PMID- 28125929
OWN - NLM
STAT- MEDLINE
DCOM- 20180511
LR  - 20180511
IS  - 1563-5279 (Electronic)
IS  - 0020-7454 (Linking)
VI  - 127
IP  - 11
DP  - 2017 Nov
TI  - Trans-synaptic degeneration of motoneurons distal to chronic cervical spinal cord 
      compression in cervical spondylotic myelopathy.
PG  - 988-995
LID - 10.1080/00207454.2017.1287701 [doi]
AB  - OBJECTIVE: To assess the effect of chronic cervical spinal cord compression upon 
      remote motor unit function in patients with cervical spondylotic myelopathy 
      (CSM). METHODS: Fifty-three CSM patients and 47 healthy subjects were included. 
      Bilateral motor unit number estimations (MUNEs) were recorded from both abductor 
      digiti minimi and abductor pollicis brevis, and bilateral flexor carpi radialis 
      (FCR) H-reflexes were examined in all subjects along with the nine-hole peg test 
      (NHPT). The main outcome measures included the number of motor units, the average 
      single motor unit potential (SMUP) area, the FCR Hmax/Mmax ratios and the NHPT 
      time. RESULTS: Statistically significant results compared to healthy controls 
      included increased average SMUP area, increased FCR Hmax/Mmax ratio and increased 
      NHPT time (p < 0.05). Abnormal SMUP was observed in 10/53 (18.9%) CSM patients 
      along with reduced motor units in 3 of these 10 patients, while the FCR Hmax/Mmax 
      ratios in the CSM patients with abnormal MUNE were higher than those in others (p 
      < 0.05). There was a positive correlation between the NHPT time and the average 
      SMUP area, and a negative correlation was noted between the NHPT time and the 
      number of motor units (p < 0.05). CONCLUSION: In CSM patients, the motor units 
      below the level of compression may exhibit dysfunction, which is likely a result 
      of trans-synaptic degeneration. Both cervical spinal cord compressive injury and 
      this trans-synaptic degeneration contribute to the impairment of fine motor 
      ability in CSM patients. Therefore, treatment and rehabilitation efforts should 
      account for these two dysfunctions.
FAU - Zheng, Chaojun
AU  - Zheng C
AUID- ORCID: 0000-0002-1165-2528
AD  - a Department of Orthopedics, Huashan Hospital , Fudan University , Shanghai , 
      China.
FAU - Zhu, Yu
AU  - Zhu Y
AUID- ORCID: 0000-0003-2770-2371
AD  - b Department of Physical Medicine and Rehabilitation , Upstate Medical 
      University, State University of New York at Syracuse , Syracuse , NY , USA.
FAU - Lu, Feizhou
AU  - Lu F
AUID- ORCID: 0000-0002-7199-7982
AD  - a Department of Orthopedics, Huashan Hospital , Fudan University , Shanghai , 
      China.
AD  - c Department of Orthopedics, The Fifth People's Hospital , Fudan University, 
      Shanghai , China.
FAU - Ma, Xiaosheng
AU  - Ma X
AUID- ORCID: 0000-0003-2979-0870
AD  - a Department of Orthopedics, Huashan Hospital , Fudan University , Shanghai , 
      China.
FAU - Tian, Dong
AU  - Tian D
AUID- ORCID: 0000-0003-3388-0334
AD  - d Department of Hand Surgery, Huashan Hospital , Fudan University, Shanghai , 
      China.
FAU - Jiang, Jianyuan
AU  - Jiang J
AUID- ORCID: 0000-0001-6876-7820
AD  - a Department of Orthopedics, Huashan Hospital , Fudan University , Shanghai , 
      China.
LA  - eng
PT  - Journal Article
DEP - 20170213
PL  - England
TA  - Int J Neurosci
JT  - The International journal of neuroscience
JID - 0270707
SB  - IM
MH  - Adult
MH  - Aged
MH  - Cervical Cord/*pathology
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Motor Neurons/*pathology
MH  - Muscle, Skeletal/*innervation
MH  - Recruitment, Neurophysiological
MH  - Retrograde Degeneration/etiology/*pathology/physiopathology
MH  - Spinal Cord Compression/*complications/etiology
MH  - Spondylosis/*complications
OTO - NOTNLM
OT  - Trans-synaptic degeneration
OT  - cervical spondylotic myelopathy
OT  - motor unit number estimation
EDAT- 2017/01/28 06:00
MHDA- 2018/05/12 06:00
CRDT- 2017/01/28 06:00
PHST- 2017/01/28 06:00 [pubmed]
PHST- 2018/05/12 06:00 [medline]
PHST- 2017/01/28 06:00 [entrez]
AID - 10.1080/00207454.2017.1287701 [doi]
PST - ppublish
SO  - Int J Neurosci. 2017 Nov;127(11):988-995. doi: 10.1080/00207454.2017.1287701. 
      Epub 2017 Feb 13.