PMID- 28124577
OWN - NLM
STAT- MEDLINE
DCOM- 20170621
LR  - 20211204
IS  - 1549-7798 (Electronic)
IS  - 1040-9238 (Print)
IS  - 1040-9238 (Linking)
VI  - 52
IP  - 3
DP  - 2017 Jun
TI  - Mammalian target of rapamycin (mTOR): a central regulator of male fertility?
PG  - 235-253
LID - 10.1080/10409238.2017.1279120 [doi]
AB  - Mammalian target of rapamycin (mTOR) is a central regulator of cellular metabolic 
      phenotype and is involved in virtually all aspects of cellular function. It 
      integrates not only nutrient and energy-sensing pathways but also actin 
      cytoskeleton organization, in response to environmental cues including growth 
      factors and cellular energy levels. These events are pivotal for spermatogenesis 
      and determine the reproductive potential of males. Yet, the molecular mechanisms 
      by which mTOR signaling acts in male reproductive system remain a matter of 
      debate. Here, we review the current knowledge on physiological and molecular 
      events mediated by mTOR in testis and testicular cells. In recent years, mTOR 
      inhibition has been explored as a prime strategy to develop novel therapeutic 
      approaches to treat cancer, cardiovascular disease, autoimmunity, and metabolic 
      disorders. However, the physiological consequences of mTOR dysregulation and 
      inhibition to male reproductive potential are still not fully understood. 
      Compelling evidence suggests that mTOR is an arising regulator of male fertility 
      and better understanding of this atypical protein kinase coordinated action in 
      testis will provide insightful information concerning its biological significance 
      in other tissues/organs. We also discuss why a new generation of mTOR inhibitors 
      aiming to be used in clinical practice may also need to include an integrative 
      view on the effects in male reproductive system.
FAU - Jesus, Tito T
AU  - Jesus TT
AD  - a Laboratory of Cell Biology, Department of Microscopy and Unit for 
      Multidisciplinary Research in Biomedicine (UMIB), Institute of Biomedical 
      Sciences Abel Salazar (ICBAS), University of Porto , Porto , Portugal.
AD  - b CICS-UBI - Health Sciences Research Centre, University of Beira Interior , 
      Covilha , Portugal.
FAU - Oliveira, Pedro F
AU  - Oliveira PF
AD  - a Laboratory of Cell Biology, Department of Microscopy and Unit for 
      Multidisciplinary Research in Biomedicine (UMIB), Institute of Biomedical 
      Sciences Abel Salazar (ICBAS), University of Porto , Porto , Portugal.
AD  - c i3S - Instituto de Investigacao e Inovacao em Saude, University of Porto , 
      Porto , Portugal.
FAU - Sousa, Mario
AU  - Sousa M
AD  - a Laboratory of Cell Biology, Department of Microscopy and Unit for 
      Multidisciplinary Research in Biomedicine (UMIB), Institute of Biomedical 
      Sciences Abel Salazar (ICBAS), University of Porto , Porto , Portugal.
AD  - d Centre for Reproductive Genetics Prof. Alberto Barros , Porto , Portugal.
FAU - Cheng, C Yan
AU  - Cheng CY
AD  - e The Mary M. Wohlford Laboratory for Male Contraceptive Research , Center for 
      Biomedical Research, Population Council , New York , NY , USA.
FAU - Alves, Marco G
AU  - Alves MG
AD  - a Laboratory of Cell Biology, Department of Microscopy and Unit for 
      Multidisciplinary Research in Biomedicine (UMIB), Institute of Biomedical 
      Sciences Abel Salazar (ICBAS), University of Porto , Porto , Portugal.
AD  - b CICS-UBI - Health Sciences Research Centre, University of Beira Interior , 
      Covilha , Portugal.
LA  - eng
GR  - R01 HD056034/HD/NICHD NIH HHS/United States
GR  - U54 HD029990/HD/NICHD NIH HHS/United States
PT  - Journal Article
PT  - Review
DEP - 20170126
PL  - England
TA  - Crit Rev Biochem Mol Biol
JT  - Critical reviews in biochemistry and molecular biology
JID - 8903774
RN  - EC 2.7.1.1 (MTOR protein, human)
RN  - EC 2.7.11.1 (TOR Serine-Threonine Kinases)
SB  - IM
MH  - Animals
MH  - Fertility/*physiology
MH  - Humans
MH  - Male
MH  - Signal Transduction/*physiology
MH  - Spermatogenesis/*physiology
MH  - TOR Serine-Threonine Kinases/*metabolism
MH  - Testis/*enzymology
PMC - PMC5499698
MID - NIHMS867145
OTO - NOTNLM
OT  - Sertoli cells
OT  - fertility
OT  - mTOR
OT  - male reproduction
OT  - spermatogenesis
COIS- Disclosure statement The authors report no conflicts of interest.
EDAT- 2017/01/27 06:00
MHDA- 2017/06/22 06:00
PMCR- 2018/06/01
CRDT- 2017/01/27 06:00
PHST- 2017/01/27 06:00 [pubmed]
PHST- 2017/06/22 06:00 [medline]
PHST- 2017/01/27 06:00 [entrez]
PHST- 2018/06/01 00:00 [pmc-release]
AID - 10.1080/10409238.2017.1279120 [doi]
PST - ppublish
SO  - Crit Rev Biochem Mol Biol. 2017 Jun;52(3):235-253. doi: 
      10.1080/10409238.2017.1279120. Epub 2017 Jan 26.