PMID- 28124760
OWN - NLM
STAT- MEDLINE
DCOM- 20170807
LR  - 20181113
IS  - 1434-9949 (Electronic)
IS  - 0770-3198 (Linking)
VI  - 36
IP  - 4
DP  - 2017 Apr
TI  - Neutrophil extracellular traps in neuropathy with anti-neutrophil cytoplasmic 
      autoantibody-associated microscopic polyangiitis.
PG  - 913-917
LID - 10.1007/s10067-017-3546-4 [doi]
AB  - To clarify the roles of neutrophils in anti-neutrophil cytoplasmic autoantibody 
      (ANCA)-associated vasculitic neuropathy, we studied neutrophil extracellular 
      traps (NETs) in peripheral nerve vasculitis. Stored nerve samples from 17 
      patients with microscopic polyangiitis (MPA) were immunohistochemically analyzed 
      using antibodies for citrullinated histone H3 (citH3) and various neutrophil 
      enzymes. We defined merged citH3 and extracellularly released myeloperoxidase 
      (MPO) as NET formation. We also compared NET formation between 
      MPO-ANCA-positive/negative MPA and rheumatoid arthritis (RA)-associated 
      vasculitic neuropathy. NETs were identified mostly in vasculitic small arterioles 
      of 6 of 12 MPO-ANCA-positive MPA patients, and their frequency was higher 
      (p < 0.05) than in ANCA-negative patients. NETs were not found in vasculitic 
      neuropathy with RA or patients with chronic inflammatory demyelinating 
      polyradiculoneuropathy. NETs were also observed in the peripheral nervous system 
      of MPA patients as well as in the lung and kidney. These results suggest that 
      NETs may be involved in the pathogenesis of MPA neuropathy.
FAU - Takeuchi, Hiroki
AU  - Takeuchi H
AD  - Department of Neurology, National Hospital Organization Minami-Kyoto National 
      Hospital, Joyo-shi, Kyoto, 610-0113, Japan. bambootakepv@gmail.com.
FAU - Kawasaki, Teruaki
AU  - Kawasaki T
AD  - Center of Neurological and Cerebrovascular Diseases, Takeda Hospital, Kyoto, 
      Japan.
FAU - Shigematsu, Kazuo
AU  - Shigematsu K
AD  - Department of Neurology, National Hospital Organization Minami-Kyoto National 
      Hospital, Joyo-shi, Kyoto, 610-0113, Japan.
FAU - Kawamura, Kazuyuki
AU  - Kawamura K
AD  - Department of Neurology, National Hospital Organization Minami-Kyoto National 
      Hospital, Joyo-shi, Kyoto, 610-0113, Japan.
FAU - Oka, Nobuyuki
AU  - Oka N
AD  - Department of Neurology, National Hospital Organization Minami-Kyoto National 
      Hospital, Joyo-shi, Kyoto, 610-0113, Japan.
LA  - eng
PT  - Comparative Study
PT  - Journal Article
DEP - 20170126
PL  - Germany
TA  - Clin Rheumatol
JT  - Clinical rheumatology
JID - 8211469
RN  - 0 (Antibodies, Antineutrophil Cytoplasmic)
RN  - EC 1.11.1.7 (Peroxidase)
SB  - IM
MH  - Aged
MH  - Anti-Neutrophil Cytoplasmic Antibody-Associated 
      Vasculitis/complications/*diagnosis
MH  - Antibodies, Antineutrophil Cytoplasmic/*blood
MH  - Arthritis, Rheumatoid/complications
MH  - Extracellular Traps/*immunology
MH  - Female
MH  - Humans
MH  - Japan
MH  - Kidney/pathology
MH  - Male
MH  - Microscopic Polyangiitis/*complications
MH  - Middle Aged
MH  - Neutrophils/immunology
MH  - Peripheral Nerves/physiopathology
MH  - Peripheral Nervous System Diseases/*diagnosis
MH  - Peroxidase/blood
MH  - Retrospective Studies
OTO - NOTNLM
OT  - MPO-ANCA
OT  - Microscopic polyangiitis
OT  - Neuropathy
OT  - Neutrophil extracellular traps
OT  - Peripheral nerve
EDAT- 2017/01/27 06:00
MHDA- 2017/08/08 06:00
CRDT- 2017/01/27 06:00
PHST- 2016/11/17 00:00 [received]
PHST- 2017/01/14 00:00 [accepted]
PHST- 2017/01/12 00:00 [revised]
PHST- 2017/01/27 06:00 [pubmed]
PHST- 2017/08/08 06:00 [medline]
PHST- 2017/01/27 06:00 [entrez]
AID - 10.1007/s10067-017-3546-4 [pii]
AID - 10.1007/s10067-017-3546-4 [doi]
PST - ppublish
SO  - Clin Rheumatol. 2017 Apr;36(4):913-917. doi: 10.1007/s10067-017-3546-4. Epub 2017 
      Jan 26.