PMID- 28127896
OWN - NLM
STAT- MEDLINE
DCOM- 20180606
LR  - 20231213
IS  - 2059-2310 (Electronic)
IS  - 2059-2302 (Linking)
VI  - 89
IP  - 3
DP  - 2017 Mar
TI  - New insights in HLA-E polymorphism by refined analysis of the full-length gene.
PG  - 143-149
LID - 10.1111/tan.12965 [doi]
AB  - BACKGROUND: Human leukocyte antigen (HLA)-E is a non-classical HLA class I 
      molecule that plays a role in both the innate and the adaptive immune response 
      through interaction with receptors on natural killer- and T-cells. The HLA-E gene 
      is characterized by limited polymorphism compared with the classical HLA loci on 
      chromosome 6. At the start of this study, only 13 variable sites had been 
      identified (IPD-IMGT/HLA Database v3.18.0). While most previous studies focused 
      on polymorphism in exons 2 and 3 or specific gene regions, polymorphism in the 
      other exons and introns could influence protein expression and function as well. 
      Studies that investigate extended HLA-E polymorphism are therefore needed to 
      better understand the functional relevance of HLA-E in health and disease. AIMS: 
      The aim of this study was to examine the variability of the full-length HLA-E 
      gene region in individuals originating from different populations. MATERIALS AND 
      METHODS/RESULTS: A total of 7 new HLA-E alleles were identified using full-length 
      HLA-E sequencing of 123 individuals from Asian, Dutch or Hunan Han origin. 
      Furthermore, genome variation analysis of the third phase of the 1000 genomes 
      database showed 107 new variable sites in 2504 individuals originating from 26 
      different populations. DISCUSSION AND CONCLUSION: Our study demonstrates that the 
      nucleotide variability of the HLA-E gene is much higher than previously known, 
      albeit in only a limited number of individuals. Overall only 2 variants, 
      HLA-E*01:01 and *01:03, are frequently present worldwide, suggesting that 
      balancing selection is acting on HLA-E.
CI  - (c) 2017 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.
FAU - Olieslagers, T I
AU  - Olieslagers TI
AD  - Transplantation Immunology, Tissue Typing Laboratory, Maastricht University 
      Medical Center, Maastricht, the Netherlands.
FAU - Voorter, C E M
AU  - Voorter CE
AD  - Transplantation Immunology, Tissue Typing Laboratory, Maastricht University 
      Medical Center, Maastricht, the Netherlands.
FAU - Groeneweg, M
AU  - Groeneweg M
AD  - Transplantation Immunology, Tissue Typing Laboratory, Maastricht University 
      Medical Center, Maastricht, the Netherlands.
FAU - Xu, Y
AU  - Xu Y
AUID- ORCID: 0000-0002-4546-2191
AD  - Immunogenetics Laboratory, Shenzhen Blood Center, Shenzhen, China.
FAU - Wieten, L
AU  - Wieten L
AD  - Transplantation Immunology, Tissue Typing Laboratory, Maastricht University 
      Medical Center, Maastricht, the Netherlands.
FAU - Tilanus, M G J
AU  - Tilanus MG
AD  - Transplantation Immunology, Tissue Typing Laboratory, Maastricht University 
      Medical Center, Maastricht, the Netherlands.
LA  - eng
PT  - Journal Article
DEP - 20170127
PL  - England
TA  - HLA
JT  - HLA
JID - 101675570
RN  - 0 (Histocompatibility Antigens Class I)
RN  - 0 (Protein Isoforms)
SB  - IM
MH  - Adaptive Immunity
MH  - *Alleles
MH  - Asian People
MH  - B-Lymphocytes/cytology/immunology
MH  - Exons
MH  - Gene Expression
MH  - *Haplotypes
MH  - High-Throughput Nucleotide Sequencing
MH  - Histocompatibility Antigens Class I/*genetics/immunology
MH  - Histocompatibility Testing
MH  - Human Genome Project
MH  - Humans
MH  - Immunity, Innate
MH  - Introns
MH  - Killer Cells, Natural/cytology/immunology
MH  - *Polymorphism, Genetic
MH  - Protein Isoforms/genetics/immunology
MH  - T-Lymphocytes/cytology/immunology
MH  - White People
MH  - HLA-E Antigens
OTO - NOTNLM
OT  - HLA-E
OT  - 1000 genomes analysis
OT  - full-length gene polymorphism
OT  - human leukocyte antigens
OT  - sequence-based typing
OT  - single nucleotide polymorphism
EDAT- 2017/01/28 06:00
MHDA- 2018/06/07 06:00
CRDT- 2017/01/28 06:00
PHST- 2016/07/07 00:00 [received]
PHST- 2016/12/02 00:00 [revised]
PHST- 2017/01/05 00:00 [accepted]
PHST- 2017/01/28 06:00 [pubmed]
PHST- 2018/06/07 06:00 [medline]
PHST- 2017/01/28 06:00 [entrez]
AID - 10.1111/tan.12965 [doi]
PST - ppublish
SO  - HLA. 2017 Mar;89(3):143-149. doi: 10.1111/tan.12965. Epub 2017 Jan 27.