PMID- 28124649
OWN - NLM
STAT- MEDLINE
DCOM- 20170421
LR  - 20170421
IS  - 1945-8932 (Electronic)
IS  - 1945-8932 (Linking)
VI  - 30
IP  - 6
DP  - 2016 Nov 1
TI  - Dry eye disease and allergic conditions: A Korean nationwide population-based 
      study.
PG  - 397-401
LID - 10.2500/ajra.2016.30.4361 [doi]
AB  - BACKGROUND: Dry eye disease (DED) is a multifactorial disease of the tears and 
      ocular surface. No epidemiologic reports have yet been published about the 
      relationship between DED and allergic rhinitis or sensitization to allergens. 
      OBJECTIVE: To investigate the association between DED and allergic conditions in 
      the general adult Korean population. METHODS: This population-based 
      cross-sectional study included 17,542 individuals (ages >/= 19 years) who 
      participated in the Korea National Health and Nutrition Examination Survey 
      (KNHANES) from 2010 to 2012. Data for total serum immunoglobulin E (IgE) and 
      allergen-specific IgE levels were available for 1857 subjects. Data were analyzed 
      by using logistic regression to determine the association of DED with allergy or 
      allergic conditions, including allergic rhinitis, atopic dermatitis, asthma, 
      increased total serum IgE, and sensitization to house-dust mite (Dermatophagoides 
      farinae), dog, and cockroach allergens. RESULTS: The prevalence of DED, allergic 
      rhinitis, atopic dermatitis, and asthma was 10.4, 13.1, 2.2, and 3.3%, 
      respectively. The prevalence of the increased total serum IgE level and 
      sensitization to D. farinae, dog, and cockroach allergens was 34.6, 15.7, 1.0, 
      and 2.8%, respectively. After adjusting for general characteristics, DED was 
      significantly associated with allergic rhinitis (odds ratio 1.58 [95% confidence 
      interval, 1.38-1.81]) and D. farinae sensitization (odds ratio 1.80 [95% 
      confidence interval, 1.17-2.79]). CONCLUSION: This study demonstrated a close 
      association between DED and both allergic rhinitis and D. farinae sensitization 
      in Korean adults. Further studies are warranted to establish temporal 
      relationships between DED and allergic rhinitis.
FAU - Kim, Minkyeong
AU  - Kim M
AD  - Department of Family Medicine, Graduate School of Medicine, Ewha Womans 
      University, Seoul, South Korea.
FAU - Oh, Jong-Hyun
AU  - Oh JH
FAU - Park, Choul Yong
AU  - Park CY
FAU - Lee, Sang Wha
AU  - Lee SW
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Am J Rhinol Allergy
JT  - American journal of rhinology & allergy
JID - 101490775
RN  - 0 (Allergens)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Allergens/immunology
MH  - Animals
MH  - Asthma/*epidemiology
MH  - Cockroaches/immunology
MH  - Cross-Sectional Studies
MH  - Dermatitis, Atopic/*epidemiology
MH  - Dermatophagoides farinae/immunology
MH  - Dogs/immunology
MH  - Eye Diseases/*epidemiology
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - *Population Groups
MH  - Prevalence
MH  - Republic of Korea/epidemiology
MH  - Rhinitis, Allergic/*epidemiology
MH  - Young Adult
EDAT- 2017/01/27 06:00
MHDA- 2017/04/22 06:00
CRDT- 2017/01/27 06:00
PHST- 2017/01/27 06:00 [entrez]
PHST- 2017/01/27 06:00 [pubmed]
PHST- 2017/04/22 06:00 [medline]
AID - 10.2500/ajra.2016.30.4361 [doi]
PST - ppublish
SO  - Am J Rhinol Allergy. 2016 Nov 1;30(6):397-401. doi: 10.2500/ajra.2016.30.4361.