PMID- 28123479
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20201001
IS  - 1792-0981 (Print)
IS  - 1792-1015 (Electronic)
IS  - 1792-0981 (Linking)
VI  - 13
IP  - 1
DP  - 2017 Jan
TI  - Three single nucleotide polymorphisms associated with type 2 diabetes mellitus in 
      a Chinese population.
PG  - 121-126
LID - 10.3892/etm.2016.3920 [doi]
AB  - An Indian study recently observed three new loci: rs9552911 in the SGCG, 
      rs1593304 near PLXNA4 and rs4858889 in SCAP associated with type 2 diabetes 
      mellitus (T2DM) in a south Asian population. The present study aimed to validate 
      these findings in a Chinese population. We genotyped the above three 
      single-nucleotide polymorphisms (SNPs), rs9552911, rs1593304, and rs4858889, in a 
      group of 1,972 Chinese individuals, comprising of 966 type 2 diabetic patients 
      and 976 controls. Anthropometric variables and biochemical traits were measured 
      in all the participants. The association analyses of genotype-disease and 
      genotype-traits were estimated. The genotype frequency of rs9552911 differed 
      statistically between the cases and controls (P=0.017). The difference was also 
      evident between the cases and controls in non-obese participants (P=0.033). In 
      addition, the SNP rs9552911 was associated with weight (P=0.033), total 
      cholesterol (P=0.006) and low-density lipoprotein-cholesterol (P=0.007). The SNP 
      rs1593304 was associated with beta-cell function estimated by the homeostatic model 
      assessment of beta-cell function (P=0.041). However, there was no significant 
      association between rs4858889 and T2DM. In conclusion, the results show that the 
      SNP rs9552911 was associated with T2DM, possibly by affecting body mass index and 
      lipid metabolism. The SNP rs1593304 may impair beta-cell function.
FAU - Chen, Meijun
AU  - Chen M
AD  - Department of Endocrinology, The Second Affiliated Hospital of Harbin Medical 
      University, Harbin, Heilongjiang 150001, P.R. China.
FAU - Zhang, Xuelong
AU  - Zhang X
AD  - Laboratory of Medical Genetics, Harbin Medical University, Harbin, Heilongjiang 
      150001, P.R. China.
FAU - Fang, Qingxiao
AU  - Fang Q
AD  - Department of Endocrinology, The Second Affiliated Hospital of Harbin Medical 
      University, Harbin, Heilongjiang 150001, P.R. China.
FAU - Wang, Tongtong
AU  - Wang T
AD  - Department of Endocrinology, The Second Affiliated Hospital of Harbin Medical 
      University, Harbin, Heilongjiang 150001, P.R. China.
FAU - Li, Tingting
AU  - Li T
AD  - Department of Endocrinology, The Second Affiliated Hospital of Harbin Medical 
      University, Harbin, Heilongjiang 150001, P.R. China.
FAU - Qiao, Hong
AU  - Qiao H
AD  - Department of Endocrinology, The Second Affiliated Hospital of Harbin Medical 
      University, Harbin, Heilongjiang 150001, P.R. China.
LA  - eng
PT  - Journal Article
DEP - 20161118
PL  - Greece
TA  - Exp Ther Med
JT  - Experimental and therapeutic medicine
JID - 101531947
PMC - PMC5244830
OTO - NOTNLM
OT  - PLXNA4: rs1593304
OT  - SCAP: rs4858889
OT  - SGCG: rs9552911
OT  - single-nucleotide polymorphisms
OT  - type 2 diabetes mellitus
EDAT- 2017/01/27 06:00
MHDA- 2017/01/27 06:01
PMCR- 2016/11/18
CRDT- 2017/01/27 06:00
PHST- 2016/08/17 00:00 [received]
PHST- 2016/11/10 00:00 [accepted]
PHST- 2017/01/27 06:00 [entrez]
PHST- 2017/01/27 06:00 [pubmed]
PHST- 2017/01/27 06:01 [medline]
PHST- 2016/11/18 00:00 [pmc-release]
AID - ETM-0-0-3920 [pii]
AID - 10.3892/etm.2016.3920 [doi]
PST - ppublish
SO  - Exp Ther Med. 2017 Jan;13(1):121-126. doi: 10.3892/etm.2016.3920. Epub 2016 Nov 
      18.