/16/11/32334/BHF_/British Heart Foundation/United Kingdom
GR  - R01 HL036310/HL/NHLBI NIH HHS/United States
GR  - FS/12/8/29377/BHF_/British Heart Foundation/United Kingdom
GR  - R01 AG034454/AG/NIA NIH HHS/United States
GR  - RG/13/2/30098/BHF_/British Heart Foundation/United Kingdom
GR  - PG/11/63/29011/BHF_/British Heart Foundation/United Kingdom
GR  - R01 AG013196/AG/NIA NIH HHS/United States
PT  - Journal Article
PT  - Observational Study
DEP - 20170125
PL  - United States
TA  - Diabetes Care
JT  - Diabetes care
JID - 7805975
RN  - 0 (Blood Glucose)
RN  - 0 (Glycated Hemoglobin A)
SB  - IM
MH  - Adult
MH  - Blood Glucose/metabolism
MH  - Cardiovascular Diseases/*blood/etiology
MH  - Cross-Sectional Studies
MH  - Diabetes Mellitus
MH  - Disease Progression
MH  - Female
MH  - Follow-Up Studies
MH  - Glycated Hemoglobin/*metabolism
MH  - Humans
MH  - Insulin Resistance
MH  - Longitudinal Studies
MH  - Male
MH  - Metabolic Diseases/*blood/complications/diagnosis
MH  - Middle Aged
MH  - Prospective Studies
MH  - Pulse Wave Analysis
MH  - Risk Factors
MH  - *Vascular Stiffness
PMC - PMC5360278
MID - EMS71469
EDAT- 2017/01/27 06:00
MHDA- 2017/10/24 06:00
PMCR- 2018/04/01
CRDT- 2017/01/27 06:00
PHST- 2016/08/16 00:00 [received]
PHST- 2017/01/06 00:00 [accepted]
PHST- 2017/01/27 06:00 [pubmed]
PHST- 2017/10/24 06:00 [medline]
PHST- 2017/01/27 06:00 [entrez]
PHST- 2018/04/01 00:00 [pmc-release]
AID - dc16-1773 [pii]
AID - 1773 [pii]
AID - 10.2337/dc16-1773 [doi]
PST - ppublish
SO  - Diabetes Care. 2017 Apr;40(4):599-606. doi: 10.2337/dc16-1773. Epub 2017 Jan 25.