PMID- 2812331
OWN - NLM
STAT- MEDLINE
DCOM- 19891218
LR  - 20190514
IS  - 0028-3878 (Print)
IS  - 0028-3878 (Linking)
VI  - 39
IP  - 11
DP  - 1989 Nov
TI  - Narcolepsy associated with lesions of the diencephalon.
PG  - 1505-8
AB  - Although symptomatic narcolepsy, or narcolepsy due to identifiable brain lesions, 
      was once thought to be common, there are few well-documented reported cases since 
      the discovery of the association of REM sleep abnormalities with narcolepsy. Even 
      fewer such reports have been accompanied by human leukocyte antigen (HLA) 
      testing. We report 3 patients who fulfill criteria for symptomatic narcolepsy, 1 
      with a craniopharyngioma, the 2nd with a hypothalamic syndrome of unknown 
      etiology, and the 3rd with obstructive hydrocephalus and a sarcoid granuloma in 
      the region of the 3rd ventricle. The first 2 were positive for HLA-DR2 while the 
      3rd was negative for the HLA-DR2 and HLA-DQwl antigens. These findings suggest 
      that diencephalic lesions can be associated with signs and symptoms of narcolepsy 
      that are clinically indistinguishable from those of idiopathic narcolepsy, and 
      that the HLA-DR2 antigen is not required in all cases of symptomatic narcolepsy.
FAU - Aldrich, M S
AU  - Aldrich MS
AD  - Department of Neurology, University of Michigan Medical Center, Ann Arbor 
      48109-0316.
FAU - Naylor, M W
AU  - Naylor MW
LA  - eng
PT  - Case Reports
PT  - Journal Article
PL  - United States
TA  - Neurology
JT  - Neurology
JID - 0401060
RN  - 0 (HLA-DQ Antigens)
RN  - 0 (HLA-DQ1 antigen)
RN  - 0 (HLA-DR Antigens)
SB  - IM
MH  - Adult
MH  - Brain/diagnostic imaging/pathology
MH  - Brain Diseases/complications
MH  - Child
MH  - *Diencephalon
MH  - Female
MH  - HLA-DQ Antigens
MH  - HLA-DR Antigens/analysis
MH  - Humans
MH  - Magnetic Resonance Imaging
MH  - Narcolepsy/*etiology/immunology
MH  - Sleep Stages
MH  - Sleep Wake Disorders/etiology
MH  - Sleep, REM
MH  - Tomography, X-Ray Computed
EDAT- 1989/11/01 00:00
MHDA- 1989/11/01 00:01
CRDT- 1989/11/01 00:00
PHST- 1989/11/01 00:00 [pubmed]
PHST- 1989/11/01 00:01 [medline]
PHST- 1989/11/01 00:00 [entrez]
AID - 10.1212/wnl.39.11.1505 [doi]
PST - ppublish
SO  - Neurology. 1989 Nov;39(11):1505-8. doi: 10.1212/wnl.39.11.1505.