PMID- 28123453
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20201001
IS  - 1758-5996 (Print)
IS  - 1758-5996 (Electronic)
IS  - 1758-5996 (Linking)
VI  - 9
DP  - 2017
TI  - Interaction between peroxisome proliferator-activated receptor gamma polymorphism 
      and obesity on type 2 diabetes in a Chinese Han population.
PG  - 7
LID - 10.1186/s13098-017-0205-5 [doi]
LID - 7
AB  - AIMS: The aim of this study was to investigate the association of four single 
      nucleotide polymorphisms (SNPs) of peroxisome proliferator-activated receptor 
      gamma (PPARG) with type 2 diabetes mellitus (T2DM) risk and additional role of 
      gene-obesity interaction. METHODS: Four SNPs were selected for genotyping in the 
      case-control study: rs1805192, rs709158, rs3856806 and rs4684847. Generalized 
      multifactor dimensionality reduction (GMDR) model and logistic regression was 
      used to examine the interaction between SNP and obesity on T2DM, odds ratio (OR) 
      and 95% confident interval (95% CI) were calculated. RESULTS: T2DM risk was 
      significantly higher in individuals with rs1805192-G allele (p < 0.05). The 
      carriers of G allele of the rs1805192 polymorphism revealed increased T2DM risk 
      than those with CC variants (CG + GG versus CC, adjusted OR (95% CI) 1.76 
      (1.45-2.06), p < 0.001). T2DM risk was also significantly higher in individuals 
      with rs3856806-T allele (p < 0.05). The carriers of T allele of the rs3856806 
      polymorphism revealed increased T2DM risk than those with CC variants (CT + TT 
      versus CC, adjusted OR (95% CI) 1.25 (1.17-1.76), p < 0.001). There was a 
      significant two-locus model (p = 0.0107) involving rs1805192 and obesity. Obese 
      subjects with CG or GG genotype have the highest T2DM risk, compared to subjects 
      with CC genotype and normal BMI (OR 2.40, 95% CI 1.68-3.63). CONCLUSIONS: Our 
      results support an important association between rs1805192 and rs3856806 minor 
      allele (G allele) of PPARG and increased T2DM risk, the interaction analysis 
      shown a combined effect of G- obesity interaction between rs1805192 and obesity 
      on increased T2DM risk.
FAU - Lv, Xiaohui
AU  - Lv X
AD  - Shenzhen Futian District Traditional Chinese Medicine Hospital, No. 6001 in North 
      Central Avenue, Futian District, Shenzhen, 518033 Guangdong China.
FAU - Zhang, Li
AU  - Zhang L
AD  - Shenzhen Futian District Traditional Chinese Medicine Hospital, No. 6001 in North 
      Central Avenue, Futian District, Shenzhen, 518033 Guangdong China.
FAU - Sun, Jiayu
AU  - Sun J
AD  - Shenzhen Futian District Traditional Chinese Medicine Hospital, No. 6001 in North 
      Central Avenue, Futian District, Shenzhen, 518033 Guangdong China.
FAU - Cai, Zhigang
AU  - Cai Z
AD  - Shenzhen Futian District Traditional Chinese Medicine Hospital, No. 6001 in North 
      Central Avenue, Futian District, Shenzhen, 518033 Guangdong China.
FAU - Gu, Qing
AU  - Gu Q
AD  - Shenzhen Futian District Traditional Chinese Medicine Hospital, No. 6001 in North 
      Central Avenue, Futian District, Shenzhen, 518033 Guangdong China.
FAU - Zhang, Ruipeng
AU  - Zhang R
AD  - Key Lab for New Drugs Research of TCM, Research Institute of Tsinghua University 
      in Shenzhen, Shenzhen, Guangdong China. ISNI: 0000 0001 0662 3178. GRID: 
      grid.12527.33
FAU - Shan, Aiyun
AU  - Shan A
AD  - Shenzhen Futian District Traditional Chinese Medicine Hospital, No. 6001 in North 
      Central Avenue, Futian District, Shenzhen, 518033 Guangdong China.
LA  - eng
PT  - Journal Article
DEP - 20170119
PL  - England
TA  - Diabetol Metab Syndr
JT  - Diabetology & metabolic syndrome
JID - 101488958
PMC - PMC5248486
OTO - NOTNLM
OT  - Interaction
OT  - Obesity
OT  - PPAR
OT  - Polymorphism
OT  - Type 2 diabetes mellitus
EDAT- 2017/01/27 06:00
MHDA- 2017/01/27 06:01
PMCR- 2017/01/19
CRDT- 2017/01/27 06:00
PHST- 2016/06/24 00:00 [received]
PHST- 2017/01/13 00:00 [accepted]
PHST- 2017/01/27 06:00 [entrez]
PHST- 2017/01/27 06:00 [pubmed]
PHST- 2017/01/27 06:01 [medline]
PHST- 2017/01/19 00:00 [pmc-release]
AID - 205 [pii]
AID - 10.1186/s13098-017-0205-5 [doi]
PST - epublish
SO  - Diabetol Metab Syndr. 2017 Jan 19;9:7. doi: 10.1186/s13098-017-0205-5. 
      eCollection 2017.