PMID- 28126500
OWN - NLM
STAT- MEDLINE
DCOM- 20180829
LR  - 20190329
IS  - 1090-2139 (Electronic)
IS  - 0889-1591 (Print)
IS  - 0889-1591 (Linking)
VI  - 62
DP  - 2017 May
TI  - Systemic inflammation and resting state connectivity of the default mode network.
PG  - 162-170
LID - S0889-1591(17)30014-4 [pii]
LID - 10.1016/j.bbi.2017.01.013 [doi]
AB  - The default mode network (DMN) encompasses brain systems that exhibit coherent 
      neural activity at rest. DMN brain systems have been implicated in diverse 
      social, cognitive, and affective processes, as well as risk for forms of dementia 
      and psychiatric disorders that associate with systemic inflammation. Areas of the 
      anterior cingulate cortex (ACC) and surrounding medial prefrontal cortex (mPFC) 
      within the DMN have been implicated specifically in regulating autonomic and 
      neuroendocrine processes that relate to systemic inflammation via bidirectional 
      signaling mechanisms. However, it is still unclear whether indicators of 
      inflammation relate directly to coherent resting state activity of the ACC, mPFC, 
      or other areas within the DMN. Accordingly, we tested whether plasma interleukin 
      (IL)-6, an indicator of systemic inflammation, covaried with resting-state 
      functional connectivity of the DMN among 98 adults aged 30-54 (39% male; 81% 
      Caucasian). Independent component analyses were applied to resting state fMRI 
      data to generate DMN connectivity maps. Voxel-wise regression analyses were then 
      used to test for associations between IL-6 and DMN connectivity across 
      individuals, controlling for age, sex, body mass index, and fMRI signal motion. 
      Within the DMN, IL-6 covaried positively with connectivity of the sub-genual ACC 
      and negatively with a region of the dorsal medial PFC at corrected statistical 
      thresholds. These novel findings offer evidence for a unique association between 
      a marker of systemic inflammation (IL-6) and ACC and mPFC functional connectivity 
      within the DMN, a network that may be important for linking aspects of immune 
      function to psychological and behavioral states in health and disease.
CI  - Copyright (c) 2017 Elsevier Inc. All rights reserved.
FAU - Marsland, Anna L
AU  - Marsland AL
AD  - Department of Psychology, University of Pittsburgh, Pittsburgh, PA 15260, United 
      States. Electronic address: marsland@pitt.edu.
FAU - Kuan, Dora C-H
AU  - Kuan DC
AD  - Department of Psychology, University of Pittsburgh, Pittsburgh, PA 15260, United 
      States.
FAU - Sheu, Lei K
AU  - Sheu LK
AD  - Department of Psychology, University of Pittsburgh, Pittsburgh, PA 15260, United 
      States.
FAU - Krajina, Katarina
AU  - Krajina K
AD  - Department of Psychology, University of Pittsburgh, Pittsburgh, PA 15260, United 
      States.
FAU - Kraynak, Thomas E
AU  - Kraynak TE
AD  - Department of Psychology, University of Pittsburgh, Pittsburgh, PA 15260, United 
      States; Center for the Neural Basis of Cognition, University of Pittsburgh and 
      Carnegie Mellon University, Pittsburgh, PA 15213, United States.
FAU - Manuck, Stephen B
AU  - Manuck SB
AD  - Department of Psychology, University of Pittsburgh, Pittsburgh, PA 15260, United 
      States.
FAU - Gianaros, Peter J
AU  - Gianaros PJ
AD  - Department of Psychology, University of Pittsburgh, Pittsburgh, PA 15260, United 
      States; Center for the Neural Basis of Cognition, University of Pittsburgh and 
      Carnegie Mellon University, Pittsburgh, PA 15213, United States.
LA  - eng
GR  - P01 HL040962/HL/NHLBI NIH HHS/United States
GR  - R01 HL089850/HL/NHLBI NIH HHS/United States
GR  - T32 HL007560/HL/NHLBI NIH HHS/United States
PT  - Journal Article
DEP - 20170123
PL  - Netherlands
TA  - Brain Behav Immun
JT  - Brain, behavior, and immunity
JID - 8800478
RN  - 0 (Interleukin-6)
RN  - 9007-41-4 (C-Reactive Protein)
SB  - IM
MH  - Adult
MH  - Brain/*diagnostic imaging/physiopathology
MH  - Brain Mapping
MH  - C-Reactive Protein/metabolism
MH  - Female
MH  - Humans
MH  - Inflammation/blood/*diagnostic imaging/physiopathology
MH  - Interleukin-6/blood
MH  - Magnetic Resonance Imaging
MH  - Male
MH  - Middle Aged
MH  - Nerve Net/*diagnostic imaging/physiopathology
PMC - PMC5402695
MID - NIHMS851897
OTO - NOTNLM
OT  - Anterior cingulate cortex
OT  - CRP
OT  - Default mode network
OT  - IL-6
OT  - Inflammation
OT  - Prefrontal cortex
OT  - Resting state connectivity
COIS- Conflict of interest statement: The authors declare no conflict of interest.
EDAT- 2017/01/28 06:00
MHDA- 2018/08/30 06:00
PMCR- 2018/05/01
CRDT- 2017/01/28 06:00
PHST- 2016/06/29 00:00 [received]
PHST- 2017/01/20 00:00 [revised]
PHST- 2017/01/21 00:00 [accepted]
PHST- 2017/01/28 06:00 [pubmed]
PHST- 2018/08/30 06:00 [medline]
PHST- 2017/01/28 06:00 [entrez]
PHST- 2018/05/01 00:00 [pmc-release]
AID - S0889-1591(17)30014-4 [pii]
AID - 10.1016/j.bbi.2017.01.013 [doi]
PST - ppublish
SO  - Brain Behav Immun. 2017 May;62:162-170. doi: 10.1016/j.bbi.2017.01.013. Epub 2017 
      Jan 23.