PMID- 28124751
OWN - NLM
STAT- MEDLINE
DCOM- 20180302
LR  - 20210109
IS  - 1573-7365 (Electronic)
IS  - 0885-7490 (Linking)
VI  - 32
IP  - 3
DP  - 2017 Jun
TI  - Peripheral and central administration of T3 improved the histological changes, 
      memory and the dentate gyrus electrophysiological activity in an animal model of 
      Alzheimer's disease.
PG  - 693-701
LID - 10.1007/s11011-016-9947-2 [doi]
AB  - The amyloid beta (Abeta) induced Alzheimer's disease (AD) is associated with 
      formation the amyloid plaques, cognitive impairments and decline in spontaneous 
      discharge of neurons. In the current study, we evaluated the effect of 
      subcutaneous (S. C) and intrahippocampal (I. H) administrations of 
      triiodothyronine (T3) on the histological changes, memory and the dentate gyrus 
      (DG) electrophysiological activity in an animal model of AD. Eighty adult male 
      Wistar rats (250-300 g) were divided randomly into five groups: Sham-Operated 
      (Sh-O), AD + Vehicle (S. C), AD + Vehicle (I. H), AD+ T3 (S. C) and AD + T3 (I. 
      H). In order to induce animal model of AD, Abeta (10 ng/mul, bilaterally) were 
      injected intrahippocampally. Rats were treated with T3 and/or normal saline for 
      10 days. Passive avoidance and spatial memory were evaluated in shuttle box 
      apparatus and Morris water maze, respectively. Neuronal single unit recording was 
      assessed from hippocampal DG. The percent of total time that animals spent in 
      target quarter, the mean latency time (sec), the step through latency and the 
      average number of spikes/bin were decreased significantly in AD rats compared 
      with the Sh-O group (p < 0.001) and were increased significantly in AD groups 
      that have received T3 (S. C and I. H) in compared with AD group (p < 0.01, 
      p < 0.001). Also, formation of amyloid plaques was decreased in AD rats treated 
      with T3.The results showed that T3 injection (S. C and I. H), by reduction of 
      neural damage and increment of neuronal spontaneous activity improved the memory 
      deficits in Abeta-induced AD rats.
FAU - Farbood, Yaghoob
AU  - Farbood Y
AD  - Physiology Research Center, Department of Physiology, Medical School, Ahvaz 
      Jundishapur University of Medical Sciences, Ahvaz, Iran. farbood_y@yahoo.com.
FAU - Shabani, Sahreh
AU  - Shabani S
AD  - Physiology Research Center, Department of Physiology, Medical School, Ahvaz 
      Jundishapur University of Medical Sciences, Ahvaz, Iran. sahreshabani1@gmail.com.
FAU - Sarkaki, Alireza
AU  - Sarkaki A
AD  - Physiology Research Center, Department of Physiology, Medical School, Ahvaz 
      Jundishapur University of Medical Sciences, Ahvaz, Iran.
FAU - Mard, Seyyed Ali
AU  - Mard SA
AD  - Physiology Research Center, Department of Physiology, Medical School, Ahvaz 
      Jundishapur University of Medical Sciences, Ahvaz, Iran.
FAU - Ahangarpour, Akram
AU  - Ahangarpour A
AD  - Physiology Research Center, Department of Physiology, Medical School, Ahvaz 
      Jundishapur University of Medical Sciences, Ahvaz, Iran.
FAU - Khorsandi, Layasadat
AU  - Khorsandi L
AD  - Cellular and Molecular Research Center, Department of Anatomical Sciences, 
      Medical School, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20170126
PL  - United States
TA  - Metab Brain Dis
JT  - Metabolic brain disease
JID - 8610370
RN  - 06LU7C9H1V (Triiodothyronine)
SB  - IM
MH  - Action Potentials/drug effects/physiology
MH  - Alzheimer Disease/drug therapy/*pathology/physiopathology
MH  - Animals
MH  - Dentate Gyrus/*drug effects/*pathology/physiology
MH  - *Disease Models, Animal
MH  - Injections, Intraventricular
MH  - Male
MH  - Microinjections/methods
MH  - Rats
MH  - Rats, Wistar
MH  - Spatial Memory/*drug effects/physiology
MH  - Triiodothyronine/*administration & dosage
OTO - NOTNLM
OT  - Alzheimer's disease
OT  - Memory
OT  - Single-unit recording
OT  - Triiodothyronine
EDAT- 2017/01/27 06:00
MHDA- 2018/03/03 06:00
CRDT- 2017/01/27 06:00
PHST- 2016/07/18 00:00 [received]
PHST- 2016/12/30 00:00 [accepted]
PHST- 2017/01/27 06:00 [pubmed]
PHST- 2018/03/03 06:00 [medline]
PHST- 2017/01/27 06:00 [entrez]
AID - 10.1007/s11011-016-9947-2 [pii]
AID - 10.1007/s11011-016-9947-2 [doi]
PST - ppublish
SO  - Metab Brain Dis. 2017 Jun;32(3):693-701. doi: 10.1007/s11011-016-9947-2. Epub 
      2017 Jan 26.