PMID- 28125578
OWN - NLM
STAT- MEDLINE
DCOM- 20170808
LR  - 20181113
IS  - 1932-6203 (Electronic)
IS  - 1932-6203 (Linking)
VI  - 12
IP  - 1
DP  - 2017
TI  - Functional Connectivity Anomalies in Adolescents with Psychotic Symptoms.
PG  - e0169364
LID - 10.1371/journal.pone.0169364 [doi]
LID - e0169364
AB  - BACKGROUND: Previous magnetic resonance imaging (MRI) research suggests that, 
      prior to the onset of psychosis, high risk youths already exhibit brain 
      abnormalities similar to those present in patients with schizophrenia. 
      OBJECTIVES: The goal of the present study was to describe the functional 
      organization of endogenous activation in young adolescents who report auditory 
      verbal hallucinations (AVH) in view of the "distributed network" hypothesis of 
      psychosis. We recruited 20 young people aged 13-16 years who reported AVHs and 20 
      healthy controls matched for age, gender and handedness from local schools. 
      METHODS: Each participant underwent a semi-structured clinical interview and a 
      resting state (RS) neuroimaging protocol. We explored functional connectivity 
      (FC) involving three different networks: 1) default mode network (DMN) 2) 
      salience network (SN) and 3) central executive network (CEN). In line with 
      previous findings on the role of the auditory cortex in AVHs as reported by young 
      adolescents, we also investigated FC anomalies involving both the primary and 
      secondary auditory cortices (A1 and A2, respectively). Further, we explored 
      between-group inter-hemispheric FC differences (laterality) for both A1 and A2. 
      Compared to the healthy control group, the AVH group exhibited FC differences in 
      all three networks investigated. Moreover, FC anomalies were found in a neural 
      network including both A1 and A2. The laterality analysis revealed no 
      between-group, inter-hemispheric differences. CONCLUSIONS: The present study 
      suggests that young adolescents with subclinical psychotic symptoms exhibit 
      functional connectivity anomalies directly and indirectly involving the DMN, SN, 
      CEN and also a neural network including both primary and secondary auditory 
      cortical regions.
FAU - Amico, Francesco
AU  - Amico F
AUID- ORCID: 0000-0003-0837-2100
AD  - Department of Psychiatry, Royal College of Surgeons in Ireland, Dublin, Ireland.
FAU - O'Hanlon, Erik
AU  - O'Hanlon E
AD  - Department of Psychiatry, Royal College of Surgeons in Ireland, Dublin, Ireland.
AD  - Trinity College Institute of Neuroscience, Trinity College Dublin, Dublin, 
      Ireland.
FAU - Kraft, Dominik
AU  - Kraft D
AD  - Laboratory of Neuroimaging, Department of Psychiatry, Psychosomatic Medicine and 
      Psychotherapy, Goethe University, Frankfurt, Germany.
FAU - Oertel-Knochel, Viola
AU  - Oertel-Knochel V
AD  - Laboratory of Neuroimaging, Department of Psychiatry, Psychosomatic Medicine and 
      Psychotherapy, Goethe University, Frankfurt, Germany.
FAU - Clarke, Mary
AU  - Clarke M
AD  - Department of Psychiatry, Royal College of Surgeons in Ireland, Dublin, Ireland.
AD  - Department of Psychology, Division of Population Health Sciences, Royal College 
      of Surgeons in Ireland, Dublin, Ireland.
FAU - Kelleher, Ian
AU  - Kelleher I
AD  - Department of Psychiatry, Royal College of Surgeons in Ireland, Dublin, Ireland.
FAU - Higgins, Niamh
AU  - Higgins N
AD  - Department of Psychiatry, Royal College of Surgeons in Ireland, Dublin, Ireland.
FAU - Coughlan, Helen
AU  - Coughlan H
AD  - Department of Psychiatry, Royal College of Surgeons in Ireland, Dublin, Ireland.
FAU - Creegan, Daniel
AU  - Creegan D
AD  - Department of Psychiatry, Royal College of Surgeons in Ireland, Dublin, Ireland.
FAU - Heneghan, Mark
AU  - Heneghan M
AD  - Department of Psychiatry, Royal College of Surgeons in Ireland, Dublin, Ireland.
FAU - Power, Emmet
AU  - Power E
AD  - Department of Psychiatry, Royal College of Surgeons in Ireland, Dublin, Ireland.
FAU - Power, Lucy
AU  - Power L
AD  - Department of Psychiatry, Royal College of Surgeons in Ireland, Dublin, Ireland.
FAU - Ryan, Jessica
AU  - Ryan J
AD  - Department of Psychiatry, Royal College of Surgeons in Ireland, Dublin, Ireland.
FAU - Frodl, Thomas
AU  - Frodl T
AD  - Laboratory of Neuroimaging, Department of Psychiatry, Psychosomatic Medicine and 
      Psychotherapy, Goethe University, Frankfurt, Germany.
FAU - Cannon, Mary
AU  - Cannon M
AD  - Department of Psychiatry, Royal College of Surgeons in Ireland, Dublin, Ireland.
LA  - eng
PT  - Journal Article
DEP - 20170126
PL  - United States
TA  - PLoS One
JT  - PloS one
JID - 101285081
SB  - IM
MH  - Adolescent
MH  - Auditory Cortex/diagnostic imaging/pathology/*physiopathology
MH  - Brain Mapping
MH  - Case-Control Studies
MH  - Cerebrum/diagnostic imaging/pathology/*physiopathology
MH  - Child
MH  - Female
MH  - Hallucinations/diagnostic imaging/pathology/*physiopathology
MH  - Humans
MH  - Magnetic Resonance Imaging
MH  - Male
MH  - Nerve Net/diagnostic imaging/pathology/*physiopathology
MH  - Neural Pathways/diagnostic imaging/pathology/*physiopathology
MH  - Psychotic Disorders/diagnostic imaging/pathology/*physiopathology
PMC - PMC5268394
COIS- The authors have declared that no competing interests exist.
EDAT- 2017/01/27 06:00
MHDA- 2017/08/09 06:00
PMCR- 2017/01/26
CRDT- 2017/01/27 06:00
PHST- 2016/06/28 00:00 [received]
PHST- 2016/12/15 00:00 [accepted]
PHST- 2017/01/27 06:00 [entrez]
PHST- 2017/01/27 06:00 [pubmed]
PHST- 2017/08/09 06:00 [medline]
PHST- 2017/01/26 00:00 [pmc-release]
AID - PONE-D-16-23365 [pii]
AID - 10.1371/journal.pone.0169364 [doi]
PST - epublish
SO  - PLoS One. 2017 Jan 26;12(1):e0169364. doi: 10.1371/journal.pone.0169364. 
      eCollection 2017.